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01-01-2011 | Original Article—Alimentary Tract

Evaluation of new subclassification of type V_I pit pattern for determining the depth and type of invasion of colorectal neoplasm

Authors: Kenshi Matsumoto, Akihito Nagahara, Takeshi Terai, Hiroya Ueyama, Hideaki Ritsuno, Hiroki Mori, Kohsaburo Nakae, Kazuko Beppu, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Tatsuo Ogihara, Takashi Yao, Sumio Watanabe

Published in: Journal of Gastroenterology | Issue 1/2011

Abstract

Background

Colorectal neoplasms with a type V_I pit pattern include various lesions, such as adenomas, intramucosal cancers, and submucosal carcinomas.

Methods

We analyzed 96 colorectal neoplasms with a type V_I pit pattern and identified six different variants: (1) unclear outline of the pit; (2) irregular margins of the pit; (3) narrowing of the pit; (4) ragged array of the pit; (5) high residual density of the pit; (6) abnormal branching of the pit. We examined the relationship between the appearance of each V_I pit pattern and histology, including the depth of invasion.

Results

In univariate logistic regression analysis the unclear outline, irregular margins, and narrowing of the pit were significantly associated with a submucosal (SM) invasion ≥1000 μm (P < 0.01). In multivariate logistic regression analysis, unclear outline of the pit was shown to be the only significant predictor of highly invasive submucosal cancer (odds ratio = 24.20, P < 0.0001). Regarding tumor morphology, the following were significantly associated with an SM invasion ≥1000 μm: in protruded type, ragged array (P = 0.022), irregular margins of the pit (P = 0.011), and unclear outline of the pit (P < 0.01); in flat type, irregular margins of the pit (P < 0.01) and unclear outline of the pit (P < 0.01); and in the depressed type, narrowing of the pit (P = 0.015) and unclear outline of the pit (P < 0.01).

Conclusions

Subclassification of the type V_I pit pattern is useful for determining the depth of invasion of colorectal neoplasms.

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Title: Evaluation of new subclassification of type VI pit pattern for determining the depth and type of invasion of colorectal neoplasm
Authors: Kenshi Matsumoto
Akihito Nagahara
Takeshi Terai
Hiroya Ueyama
Hideaki Ritsuno
Hiroki Mori
Kohsaburo Nakae
Kazuko Beppu
Tomoyoshi Shibuya
Naoto Sakamoto
Taro Osada
Tatsuo Ogihara
Takashi Yao
Sumio Watanabe
Publication date: 01-01-2011
Publisher: Springer Japan
Published in: Journal of Gastroenterology / Issue 1/2011
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI: https://doi.org/10.1007/s00535-010-0300-y

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Evaluation of new subclassification of type V_I pit pattern for determining the depth and type of invasion of colorectal neoplasm

Abstract

Background

Methods

Results

Conclusions

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Abstract

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Conclusions

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