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Published in: Journal of Hepato-Biliary-Pancreatic Sciences 2/2011

01-03-2011 | Original article

Donor quality of life after living donor liver transplantation: a prospective study

Authors: Junichi Togashi, Yasuhiko Sugawara, Sumihito Tamura, Noriyo Yamashiki, Junichi Kaneko, Taku Aoki, Kiyoshi Hasegawa, Yoshifumi Beck, Masatoshi Makuuchi, Norihiro Kokudo

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 2/2011

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Abstract

Background/purpose

It is important to determine the health-related quality of life of live donors in liver transplantation.

Materials and methods

We reviewed 35 live liver donors and prospectively and longitudinally evaluated their health-related quality for 1.5 years post-surgery based on the Short Form-36 version 2 questionnaire. Scores of the donors stratified by the clinical data were analyzed. The study was approved by the University of Tokyo Institutional Review Board (No. 1533).

Results

There was no donor mortality in the donor population studied. The percentage of major complications greater than Clavien’s classification grade III was 8.6%. The physical component summary score decreased to 42.9 (p < 0.01) at 3 months, but recovered within 6 months after the operation. The mental component summary scores did not change during the observation period. The stratification study revealed that age and postoperative complications remained significant factors among the high physical component summary scores 3 months after the operation.

Conclusions

The findings from this survey suggest that liver harvesting does not decrease the donor’s quality of life during the 1.5 years following the surgery.
Literature
1.
go back to reference Miyagi S, Kawagishi N, Fujimori K, Sekiguchi S, Fukumori T, Akamatsu Y, et al. Risks of donation and quality of donors’ life after living donor liver transplantation. Transpl Int. 2005;18:47–51.PubMedCrossRef Miyagi S, Kawagishi N, Fujimori K, Sekiguchi S, Fukumori T, Akamatsu Y, et al. Risks of donation and quality of donors’ life after living donor liver transplantation. Transpl Int. 2005;18:47–51.PubMedCrossRef
2.
go back to reference The Japanese Liver Transplantation Society. Liver transplantation in Japan-Registry by the Japanese Liver Transplantation Society (in Japanese with English abstract). Isyoku. 2006;41:599–606. The Japanese Liver Transplantation Society. Liver transplantation in Japan-Registry by the Japanese Liver Transplantation Society (in Japanese with English abstract). Isyoku. 2006;41:599–606.
3.
go back to reference Akabayashi A, Slingsby BT, Fujita M. The first donor death after living-related liver transplantation in Japan. Transplantation. 2004;77:634.PubMedCrossRef Akabayashi A, Slingsby BT, Fujita M. The first donor death after living-related liver transplantation in Japan. Transplantation. 2004;77:634.PubMedCrossRef
4.
go back to reference Umeshita K, Fujiwara K, Kiyosawa K, Makuuchi M, Satomi S, Sugimachi K, et al. Japanese Liver Transplantation Society. Operative morbidity of living liver donors in Japan. Lancet. 2003;362:687–90.PubMedCrossRef Umeshita K, Fujiwara K, Kiyosawa K, Makuuchi M, Satomi S, Sugimachi K, et al. Japanese Liver Transplantation Society. Operative morbidity of living liver donors in Japan. Lancet. 2003;362:687–90.PubMedCrossRef
5.
go back to reference Anonymous. Adult-to-adult living donor liver transplantation cohort study (A2ALL). Hepatology 2003;38:792. Anonymous. Adult-to-adult living donor liver transplantation cohort study (A2ALL). Hepatology 2003;38:792.
6.
go back to reference Tamura S, Sugawara Y, Kokudo N. Donor evaluation and hepatectomy for living-donor liver transplantation. J Hepatobiliary Pancreat Surg. 2008;15:79–91.PubMedCrossRef Tamura S, Sugawara Y, Kokudo N. Donor evaluation and hepatectomy for living-donor liver transplantation. J Hepatobiliary Pancreat Surg. 2008;15:79–91.PubMedCrossRef
7.
go back to reference Hadjianastassiou VG, Johnson RJ, Rudge CJ, Mamode N. 2509 living donor nephrectomies, morbidity and mortality, including the UK introduction of laparoscopic donor surgery. Am J Transplant. 2007;7:2532–7.PubMedCrossRef Hadjianastassiou VG, Johnson RJ, Rudge CJ, Mamode N. 2509 living donor nephrectomies, morbidity and mortality, including the UK introduction of laparoscopic donor surgery. Am J Transplant. 2007;7:2532–7.PubMedCrossRef
8.
go back to reference Schnitzbauer AA, Hornung M, Seidel U, Kruger B, Kramer BK, Schlitt HJ, et al. Does mini-incision donor nephrectomy improve quality of life in living kidney donors? Clin Transplant. 2007;21:235–40.PubMedCrossRef Schnitzbauer AA, Hornung M, Seidel U, Kruger B, Kramer BK, Schlitt HJ, et al. Does mini-incision donor nephrectomy improve quality of life in living kidney donors? Clin Transplant. 2007;21:235–40.PubMedCrossRef
9.
go back to reference Aguiar WF, Passerotti CC, Claro JF, Almeida CJ, Gattas N, Cedenho AP, et al. Mini-incisions by lobotomy or subcostal access in living kidney donors: a randomized trial comparing pain, safety, and quality of life. Clin Transpl. 2007;21:269–76.CrossRef Aguiar WF, Passerotti CC, Claro JF, Almeida CJ, Gattas N, Cedenho AP, et al. Mini-incisions by lobotomy or subcostal access in living kidney donors: a randomized trial comparing pain, safety, and quality of life. Clin Transpl. 2007;21:269–76.CrossRef
10.
go back to reference Kok NF, Alwayn IP, Tran KT, Hop WC, Weimar W, Ijzermans JN. Psychosocial and physical impairment after mini-incision open and laparoscopic donor nephrectomy: a prospective study. Transplantation. 2006;82:1291–7.PubMedCrossRef Kok NF, Alwayn IP, Tran KT, Hop WC, Weimar W, Ijzermans JN. Psychosocial and physical impairment after mini-incision open and laparoscopic donor nephrectomy: a prospective study. Transplantation. 2006;82:1291–7.PubMedCrossRef
11.
go back to reference Reimer J, Rensing A, Haasen C, Philipp T, Pietruck F, Franke GH. The impact of living-related kidney transplantation on the donor’s life. Transplantation. 2006;81:1268–73.PubMedCrossRef Reimer J, Rensing A, Haasen C, Philipp T, Pietruck F, Franke GH. The impact of living-related kidney transplantation on the donor’s life. Transplantation. 2006;81:1268–73.PubMedCrossRef
12.
go back to reference Satou S, Sugawara Y, Tamura S, Kishi Y, Kaneko J, Matsui Y, et al. Three-dimensional computed tomography for planning donor hepatectomy. Transplant Proc. 2007;39:145–9.PubMedCrossRef Satou S, Sugawara Y, Tamura S, Kishi Y, Kaneko J, Matsui Y, et al. Three-dimensional computed tomography for planning donor hepatectomy. Transplant Proc. 2007;39:145–9.PubMedCrossRef
13.
go back to reference Urata K, Kawasaki S, Matsunami H, Hashikura Y, Ikegami T, Ishizone S, et al. Calculation of child and adult standard liver volume for liver transplantation. Hepatology. 1995;21:1317–21.PubMedCrossRef Urata K, Kawasaki S, Matsunami H, Hashikura Y, Ikegami T, Ishizone S, et al. Calculation of child and adult standard liver volume for liver transplantation. Hepatology. 1995;21:1317–21.PubMedCrossRef
14.
go back to reference Sugawara Y, Makuuchi M. Technical advances in living-related liver transplantation. J Hepatobiliary Pancreat Surg. 1999;6:245–53.PubMedCrossRef Sugawara Y, Makuuchi M. Technical advances in living-related liver transplantation. J Hepatobiliary Pancreat Surg. 1999;6:245–53.PubMedCrossRef
15.
go back to reference Kokudo N, Sugawara Y, Imamura H, Sano K, Makuuchi M. Sling suspension of the liver in donor operation: a gradual tape-repositioning technique. Transplantation. 2003;76:803–7.PubMedCrossRef Kokudo N, Sugawara Y, Imamura H, Sano K, Makuuchi M. Sling suspension of the liver in donor operation: a gradual tape-repositioning technique. Transplantation. 2003;76:803–7.PubMedCrossRef
16.
go back to reference Kokudo N, Imamura H, Sano K, Zhang K, Hasegawa K, Sugawara Y, et al. Ultrasonically assisted retrohepatic dissection for a liver hanging maneuver. Ann Surg. 2005;242:651–4.PubMedCrossRef Kokudo N, Imamura H, Sano K, Zhang K, Hasegawa K, Sugawara Y, et al. Ultrasonically assisted retrohepatic dissection for a liver hanging maneuver. Ann Surg. 2005;242:651–4.PubMedCrossRef
17.
go back to reference Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.PubMedCrossRef Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–13.PubMedCrossRef
18.
go back to reference Karliova M, Malagó M, Valentin-Gamazo C, Reimer J, Treichel U, Franke GH, et al. Living-related liver transplantation from the view of the donor: a 1-year follow-up survey. Transplantation. 2002;73:1799–804.PubMedCrossRef Karliova M, Malagó M, Valentin-Gamazo C, Reimer J, Treichel U, Franke GH, et al. Living-related liver transplantation from the view of the donor: a 1-year follow-up survey. Transplantation. 2002;73:1799–804.PubMedCrossRef
19.
go back to reference Chan SC, Liu CL, Lo CM, Lam BK, Lee EW, Fan ST. Donor quality of life before and after adult-to-adult right liver live donor liver transplantation. Liver Transpl. 2006;12:1529–36.PubMedCrossRef Chan SC, Liu CL, Lo CM, Lam BK, Lee EW, Fan ST. Donor quality of life before and after adult-to-adult right liver live donor liver transplantation. Liver Transpl. 2006;12:1529–36.PubMedCrossRef
20.
go back to reference Verbesey JE, Simpson MA, Pomposelli JJ, Richman E, Bracken AM, Garrigan K, et al. Living donor adult liver transplantation: a longitudinal study of the donor’s quality of life. Am J Transplant. 2005;5:2770–7.PubMedCrossRef Verbesey JE, Simpson MA, Pomposelli JJ, Richman E, Bracken AM, Garrigan K, et al. Living donor adult liver transplantation: a longitudinal study of the donor’s quality of life. Am J Transplant. 2005;5:2770–7.PubMedCrossRef
21.
go back to reference Humar A, Carolan E, Ibrahim H, Horn K, Larson E, Glessing B, et al. A comparison of surgical outcomes and quality of life surveys in right lobe vs. left lateral segment liver donors. Am J Transplant. 2005;5:805–9.PubMedCrossRef Humar A, Carolan E, Ibrahim H, Horn K, Larson E, Glessing B, et al. A comparison of surgical outcomes and quality of life surveys in right lobe vs. left lateral segment liver donors. Am J Transplant. 2005;5:805–9.PubMedCrossRef
22.
go back to reference Suh KS, Yi NJ, Kim T, Kim J, Shin WY, Lee HW, et al. Laparoscopy-assisted donor right hepatectomy using a hand port system preserving the middle hepatic vein branches. World J Surg. 2009;33:526–33.PubMedCrossRef Suh KS, Yi NJ, Kim T, Kim J, Shin WY, Lee HW, et al. Laparoscopy-assisted donor right hepatectomy using a hand port system preserving the middle hepatic vein branches. World J Surg. 2009;33:526–33.PubMedCrossRef
23.
go back to reference Kim SH, Cho SY, Lee KW, Park SJ, Han SS. Upper midline incision for living donor right hepatectomy. Liver Transpl. 2009;15:193–8.PubMedCrossRef Kim SH, Cho SY, Lee KW, Park SJ, Han SS. Upper midline incision for living donor right hepatectomy. Liver Transpl. 2009;15:193–8.PubMedCrossRef
Metadata
Title
Donor quality of life after living donor liver transplantation: a prospective study
Authors
Junichi Togashi
Yasuhiko Sugawara
Sumihito Tamura
Noriyo Yamashiki
Junichi Kaneko
Taku Aoki
Kiyoshi Hasegawa
Yoshifumi Beck
Masatoshi Makuuchi
Norihiro Kokudo
Publication date
01-03-2011
Publisher
Springer Japan
Published in
Journal of Hepato-Biliary-Pancreatic Sciences / Issue 2/2011
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI
https://doi.org/10.1007/s00534-010-0340-y

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