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Published in: Journal of Hepato-Biliary-Pancreatic Sciences 5/2009

01-09-2009 | Original article

A pancreaticoduodenectomy is acceptable for periampullary tumors in the elderly, even in patients over 80 years of age

Authors: Masaji Tani, Manabu Kawai, Seiko Hirono, Shinomi Ina, Motoki Miyazawa, Ryohei Nishioka, Atsushi Shimizu, Kazuhisa Uchiyama, Hiroki Yamaue

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 5/2009

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Abstract

Background

Although the mortality rates for pancreaticoduodenectomy have been reported to be low for periampullary tumors at high-volume centers, postoperative results still remain unclear for elderly patients over 80 years of age.

Methods

This was a retrospective study of patients who underwent a pancreaticoduodenectomy and consisted of 335 patients who were treated for periampullary tumors between January 1994 and August 2008. The main outcomes were postoperative complications, mortality, and the length of hospital stay among the elderly patients, and they were analyzed in three groups: elderly patients over 80 years old, septuagenarians, and those under 70 years of age.

Results

The performance status of elderly patients was lower than that of the patients under 70 (P < 0.05), and the elderly had a higher American Society of Anesthesiologists physical status classification score (P < 0.001) as well as low hemoglobin and serum albumin levels (P < 0.01 and P < 0.001, respectively). The incidence of delayed gastric emptying in the elderly was higher; however, there was no significant difference. The other outcomes in the elderly group were similar to those of the other groups.

Conclusions

Pancreaticoduodenectomy was considered to be a feasible surgical procedure for elderly patients who had a good performance status.
Literature
1.
go back to reference Kincannon CL. National bibliography of US government publications. Statistial Abstract of the United States: 2004–2005. Washington: US Census Bureau; 2005. Kincannon CL. National bibliography of US government publications. Statistial Abstract of the United States: 2004–2005. Washington: US Census Bureau; 2005.
2.
go back to reference Ishikawa A, Beppu M, Sato R. Population statistics of Japan 2006. Yamato-sogo. Tokyo, Japan; 2006. Ishikawa A, Beppu M, Sato R. Population statistics of Japan 2006. Yamato-sogo. Tokyo, Japan; 2006.
3.
go back to reference Etzioni D, Liu J, Maggard M, Ko CY. The aging population and its impact on the surgery workforce. Ann Surg. 2003;238:170–7.PubMed Etzioni D, Liu J, Maggard M, Ko CY. The aging population and its impact on the surgery workforce. Ann Surg. 2003;238:170–7.PubMed
4.
go back to reference Lillemoe KD. Pancreatic and periampullary carcinoma in the elderly. Gastrointestinal surgery in the elderly. Probl Gen Surg. 1996;13:108–20. Lillemoe KD. Pancreatic and periampullary carcinoma in the elderly. Gastrointestinal surgery in the elderly. Probl Gen Surg. 1996;13:108–20.
5.
go back to reference Yeo CJ, Cameron JL, Sohn TA, Lillemoe KD, Pitt HA, Talamini MA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg. 1997;226:248–57.PubMedCrossRef Yeo CJ, Cameron JL, Sohn TA, Lillemoe KD, Pitt HA, Talamini MA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg. 1997;226:248–57.PubMedCrossRef
6.
go back to reference Suojaranta-Ylinen RT, Kuitunen AH, Kukkonen SI. Risk evaluation of cardiac surgery in octogenarians. J Cardiothorac Vasc Anesth. 2006;20:526–30.PubMedCrossRef Suojaranta-Ylinen RT, Kuitunen AH, Kukkonen SI. Risk evaluation of cardiac surgery in octogenarians. J Cardiothorac Vasc Anesth. 2006;20:526–30.PubMedCrossRef
7.
go back to reference Vickers SM, Kerby JD, Smoot TM, Shumate CR, Halpern NB, Aldrete JS, et al. Economics of pancreaticoduodenectomy in the elerly. Surgery. 1996;120:620–6.PubMedCrossRef Vickers SM, Kerby JD, Smoot TM, Shumate CR, Halpern NB, Aldrete JS, et al. Economics of pancreaticoduodenectomy in the elerly. Surgery. 1996;120:620–6.PubMedCrossRef
8.
go back to reference Dicarlo V, Balzano G, Zebri A, Villa E. Pancreatic cancer resection in elderly patients. Br J Surg. 1998;85:607–10.PubMedCrossRef Dicarlo V, Balzano G, Zebri A, Villa E. Pancreatic cancer resection in elderly patients. Br J Surg. 1998;85:607–10.PubMedCrossRef
9.
go back to reference Bottger TC, Engelmann R, Junginger T. Is age a risk factor for major pancreatic surgery? An analysis of 300 resections. Hepatogastroenterol. 1999;46:2589–98. Bottger TC, Engelmann R, Junginger T. Is age a risk factor for major pancreatic surgery? An analysis of 300 resections. Hepatogastroenterol. 1999;46:2589–98.
10.
go back to reference Bathe OF, Levi D, Caldera H, Franceschi D, Raez L, Patel A, et al. Radical resection of periampullary tumors in the elderly: evaluation of long-term results. World J Surg. 2000;24:353–8.PubMedCrossRef Bathe OF, Levi D, Caldera H, Franceschi D, Raez L, Patel A, et al. Radical resection of periampullary tumors in the elderly: evaluation of long-term results. World J Surg. 2000;24:353–8.PubMedCrossRef
11.
go back to reference Lightner AM, Glasgow RE, Jordan TH, Krassner AD, Way LW, Mulvihill SJ, et al. Pancreatic resection in the elderly. J Am Coll Surg. 2004;198:697–706.PubMedCrossRef Lightner AM, Glasgow RE, Jordan TH, Krassner AD, Way LW, Mulvihill SJ, et al. Pancreatic resection in the elderly. J Am Coll Surg. 2004;198:697–706.PubMedCrossRef
12.
go back to reference Sohn TA, Yeo CJ, Cameron JL, Lillemoe KD, Talamini MA, Hruban RH, et al. Should pancreaticoduodenectomy be performed in octogenarians? J Gastrointest Surg. 1998;2:207–16.PubMedCrossRef Sohn TA, Yeo CJ, Cameron JL, Lillemoe KD, Talamini MA, Hruban RH, et al. Should pancreaticoduodenectomy be performed in octogenarians? J Gastrointest Surg. 1998;2:207–16.PubMedCrossRef
13.
go back to reference Finlayson E, Fan Z, Birkmeyer JD. Outcomes in octogenarians undergoing high-risk cancer operation: a national study. J Am Coll Surg. 2007;205:729–34.PubMedCrossRef Finlayson E, Fan Z, Birkmeyer JD. Outcomes in octogenarians undergoing high-risk cancer operation: a national study. J Am Coll Surg. 2007;205:729–34.PubMedCrossRef
14.
go back to reference Riall TS, Reddy DM, Nealon WH, Goodwin JS. The effect of age on short-term outcomes after pancreatic resection: a population-based study. Ann Surg. 2008;248:459–67.PubMed Riall TS, Reddy DM, Nealon WH, Goodwin JS. The effect of age on short-term outcomes after pancreatic resection: a population-based study. Ann Surg. 2008;248:459–67.PubMed
15.
go back to reference Makary MA, Winter JM, Cameron JL, Campbell KA, Chang D, Cunningham SC, et al. Pancreaticoduodenectomy in the very elderly. J Gastrointest Surg. 2006;10:347–56.PubMedCrossRef Makary MA, Winter JM, Cameron JL, Campbell KA, Chang D, Cunningham SC, et al. Pancreaticoduodenectomy in the very elderly. J Gastrointest Surg. 2006;10:347–56.PubMedCrossRef
16.
go back to reference Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M. Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg. 2008;15:41–54.PubMedCrossRef Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M. Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg. 2008;15:41–54.PubMedCrossRef
17.
go back to reference Kawai M, Uchiyama K, Tani M, Onishi H, Kinoshita H, Ueno M, et al. Clinicopathological features of malignant intraductal papillary mucinous tumors of the pancreas: the differential diagnosis from benign entities. Arch Surg. 2004;139:188–92.PubMedCrossRef Kawai M, Uchiyama K, Tani M, Onishi H, Kinoshita H, Ueno M, et al. Clinicopathological features of malignant intraductal papillary mucinous tumors of the pancreas: the differential diagnosis from benign entities. Arch Surg. 2004;139:188–92.PubMedCrossRef
18.
go back to reference Kawarada Y, Isaji S. Modified standard (D1 + a) pancreaticoduodenectomy for pancreatic cancer. J Gastrointest Surg. 2000;4:227–8.PubMedCrossRef Kawarada Y, Isaji S. Modified standard (D1 + a) pancreaticoduodenectomy for pancreatic cancer. J Gastrointest Surg. 2000;4:227–8.PubMedCrossRef
19.
go back to reference Tani M, Onishi H, Kinoshita H, Kawai M, Ueno M, Hama T, et al. The evaluation of duct-to-mucosal pancreaticojejunostomy in pancreaticoduodenectomy. World J Surg. 2005;29:76–9.PubMedCrossRef Tani M, Onishi H, Kinoshita H, Kawai M, Ueno M, Hama T, et al. The evaluation of duct-to-mucosal pancreaticojejunostomy in pancreaticoduodenectomy. World J Surg. 2005;29:76–9.PubMedCrossRef
20.
go back to reference Tani M, Terasawa H, Kawai M, Ina S, Hirono S, Uchiyama K, et al. Improvement of delayed gastric emptying in pylorus-preserving pancreaticoduodenectomy: results of a prospective, randomized, controlled trial. Ann Surg. 2006;243:316–20.PubMedCrossRef Tani M, Terasawa H, Kawai M, Ina S, Hirono S, Uchiyama K, et al. Improvement of delayed gastric emptying in pylorus-preserving pancreaticoduodenectomy: results of a prospective, randomized, controlled trial. Ann Surg. 2006;243:316–20.PubMedCrossRef
21.
go back to reference Tani M, Kawai M, Terasawa H, Ueno M, Hama T, Hirono S, et al. Complications with reconstruction procedures in pylorus-preserving pancreaticoduodenectomy. World J Surg. 2005;29:881–4.PubMedCrossRef Tani M, Kawai M, Terasawa H, Ueno M, Hama T, Hirono S, et al. Complications with reconstruction procedures in pylorus-preserving pancreaticoduodenectomy. World J Surg. 2005;29:881–4.PubMedCrossRef
22.
go back to reference Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, et al. Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg. 2006;244:1–7.PubMedCrossRef Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, et al. Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg. 2006;244:1–7.PubMedCrossRef
23.
go back to reference Büchler MW, Friess H, Wagner M, Kulli C, Wagener V, Z’graggen K. Pancreatic fistula after pancreatic head resection. Br J Surg. 2000;87:883–9.PubMedCrossRef Büchler MW, Friess H, Wagner M, Kulli C, Wagener V, Z’graggen K. Pancreatic fistula after pancreatic head resection. Br J Surg. 2000;87:883–9.PubMedCrossRef
24.
go back to reference Neoptolemos JP, Russell RCG, Bramhall S, Theis B. Low mortality following resection for pancreatic and periampullary tumours in 1026 patients: UK survey of specialist pancreatic units. Br J Surg. 1997;84:1370–6.PubMedCrossRef Neoptolemos JP, Russell RCG, Bramhall S, Theis B. Low mortality following resection for pancreatic and periampullary tumours in 1026 patients: UK survey of specialist pancreatic units. Br J Surg. 1997;84:1370–6.PubMedCrossRef
25.
go back to reference Okabayashi T, Kobayashi M, Nishimori I, Sugimoto T, Onishi S, Hanazaki K. Risk factors, predictors and prevention of pancreatic fistula formation after pancreatoduodenectomy. J Hepatobiliary Pancreat Surg. 2007;14:557–63.PubMedCrossRef Okabayashi T, Kobayashi M, Nishimori I, Sugimoto T, Onishi S, Hanazaki K. Risk factors, predictors and prevention of pancreatic fistula formation after pancreatoduodenectomy. J Hepatobiliary Pancreat Surg. 2007;14:557–63.PubMedCrossRef
26.
go back to reference Reid-Lombardo KM, Farnell MB, Crippa S, Barnett M, Maupin G, Bassi C, et al. Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1,507 patients: a report from the pancreatic anastomotic leak study group. J Hepatobiliary Pancreat Surg. 2007;11:1451–9. Reid-Lombardo KM, Farnell MB, Crippa S, Barnett M, Maupin G, Bassi C, et al. Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1,507 patients: a report from the pancreatic anastomotic leak study group. J Hepatobiliary Pancreat Surg. 2007;11:1451–9.
27.
go back to reference Detsky AS, Baker JP, O’Rourke K, Johnston N, Whitwell J, Mendelson RA, et al. Predicting nutrition-associated complications for patients undergoing gastrointestinal surgery. J Parenter Enteral Nutr. 1987;11:440–6.CrossRef Detsky AS, Baker JP, O’Rourke K, Johnston N, Whitwell J, Mendelson RA, et al. Predicting nutrition-associated complications for patients undergoing gastrointestinal surgery. J Parenter Enteral Nutr. 1987;11:440–6.CrossRef
28.
go back to reference Covinsky K, Martin G, Beyth RJ. The relationship between clinical assessments of nutritional status and adverse outcomes in older hospitalized patients. J Am Geriatr Soc. 1999;47:532–8.PubMed Covinsky K, Martin G, Beyth RJ. The relationship between clinical assessments of nutritional status and adverse outcomes in older hospitalized patients. J Am Geriatr Soc. 1999;47:532–8.PubMed
29.
go back to reference Ament R. The expanding role of the American Society of Anesthesiologists. Anesthesiology. 1976;45:475–6.PubMedCrossRef Ament R. The expanding role of the American Society of Anesthesiologists. Anesthesiology. 1976;45:475–6.PubMedCrossRef
30.
go back to reference Audisio R, Ramesh H, Longo W, Zbar A, Pope D. Preoperative assessment of surgical risk in oncogeriatric patients. Oncologist. 2005;10:262–8.PubMedCrossRef Audisio R, Ramesh H, Longo W, Zbar A, Pope D. Preoperative assessment of surgical risk in oncogeriatric patients. Oncologist. 2005;10:262–8.PubMedCrossRef
31.
go back to reference Yamaguchi K, Tanaka M, Chijiiwa K, Nagakawa T, Imamura M, Takada T. Early and late complications of pylorus-preserving pancreatoduodenectomy in Japan 1998. J Hepatobiliary Pancreat Surg. 1999;6:303–11.PubMedCrossRef Yamaguchi K, Tanaka M, Chijiiwa K, Nagakawa T, Imamura M, Takada T. Early and late complications of pylorus-preserving pancreatoduodenectomy in Japan 1998. J Hepatobiliary Pancreat Surg. 1999;6:303–11.PubMedCrossRef
32.
go back to reference Scurtu R, Bachellier P, Oussoultzoglow E, Rosso E, Maroni R, Jaeck D. Outcome after pancreaticoduodenectomy for cancer in elderly patients. J Gastrointest Surg. 2006;10:813–22.PubMedCrossRef Scurtu R, Bachellier P, Oussoultzoglow E, Rosso E, Maroni R, Jaeck D. Outcome after pancreaticoduodenectomy for cancer in elderly patients. J Gastrointest Surg. 2006;10:813–22.PubMedCrossRef
33.
go back to reference Brennan MF, Kattan MW, Klimstra D, Conlon K. Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas. Ann Surg. 2004;240:293–8.PubMedCrossRef Brennan MF, Kattan MW, Klimstra D, Conlon K. Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas. Ann Surg. 2004;240:293–8.PubMedCrossRef
Metadata
Title
A pancreaticoduodenectomy is acceptable for periampullary tumors in the elderly, even in patients over 80 years of age
Authors
Masaji Tani
Manabu Kawai
Seiko Hirono
Shinomi Ina
Motoki Miyazawa
Ryohei Nishioka
Atsushi Shimizu
Kazuhisa Uchiyama
Hiroki Yamaue
Publication date
01-09-2009
Publisher
Springer Japan
Published in
Journal of Hepato-Biliary-Pancreatic Sciences / Issue 5/2009
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI
https://doi.org/10.1007/s00534-009-0106-6

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