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Supportive Care in Cancer
Published in: Supportive Care in Cancer 10/2019

01-10-2019 | Review Article

Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis

Authors: Nadia Miladi, Richi Dossa, Maman Joyce Dogba, Marie Immacula Fabienne Cléophat-Jolicoeur, Bruno Gagnon

Published in: Supportive Care in Cancer | Issue 10/2019

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Abstract

Background

Cognitive impairment is recognized as a common symptom experienced by cancer survivors which impacts on quality of life (QoL) and day-to-day activities. One of the treatment options is the use of psychostimulants but the evidence supporting its use remains unclear.

Objectives

To identify the level of evidence of psychostimulants’ effect on the management of cognitive impairment in adult cancer survivors.

Methods

Electronic databases (MEDLINE, EMBASE, CENTRAL, CINAHL) and reference lists of relevant reviews were searched from inception to December 2017, with no language restrictions applied. Randomized controlled trials (RCTs), evaluating the effect of psychostimulants on cognitive impairment among cancer patients with no primary or secondary brain tumor or brain radiation, were included. The primary outcome was cognitive function changes, whereas secondary outcomes were adverse events (AEs) and QoL.

Results

Six RCTs were included: three studies investigating methylphenidate and three modafinil, with a total of 244 and 146 patients, respectively. Due to important differences in methodologies between studies, a meta-analysis was assumed inappropriate for the primary outcome. A narrative synthesis was performed. One study using methylphenidate and two using modafinil demonstrated improvements in some cognitive functions as measured by objective cognitive assessment tests. Psychostimulants did not improve QoL and were not associated with more AEs.

Conclusion

To date, limited evidence is available to estimate the usefulness (or lack) of psychostimulants on cognitive function in this population.
Appendix
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Metadata
Title
Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis
Authors
Nadia Miladi
Richi Dossa
Maman Joyce Dogba
Marie Immacula Fabienne Cléophat-Jolicoeur
Bruno Gagnon
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 10/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-019-04907-w

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