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01-11-2019 | Pleural Mesothelioma | Original Article

Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma

Authors: Takashi Tanaka, Shinichiro Morishita, Masaki Hashimoto, Toru Nakamichi, Yuki Uchiyama, Seiki Hasegawa, Kazuhisa Domen

Published in: Supportive Care in Cancer | Issue 11/2019

Abstract

Purpose

According to reports, patients with lung cancer have decreased pulmonary function and exercise capacity after surgery. However, to date, physical function and health-related quality of life (HRQOL) after surgery for malignant pleural mesothelioma (MPM) have not been evaluated in detail in the convalescent phase. This study aimed to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D) in the convalescent phase.

Methods

The study included 16 male MPM patients who underwent P/D between September 2014 and August 2016. Physical function was assessed based on handgrip and knee extensor strengths, the six-minute walk distance (6MWD), and pulmonary function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). HRQOL was assessed using the Medical Outcome Study 36-item Short Form Health Survey (SF-36). The assessment was performed preoperatively, postoperatively, and 1-year after surgery.

Results

The 6MWD, FVC, and FEV1 values 1-year postoperatively improved significantly compared with baseline (P < 0.05 all). Additionally, the scores of six of the eight SF-36 domains were significantly improved 1 year after P/D: physical functioning, body pain, general health, vitality, social functioning, and mental health (all P < 0.05). 6MWD, FVC, and FEV1 were correlated with vitality, mental health, and physical functioning (P < 0.05 all).

Conclusions

Patients with MPM who underwent P/D showed improved physical function and HRQOL compared with postoperative values in the convalescent phase. Physicians, nurses, and rehabilitation staff should note these findings, which may provide insight into the development of customized rehabilitation strategies in the convalescent phase for such patients.

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Title: Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma
Authors: Takashi Tanaka
Shinichiro Morishita
Masaki Hashimoto
Toru Nakamichi
Yuki Uchiyama
Seiki Hasegawa
Kazuhisa Domen
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keywords: Pleural Mesothelioma
Pleural Mesothelioma
Pleurectomy
Published in: Supportive Care in Cancer / Issue 11/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-04704-5

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