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01-02-2016 | Original Article

CD34+ selection and the severity of oropharyngeal mucositis in total body irradiation-based allogeneic stem cell transplantation

Authors: Ankit Anand, Prathima Anandi, Natasha A. Jain, Kit Lu, Neil Dunavin, Christopher S. Hourigan, Robert Q. Le, Puja D. Chokshi, Sawa Ito, David F. Stroncek, Marianna Sabatino, A. John Barrett, Minoo Battiwalla

Published in: Supportive Care in Cancer | Issue 2/2016

Abstract

Objective

The purpose of the present study was to evaluate the impact of ex vivo T cell depleted (TCD) by CD34+ selection on the incidence and severity of oropharyngeal mucositis (OM) after myeloablative allogeneic stem cell transplant (allo-SCT) with total body irradiation (TBI) conditioning. This approach has the advantage of avoiding methotrexate for graft versus host disease (GVHD) prophylaxis.

Patients and Methods

We analyzed the incidence and severity of OM in a cohort of 105 consecutive patients who underwent CD34+ selected (peripheral blood stem cells (PBSCs) from human leukocyte antigen (HLA)-identical siblings) allo-SCT with total body irradiation (TBI) conditioning. OM was graded by the World Health organization (WHO) and the Bearman regimen-related toxicity (RRT) scales.

Results

The incidence of WHO grade 3–4 OM was 34.3 %. There were no cases of grade 3–4 OM by the RRT scale. Significant correlation was found between the severity of OM and the use of intravenous (IV) narcotic medications (r ² = 0.15, p = 0.004), total parenteral nutrition (TPN; r ² = 0.68, p < 0.001), and hospital length of stay (LOS) (r ² = 0.12, p = 0.01).

Discussion

TBI-induced OM can inflict significant morbidity in the early transplant period, and the incidence of WHO grade 3–4 OM can exceed 50 % when methotrexate is used for GVHD prophylaxis. In the CD34+ selected setting, methotrexate is avoided and the incidence of WHO grade 3–4 OM, use of TPN, and need for narcotic analgesia appear to be lower than historic evidence from standard T-replete allogeneic transplantation.

Conclusion

We conclude that toxicity from OM is tolerable in CD34+ selected allo-SCT and should be prospectively measured in randomized trials comparing CD34+ selection versus T-replete transplantation.

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Title: CD34+ selection and the severity of oropharyngeal mucositis in total body irradiation-based allogeneic stem cell transplantation
Authors: Ankit Anand
Prathima Anandi
Natasha A. Jain
Kit Lu
Neil Dunavin
Christopher S. Hourigan
Robert Q. Le
Puja D. Chokshi
Sawa Ito
David F. Stroncek
Marianna Sabatino
A. John Barrett
Minoo Battiwalla
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 2/2016
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-015-2848-9

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Abstract

Objective

Patients and Methods

Results

Discussion

Conclusion

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