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01-04-2015 | Original Article

Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation

Authors: Takahiro Takekiyo, Koichiro Dozono, Takayuki Mitsuishi, Yoshihiro Murayama, Ayako Maeda, Nobuaki Nakano, Ayumu Kubota, Masahito Tokunaga, Shogo Takeuchi, Yoshifusa Takatsuka, Atae Utsunomiya

Published in: Supportive Care in Cancer | Issue 4/2015

Abstract

Purpose

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with transplant-related toxicities, which may have a profound impact on a patient’s physical functioning and body composition. In order to analyze the effect of exercise therapy on muscle mass and physical functioning in patients receiving allo-HSCT, we measured muscle mass and physical functioning before and after allo-HSCT.

Methods

Eighty-six patients who had undergone allo-HSCT between February 2010 and September 2013 at Imamura Bun-in Hospital participated in this study. Physical therapists performed exercise therapy with patients 5 days a week, starting 2 weeks before allo-HSCT. Body composition, 6-min walk test (6MWT) scores, and handgrip strength were evaluated 2 weeks before allo-HSCT and 6 weeks after allo-HSCT.

Results

Thirty-five patients were available for evaluation 2 weeks before and 6 weeks after allo-HSCT. The 6MWT (p = 0.005) and handgrip strength (p < 0.001) significantly decreased after allo-HSCT. Although upper extremity muscle mass (p = 0.001) and trunk muscle mass (p < 0.001) significantly decreased after allo-HSCT, lower extremity muscle mass remained unchanged.

Conclusions

In this study, it is suggested that exercise therapy may be effective for maintaining lower extremity muscle mass in patients undergoing allo-HSCT.

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Title: Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Takahiro Takekiyo
Koichiro Dozono
Takayuki Mitsuishi
Yoshihiro Murayama
Ayako Maeda
Nobuaki Nakano
Ayumu Kubota
Masahito Tokunaga
Shogo Takeuchi
Yoshifusa Takatsuka
Atae Utsunomiya
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 4/2015
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-014-2425-7

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Purpose

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