Skip to main content
Top
Published in: Supportive Care in Cancer 5/2013

01-05-2013 | Review Article

The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of use for identifying low-risk febrile neutropenic cancer patients

Authors: Jean Klastersky, Marianne Paesmans

Published in: Supportive Care in Cancer | Issue 5/2013

Login to get access

Abstract

The Multinational Association for Supportive Care in Cancer risk index score developed, through a multinational collaboration, was published in 2000 with the aim to identify patients with chemotherapy-induced febrile neutropenia at low risk of serious medical complication development. It has been endorsed as a reliable tool since 2002 by Infectious Diseases Society of America. Ten years after, we thought worth to review its use, its characteristics in the external validations that occurred after the initial publication and also to review how the recognition of a group of patients at low risk has changed the management of febrile neutropenia. We also raise the issue of identification of high-risk patients that remains a challenge today.
Literature
1.
go back to reference Bodey GP, Buckley M, Sathe YS et al (1996) Quantitative relationship between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64:328–340 Bodey GP, Buckley M, Sathe YS et al (1996) Quantitative relationship between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64:328–340
2.
go back to reference Schimpff S, Satterlee W, Young VM et al (1971) Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N Engl J Med 284:161–165CrossRef Schimpff S, Satterlee W, Young VM et al (1971) Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N Engl J Med 284:161–165CrossRef
3.
go back to reference Klastersky J (1983) Empiric treatment of infections in neutropenic patients with cancer. Rev Infect Dis 5:S21–S23PubMedCrossRef Klastersky J (1983) Empiric treatment of infections in neutropenic patients with cancer. Rev Infect Dis 5:S21–S23PubMedCrossRef
4.
go back to reference The EORTC International Antimicrobial Therapy Cooperative Group (1978) Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. N Engl J Med 317:1692–1698 The EORTC International Antimicrobial Therapy Cooperative Group (1978) Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. N Engl J Med 317:1692–1698
5.
go back to reference Talcott JA, Siegel RD, Finberg R et al (1992) Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule. J Clin Oncol 10:316–322PubMed Talcott JA, Siegel RD, Finberg R et al (1992) Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule. J Clin Oncol 10:316–322PubMed
6.
go back to reference Talcott JA, Whalen A, Clark J et al (1994) Home antibiotic-therapy for low-risk cancer patients with fever and neutropenia-a pilot-study of 30 patients based on a validated prediction rule. J Clin Oncol 12:107–114PubMed Talcott JA, Whalen A, Clark J et al (1994) Home antibiotic-therapy for low-risk cancer patients with fever and neutropenia-a pilot-study of 30 patients based on a validated prediction rule. J Clin Oncol 12:107–114PubMed
7.
go back to reference Kern WV, Cometta A, De Bock R et al (1999) Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. N Engl J Med 314:312–318CrossRef Kern WV, Cometta A, De Bock R et al (1999) Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. N Engl J Med 314:312–318CrossRef
8.
go back to reference Freifeld A, Marchigiani D, Walsh T et al (1999) A double blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. N Engl J Med 341:305–3011PubMedCrossRef Freifeld A, Marchigiani D, Walsh T et al (1999) A double blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. N Engl J Med 341:305–3011PubMedCrossRef
9.
go back to reference Klastersky J, Paesmans M, Rubenstein EB et al (2000) The multinational association for supportive care in cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol 18:3038–3051PubMed Klastersky J, Paesmans M, Rubenstein EB et al (2000) The multinational association for supportive care in cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol 18:3038–3051PubMed
10.
go back to reference Naurois J, Novitzky-Basso I, Gill JM et al (2010) Management of febrile neutropenia: ESMO Clinical Practice Guidelines. Ann Oncol 21:252–256CrossRef Naurois J, Novitzky-Basso I, Gill JM et al (2010) Management of febrile neutropenia: ESMO Clinical Practice Guidelines. Ann Oncol 21:252–256CrossRef
11.
go back to reference Hughes WT, Amstrong D, Bodey GP et al (2002) 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730–751PubMedCrossRef Hughes WT, Amstrong D, Bodey GP et al (2002) 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730–751PubMedCrossRef
12.
go back to reference Freifeld A, Bow E, Sepkowitz K et al (2011) Executive summary: clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by infectious diseases society of America. Clin Infect Dis 52:e56–e93PubMedCrossRef Freifeld A, Bow E, Sepkowitz K et al (2011) Executive summary: clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by infectious diseases society of America. Clin Infect Dis 52:e56–e93PubMedCrossRef
13.
go back to reference Uys A, Rapoport B, Anderson R (2004) Febrile neutropenia: a prospective study to validate the Multinational Association of Supportive Care of Cancer (MASCC) risk index score. Support Care Cancer 12:555–560PubMedCrossRef Uys A, Rapoport B, Anderson R (2004) Febrile neutropenia: a prospective study to validate the Multinational Association of Supportive Care of Cancer (MASCC) risk index score. Support Care Cancer 12:555–560PubMedCrossRef
14.
go back to reference Cherif H, Johansson E, Björkholm M et al (2006) The feasibility of early hospital discharge with oral antimicrobial therapy in low risk patients with febrile neutropenia following chemotherapy for hematologic malignancies. Haematologica 91:215–222PubMed Cherif H, Johansson E, Björkholm M et al (2006) The feasibility of early hospital discharge with oral antimicrobial therapy in low risk patients with febrile neutropenia following chemotherapy for hematologic malignancies. Haematologica 91:215–222PubMed
15.
go back to reference Baskaran ND, Gan GG, Adeeba K (2008) Applying the Multinational Association for Supportive Care in Cancer risk scoring in predicting outcome of febrile neutropenia patients in a cohort of patients. Ann Hematol 87:563–569PubMedCrossRef Baskaran ND, Gan GG, Adeeba K (2008) Applying the Multinational Association for Supportive Care in Cancer risk scoring in predicting outcome of febrile neutropenia patients in a cohort of patients. Ann Hematol 87:563–569PubMedCrossRef
16.
go back to reference Pun Hui E, Leung KS, Poon T et al (2011) Prediction of outcome in cancer patients with febrile neutropenia: a prospective validation of the Multinational Association for Supportive Care in Cancer risk index in a Chinese population and comparison with the Talcott model and artificial neural network. Support Care Cancer 19:1625–1635CrossRef Pun Hui E, Leung KS, Poon T et al (2011) Prediction of outcome in cancer patients with febrile neutropenia: a prospective validation of the Multinational Association for Supportive Care in Cancer risk index in a Chinese population and comparison with the Talcott model and artificial neural network. Support Care Cancer 19:1625–1635CrossRef
17.
go back to reference Carmona-Bayonas A, Gómez J, González-Billalabeitia E et al (2011) Prognostic evaluation of febrile neutropaenia in apparently stable adult cancer patient. Br J Cancer 105:612–617PubMedCrossRef Carmona-Bayonas A, Gómez J, González-Billalabeitia E et al (2011) Prognostic evaluation of febrile neutropaenia in apparently stable adult cancer patient. Br J Cancer 105:612–617PubMedCrossRef
18.
go back to reference Philips R, Wade R, Lehrnbecher T et al (2012) Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer. BMC Med 10:6CrossRef Philips R, Wade R, Lehrnbecher T et al (2012) Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer. BMC Med 10:6CrossRef
19.
go back to reference Paesmans M, Klastersky J, Maertens J et al (2011) Predicting febrile neutropenic patients at low risk using the MASCC score: does bacteremia matter? Support Care Cancer 19:1001–1008PubMedCrossRef Paesmans M, Klastersky J, Maertens J et al (2011) Predicting febrile neutropenic patients at low risk using the MASCC score: does bacteremia matter? Support Care Cancer 19:1001–1008PubMedCrossRef
20.
go back to reference Furno P, Bucaneve G, Del Favero A (2002) Monotherapy or aminoglycoside containing combinations for empirical antibiotic treatment of febrile neutropenia patients: a meta-analysis. Lancet 2:231–243 Furno P, Bucaneve G, Del Favero A (2002) Monotherapy or aminoglycoside containing combinations for empirical antibiotic treatment of febrile neutropenia patients: a meta-analysis. Lancet 2:231–243
21.
go back to reference Kridel R, Van Delden C, Calandra T et al (2008) Antibiothérapie empirique lors de neutropénie febrile. Rev Med Suisse 4:914–919PubMed Kridel R, Van Delden C, Calandra T et al (2008) Antibiothérapie empirique lors de neutropénie febrile. Rev Med Suisse 4:914–919PubMed
22.
go back to reference Mebis J, Goossens H, Berneman ZN (2010) Antibiotic management of febrile neutropenia: current developments and future directions. J Chemother 22:5–12PubMed Mebis J, Goossens H, Berneman ZN (2010) Antibiotic management of febrile neutropenia: current developments and future directions. J Chemother 22:5–12PubMed
23.
go back to reference Event C, Taillade L, Spano JP et al (2010) Neutropénie fébrile chez le patient adulte atteint de tumeur solide: revue de la littérature pour une gestion rationnelle et optimale. Bull Cancer 97:547–557 Event C, Taillade L, Spano JP et al (2010) Neutropénie fébrile chez le patient adulte atteint de tumeur solide: revue de la littérature pour une gestion rationnelle et optimale. Bull Cancer 97:547–557
24.
go back to reference Tam CS, O’Reilly M, Andresen D et al (2011) Use of empiric antimicrobial therapy in neutropenic fever. Intern Med J 41:90–101PubMedCrossRef Tam CS, O’Reilly M, Andresen D et al (2011) Use of empiric antimicrobial therapy in neutropenic fever. Intern Med J 41:90–101PubMedCrossRef
25.
go back to reference Rolston K, Frisbee-Hume S, Patel S et al (2010) Oral moxifloxacin for outpatients treatment of low-risk, febrile neutropenic patients. Support Care Cancer 18:89–94PubMedCrossRef Rolston K, Frisbee-Hume S, Patel S et al (2010) Oral moxifloxacin for outpatients treatment of low-risk, febrile neutropenic patients. Support Care Cancer 18:89–94PubMedCrossRef
26.
go back to reference Zuckermann J, Moreira L, Stoll P (2008) Compliance with a critical pathway for the management of febrile neutropenia and impact on clinical outcomes. Ann Hematol 87:139–145PubMedCrossRef Zuckermann J, Moreira L, Stoll P (2008) Compliance with a critical pathway for the management of febrile neutropenia and impact on clinical outcomes. Ann Hematol 87:139–145PubMedCrossRef
27.
go back to reference Sebban C, Dussart S, Fuhrmann C et al (2008) Oral moxifloxacin or intravenous ceftriaxone for the treatment of low-risk neutropenic fever in cancer patients suitable for early hospital discharge. Support Care Cancer 16:1017–1023PubMedCrossRef Sebban C, Dussart S, Fuhrmann C et al (2008) Oral moxifloxacin or intravenous ceftriaxone for the treatment of low-risk neutropenic fever in cancer patients suitable for early hospital discharge. Support Care Cancer 16:1017–1023PubMedCrossRef
28.
go back to reference Innes HE, Smith DB, O’Reilly SM et al (2003) Oral antibiotics with early hospital discharge compared with in-patients intravenous antibiotics for low-risk febrile neutropenia in patients with cancer: a prospective randomized controlled single centre study. Br J Cancer 89:43–49PubMedCrossRef Innes HE, Smith DB, O’Reilly SM et al (2003) Oral antibiotics with early hospital discharge compared with in-patients intravenous antibiotics for low-risk febrile neutropenia in patients with cancer: a prospective randomized controlled single centre study. Br J Cancer 89:43–49PubMedCrossRef
29.
go back to reference Innes H, Lim S, Hall A et al (2008) Management of febrile neutropenia in solid tumours and lymphomas using the Multinational Association for Supportive Care in Cancer (MASCC) risk index: feasibility and safety in routine clinical practice. Support Care Cancer 16:485–4941PubMedCrossRef Innes H, Lim S, Hall A et al (2008) Management of febrile neutropenia in solid tumours and lymphomas using the Multinational Association for Supportive Care in Cancer (MASCC) risk index: feasibility and safety in routine clinical practice. Support Care Cancer 16:485–4941PubMedCrossRef
30.
go back to reference Klastersky J, Paesmans M, Georgala A et al (2006) Outpatient oral antibiotics for febrile neutropenic cancer patients using a score predictive for complications. J Clin Oncol 24:4129–4134PubMedCrossRef Klastersky J, Paesmans M, Georgala A et al (2006) Outpatient oral antibiotics for febrile neutropenic cancer patients using a score predictive for complications. J Clin Oncol 24:4129–4134PubMedCrossRef
31.
go back to reference Brack E, Bodmer N, Simon A et al (2012) First-day step-down to oral outpatient treatment versus continued standard treatment in children with cancer and low-risk fever in neutropenia. A randomized controlled trial within the multicenter SPOG 2003 FN study. Pediatr Blood Cancer 59(3):423–430. doi:10.1002/pbc.24076 PubMedCrossRef Brack E, Bodmer N, Simon A et al (2012) First-day step-down to oral outpatient treatment versus continued standard treatment in children with cancer and low-risk fever in neutropenia. A randomized controlled trial within the multicenter SPOG 2003 FN study. Pediatr Blood Cancer 59(3):423–430. doi:10.​1002/​pbc.​24076 PubMedCrossRef
32.
go back to reference Carstensen M, Sorensen JB (2008) Outpatient management of febrile neutropenia: time to revise the present treatment strategy. J Support Oncol 6:199–208PubMed Carstensen M, Sorensen JB (2008) Outpatient management of febrile neutropenia: time to revise the present treatment strategy. J Support Oncol 6:199–208PubMed
33.
go back to reference Teuffel O, Ethier MC, Alibhal SM et al (2011) Outpatient management of cancer patients with febrile neutropenia: a systematic review and meta-analysis. Ann Oncol 22:2358–2365PubMedCrossRef Teuffel O, Ethier MC, Alibhal SM et al (2011) Outpatient management of cancer patients with febrile neutropenia: a systematic review and meta-analysis. Ann Oncol 22:2358–2365PubMedCrossRef
34.
go back to reference Teuffel E, Amir, Alibhai S et al (2011) Cost-effectiveness of outpatient treatment for febrile neutropaenia in adult cancer patients. B JCancer 104:1377–1383CrossRef Teuffel E, Amir, Alibhai S et al (2011) Cost-effectiveness of outpatient treatment for febrile neutropaenia in adult cancer patients. B JCancer 104:1377–1383CrossRef
35.
go back to reference Elting L, Lu C, Escalante C et al (2008) Outcomes and cost of outpatient or inpatient management of 712 patients with febrile neutropenia. J Clin Oncol 26:606–611PubMedCrossRef Elting L, Lu C, Escalante C et al (2008) Outcomes and cost of outpatient or inpatient management of 712 patients with febrile neutropenia. J Clin Oncol 26:606–611PubMedCrossRef
36.
go back to reference Talcott J, Yeap B, Clark J et al (2011) Safety of early discharge for low-risk patients with febrile neutropenia: a multicenter randomized controlled trial. J Clin Oncol 29:3977–3988PubMedCrossRef Talcott J, Yeap B, Clark J et al (2011) Safety of early discharge for low-risk patients with febrile neutropenia: a multicenter randomized controlled trial. J Clin Oncol 29:3977–3988PubMedCrossRef
37.
go back to reference Hendricks A, Trice Loggers E, Talcott J (2011) Costs of home versus inpatient treatment for fever and neutropenia: analysis of a multicenter randomized trial. J Clin Oncol 29:3984–3988PubMedCrossRef Hendricks A, Trice Loggers E, Talcott J (2011) Costs of home versus inpatient treatment for fever and neutropenia: analysis of a multicenter randomized trial. J Clin Oncol 29:3984–3988PubMedCrossRef
38.
go back to reference Teuffel O, Cheng S, Ethier M et al (2012) Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients. Support Care Cancer 20(11):2755–2764PubMedCrossRef Teuffel O, Cheng S, Ethier M et al (2012) Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients. Support Care Cancer 20(11):2755–2764PubMedCrossRef
39.
go back to reference Diorio C, Martino J, Boydell K et al (2011) Parental perspectives on inpatient versus outpatient management of pediatric febrile neutropenia. J Pediatr Oncol Nurs 28:355–362PubMedCrossRef Diorio C, Martino J, Boydell K et al (2011) Parental perspectives on inpatient versus outpatient management of pediatric febrile neutropenia. J Pediatr Oncol Nurs 28:355–362PubMedCrossRef
40.
go back to reference Manji A, Beyene J, Dupuis R et al (2012) Outpatient and oral antibiotic management of low-risk febrile neutropenia are effective in children—a systematic review of prospective trials. Support Care Cancer 20:1135–1145PubMedCrossRef Manji A, Beyene J, Dupuis R et al (2012) Outpatient and oral antibiotic management of low-risk febrile neutropenia are effective in children—a systematic review of prospective trials. Support Care Cancer 20:1135–1145PubMedCrossRef
41.
go back to reference Sung L, Alibhai S, Ethier MC et al (2012) Discrete choice experiment produced estimates of acceptable risks of therapeutic options in cancer patients with febrile neutropenia. J Clin Epidemiol 65:627–634PubMedCrossRef Sung L, Alibhai S, Ethier MC et al (2012) Discrete choice experiment produced estimates of acceptable risks of therapeutic options in cancer patients with febrile neutropenia. J Clin Epidemiol 65:627–634PubMedCrossRef
42.
go back to reference Freifeld A, Sankaranarayanan J, Ullrich F et al (2008) Clinical practice patterns of managing low-risk adult febrile neutropenia during cancer chemotherapy in the USA. Support Care Cancer 16:181–191PubMedCrossRef Freifeld A, Sankaranarayanan J, Ullrich F et al (2008) Clinical practice patterns of managing low-risk adult febrile neutropenia during cancer chemotherapy in the USA. Support Care Cancer 16:181–191PubMedCrossRef
43.
go back to reference Rubenstein EB, Rolston K, Benjamin RS et al (1993) Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer. Cancer 71:3640–3646PubMedCrossRef Rubenstein EB, Rolston K, Benjamin RS et al (1993) Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer. Cancer 71:3640–3646PubMedCrossRef
44.
go back to reference Klastersky J, Ameye L, Maertens et al (2007) Bacteraemia in febrile neutropenic cancer patients. Int J Antimicrob Agents 30(Suppl 1):S51–S59PubMedCrossRef Klastersky J, Ameye L, Maertens et al (2007) Bacteraemia in febrile neutropenic cancer patients. Int J Antimicrob Agents 30(Suppl 1):S51–S59PubMedCrossRef
45.
go back to reference Blot F, Nitenberg G (2004) Patients neutropéniques fébriles à bas et haut risques. Presse Med 33:473–479CrossRef Blot F, Nitenberg G (2004) Patients neutropéniques fébriles à bas et haut risques. Presse Med 33:473–479CrossRef
46.
go back to reference Sammut S, Mazhar D (2012) Management of febrile neutropenia in an acute oncology service. Q J Med 105:327–336CrossRef Sammut S, Mazhar D (2012) Management of febrile neutropenia in an acute oncology service. Q J Med 105:327–336CrossRef
47.
go back to reference André S, Taboulet P, Elie C (2010) Febrile neutropenia in French emergency departments: results of a prospective multicentre survey. Crit Care 14:R68PubMedCrossRef André S, Taboulet P, Elie C (2010) Febrile neutropenia in French emergency departments: results of a prospective multicentre survey. Crit Care 14:R68PubMedCrossRef
48.
go back to reference Lim C, Bawden J, Wing A et al (2012) Febrile neutropenia in EDs: the role of an electronic clinical practice guideline. Am J Emerg Med 30(1):5, 11, 11.e1–5PubMedCrossRef Lim C, Bawden J, Wing A et al (2012) Febrile neutropenia in EDs: the role of an electronic clinical practice guideline. Am J Emerg Med 30(1):5, 11, 11.e1–5PubMedCrossRef
49.
go back to reference Rivers E, Nguyen B, Havstad S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377PubMedCrossRef Rivers E, Nguyen B, Havstad S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377PubMedCrossRef
50.
go back to reference Ahn S, Lee YS, Chun YH et al (2011) Predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia. Support Care Cancer 19:1151–1158PubMedCrossRef Ahn S, Lee YS, Chun YH et al (2011) Predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia. Support Care Cancer 19:1151–1158PubMedCrossRef
51.
go back to reference Kim D, Lee YS, Ahn S et al (2011) The usefulness of procalcitonin and C-reactive protein as early diagnostic markers of bacteremia in cancer patients with febrile neutropenia. Cancer Res Treat 43:176–180PubMedCrossRef Kim D, Lee YS, Ahn S et al (2011) The usefulness of procalcitonin and C-reactive protein as early diagnostic markers of bacteremia in cancer patients with febrile neutropenia. Cancer Res Treat 43:176–180PubMedCrossRef
52.
go back to reference Uys A, Rapoport B, Meyer P et al (2007) Prediction of outcome in cancer patients with febrile neutropenia: comparison of the Multinational Association of Supportive Care in Cancer risk-index score with procalcitonin, C-reactive protein, serum amyloid A, and interleukins-1β, -6 and -10. Eur J Cancer Care (Engl) 16:475–483CrossRef Uys A, Rapoport B, Meyer P et al (2007) Prediction of outcome in cancer patients with febrile neutropenia: comparison of the Multinational Association of Supportive Care in Cancer risk-index score with procalcitonin, C-reactive protein, serum amyloid A, and interleukins-1β, -6 and -10. Eur J Cancer Care (Engl) 16:475–483CrossRef
53.
go back to reference Mato A, Luger S, Heitjan D et al (2010) Elevation in serum lactate at the time of febrile neutropenia (FN) in hemodynamically-stable patients with hematologic malignancies (HM) is associated with the development of septic shock within 48 h. Cancer Biol Ther 9:585–589PubMedCrossRef Mato A, Luger S, Heitjan D et al (2010) Elevation in serum lactate at the time of febrile neutropenia (FN) in hemodynamically-stable patients with hematologic malignancies (HM) is associated with the development of septic shock within 48 h. Cancer Biol Ther 9:585–589PubMedCrossRef
54.
go back to reference Jeddi R, Zarrouk M, Benabdennebi Y et al (2007) Predictive factors of septic shock and mortality in neutropenic patients. Hematology 12:543–548CrossRef Jeddi R, Zarrouk M, Benabdennebi Y et al (2007) Predictive factors of septic shock and mortality in neutropenic patients. Hematology 12:543–548CrossRef
55.
go back to reference Shaikh AJ, Bawany SA, Masood N et al (2011) Incidence and impact of baseline electrolyte abnormalities in patients admitted with chemotherapy induced febrile neutropenia. J Cancer 2:62–66PubMedCrossRef Shaikh AJ, Bawany SA, Masood N et al (2011) Incidence and impact of baseline electrolyte abnormalities in patients admitted with chemotherapy induced febrile neutropenia. J Cancer 2:62–66PubMedCrossRef
56.
go back to reference Nakagawa Y, Suzuki K, Masaoka T (2009) Evaluation of the risk factors for febrile neutropenia associated with hematological malignancy. J Infect Chemother 15:174–179PubMedCrossRef Nakagawa Y, Suzuki K, Masaoka T (2009) Evaluation of the risk factors for febrile neutropenia associated with hematological malignancy. J Infect Chemother 15:174–179PubMedCrossRef
57.
go back to reference Park Y, Kim D, Park S et al (2010) The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease. Leuk Res 34:294–300PubMedCrossRef Park Y, Kim D, Park S et al (2010) The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease. Leuk Res 34:294–300PubMedCrossRef
58.
go back to reference De Souza VL, Serufo JC, da Costa Rocha MO et al (2008) Performance of a modified MASCC index score for identifying low-risk febrile neutropenic cancer patients. Support Care Cancer 16:841–846CrossRef De Souza VL, Serufo JC, da Costa Rocha MO et al (2008) Performance of a modified MASCC index score for identifying low-risk febrile neutropenic cancer patients. Support Care Cancer 16:841–846CrossRef
59.
go back to reference Eun Ha Y, Song JH, Kang WK et al (2011) Clinical factors predicting bacteremia in low-risk febrile neutropenia after anti-cancer chemotherapy. Support Care Cancer 19:1761–1767CrossRef Eun Ha Y, Song JH, Kang WK et al (2011) Clinical factors predicting bacteremia in low-risk febrile neutropenia after anti-cancer chemotherapy. Support Care Cancer 19:1761–1767CrossRef
60.
go back to reference Lamoth F, Jaton K, Prod’hom G et al (2010) Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia. J Clin Microbiol 48:3510–3516PubMedCrossRef Lamoth F, Jaton K, Prod’hom G et al (2010) Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia. J Clin Microbiol 48:3510–3516PubMedCrossRef
61.
go back to reference Vänskä M, Koivula I, Hämäläinen S et al (2011) High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients. Haematologica 96:1385–1389PubMedCrossRef Vänskä M, Koivula I, Hämäläinen S et al (2011) High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients. Haematologica 96:1385–1389PubMedCrossRef
62.
go back to reference Lyman G, Kuderer N, Crawford B et al (2011) Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy. Cancer 117:1917–1927PubMedCrossRef Lyman G, Kuderer N, Crawford B et al (2011) Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy. Cancer 117:1917–1927PubMedCrossRef
63.
go back to reference Moreau M, Klasterky J, Schwarzbold A et al (2009) A general chemotherapy myelotoxicity score to predict febrile neutropenia in hematological malignancies. Ann Oncol 20:513–519PubMedCrossRef Moreau M, Klasterky J, Schwarzbold A et al (2009) A general chemotherapy myelotoxicity score to predict febrile neutropenia in hematological malignancies. Ann Oncol 20:513–519PubMedCrossRef
64.
go back to reference Lalami Y, Paesmans M, Muanza F et al (2006) Can we predict the duration of chemotherapy-induced neutropenia in febrile neutropenic patients, focusing on regimen-specific risk factors? A retrospective analysis. Ann Oncol 17:507–514PubMedCrossRef Lalami Y, Paesmans M, Muanza F et al (2006) Can we predict the duration of chemotherapy-induced neutropenia in febrile neutropenic patients, focusing on regimen-specific risk factors? A retrospective analysis. Ann Oncol 17:507–514PubMedCrossRef
65.
go back to reference Aapro MS, Cameron DA, Pettengell R et al (2006) EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumors. Eur J Cancer 42:2433–2453PubMedCrossRef Aapro MS, Cameron DA, Pettengell R et al (2006) EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumors. Eur J Cancer 42:2433–2453PubMedCrossRef
66.
67.
go back to reference Cooper K, Madan J, Whyte S et al (2011) Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: systematic review and meta-analysis. BMC Cancer 11:404PubMedCrossRef Cooper K, Madan J, Whyte S et al (2011) Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: systematic review and meta-analysis. BMC Cancer 11:404PubMedCrossRef
68.
go back to reference Klastersky J, Georgala A, Ameye L et al (2010) Febrile neutropenia (FN) in patients with solid tumors (St): is the risk of complications affected by the type of chemotherapy? Support Care Cancer 18:S67–S220 Klastersky J, Georgala A, Ameye L et al (2010) Febrile neutropenia (FN) in patients with solid tumors (St): is the risk of complications affected by the type of chemotherapy? Support Care Cancer 18:S67–S220
69.
go back to reference Klastersky J, Awada A, Aoun M et al (2009) Should the indications for the use of myeloid growth factors for the prevention of febrile neutropenia in cancer patients be extended? Curr Opin Oncol 21:297–302PubMedCrossRef Klastersky J, Awada A, Aoun M et al (2009) Should the indications for the use of myeloid growth factors for the prevention of febrile neutropenia in cancer patients be extended? Curr Opin Oncol 21:297–302PubMedCrossRef
70.
go back to reference Papaldo P, López M, Marolla P et al (2005) Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with epirubicin and cyclophosphamide. J Clin Oncol 23:6908–6918PubMedCrossRef Papaldo P, López M, Marolla P et al (2005) Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with epirubicin and cyclophosphamide. J Clin Oncol 23:6908–6918PubMedCrossRef
Metadata
Title
The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of use for identifying low-risk febrile neutropenic cancer patients
Authors
Jean Klastersky
Marianne Paesmans
Publication date
01-05-2013
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 5/2013
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-013-1758-y

Other articles of this Issue 5/2013

Supportive Care in Cancer 5/2013 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine