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Supportive Care in Cancer
Published in: Supportive Care in Cancer 5/2013

01-05-2013 | Original Article

Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients

Authors: Vanessa Fuchs-Tarlovsky, María Amanda Casillas Rivera, Karolina Alvarez Altamirano, Juan Carlos Lopez-Alvarenga, Guillermo Manuel Ceballos-Reyes

Published in: Supportive Care in Cancer | Issue 5/2013

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Abstract

Background and aim

Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxidative stress, hematological toxicity, and quality of life (QoL) in cervical cancer patients.

Methods

Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement. Plasma concentrations of malondialdehyde, free carbonyls, and blood biometry were measured. EORTC quality of life questionnaire was applied before and after oncology treatment. Student’s t test for independent samples and X 2 for categorical variables were performed.

Results

One hundred three patients were randomly assigned to receive treatment with antioxidants 49 (48 %) or placebo 54 (52.40 %). At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group (p < 0.025).

Conclusions

Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL; however, more studies are needed to study the long-term effect of this intervention.
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Metadata
Title
Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients
Authors
Vanessa Fuchs-Tarlovsky
María Amanda Casillas Rivera
Karolina Alvarez Altamirano
Juan Carlos Lopez-Alvarenga
Guillermo Manuel Ceballos-Reyes
Publication date
01-05-2013
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 5/2013
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-012-1674-6

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