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Pediatric Nephrology
Published in: Pediatric Nephrology 4/2020

01-04-2020 | Editorial Commentary

Big equation for small kidneys: a newly proposed model to estimate neonatal GFR

Authors: Abby Basalely, Diane Liu, Frederick J. Kaskel

Published in: Pediatric Nephrology | Issue 4/2020

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Excerpt

Rapid assessment of glomerular filtration rates (GFR) in infants is imperative for both drug dosing and recognition of acute kidney injury (AKI) [1‐3]. This is especially important in low birth weight and preterm neonates who have an increased risk of AKI and development of chronic kidney disease (CKD) [4]. However, obtaining accurate estimates of GFR in term and preterm infants has been challenging. Serum creatinine, the traditional biomarker of filtration, is dependent upon muscle mass and age-dependent renal excretion. Creatinine values in newborns are further complicated by the fact that infant creatinine levels are reflective of maternal creatinine levels in the first few days of life and creatinine is reabsorbed by immature tubules [5, 6]. …
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Metadata
Title
Big equation for small kidneys: a newly proposed model to estimate neonatal GFR
Authors
Abby Basalely
Diane Liu
Frederick J. Kaskel
Publication date
01-04-2020
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 4/2020
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-019-04465-7

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