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01-10-2018 | Clinical Quiz

A young child with fever and unexplained acute kidney injury: Answers

Authors: Sidharth Kumar Sethi, Arushi Nautiyal, Alka Rana, Rajan Duggal, Ashish Nandwani, Dinesh Yadav, Amit Mahapatra, Maninder Dhaliwal, Veena Raghunathan, Shyam Bihari Bansal

Published in: Pediatric Nephrology | Issue 10/2018

Excerpt

Acute kidney injury as a direct consequence of hemophagocytic lymphohistiocytosis [HLH]. CD68 positivity signifies histiocytic infiltrate. Few histiocytes also showed lymphocytic phagocytosis.

To find the cause of HLH, all infectious etiologies (e.g. typhus, malaria, dengue), malignancy and genetic sequencing to rule out primary HLH

Pulse steroids followed by oral prednisolone in view of predominant histiocytic infiltrate with tubulointerstitial nephritis

…

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Title: A young child with fever and unexplained acute kidney injury: Answers
Authors: Sidharth Kumar Sethi
Arushi Nautiyal
Alka Rana
Rajan Duggal
Ashish Nandwani
Dinesh Yadav
Amit Mahapatra
Maninder Dhaliwal
Veena Raghunathan
Shyam Bihari Bansal
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-018-3911-9

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A young child with fever and unexplained acute kidney injury: Answers

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