Skip to main content
Top
Published in: Pediatric Nephrology 3/2018

01-03-2018 | Clinical Quiz

Abdominal pain in a 5-year-old girl with bilateral nephromegaly: Answers

Authors: Hulya Nalcacioglu, Sibel Yel, Meriban Karadogan, Fatma Turkan Mutlu, Funda Bastug, Yasemin Altuner Torun

Published in: Pediatric Nephrology | Issue 3/2018

Login to get access

Abstract

Renal involvement in non-Hodgkin lymphoma is a recognized development, but it mostly follows a diagnosis of lymphoma. We describe a rare case of a T-cell-type non-Hodgkin lymphoma that first presents as nephromegaly in a 5-year-old girl admitted to the emergency department with abdominal pain. Further investigation revealed bilateral nephromegaly, but the results of blood tests, imaging studies, and bone marrow aspiration were inconclusive. During the second week of hospitalization, significant physical examination revealed an enlarged lymph node in the anterior cervical chains, confirming a diagnosis of Non-Hodgkin’s lymphoma. This case illustrates that it is important to have a high degree of suspicion in any patient presenting with unexplained enlarged kidneys without any identifiable cause because it could be the first presentation of a hematologic malignancy.
Literature
1.
go back to reference Seidemann K, Tiemann M, Schrappe M, Yakisan E, Simonitsch I, Janka-Schaub G, Dörffel W, Zimmermann M, Mann G, Gadner H, Parwaresch R, Riehm H, Reiter A (2001) Short-pulse B-non-Hodgkin lymphoma-type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the berlin-Frankfurt-Münster group trial NHL-BFM 90. Blood 97:3699–3706CrossRefPubMed Seidemann K, Tiemann M, Schrappe M, Yakisan E, Simonitsch I, Janka-Schaub G, Dörffel W, Zimmermann M, Mann G, Gadner H, Parwaresch R, Riehm H, Reiter A (2001) Short-pulse B-non-Hodgkin lymphoma-type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the berlin-Frankfurt-Münster group trial NHL-BFM 90. Blood 97:3699–3706CrossRefPubMed
2.
go back to reference Buyukpamukcu M, Varan A, Aydin B, Kale G, Akata D, Yalçin B, Akyuz C, Kutluk T (2005) Renal involvement of non-Hodgkin’s lymphoma and its prognostic effect in childhood. Nephron Clin Pract 100:86–91CrossRef Buyukpamukcu M, Varan A, Aydin B, Kale G, Akata D, Yalçin B, Akyuz C, Kutluk T (2005) Renal involvement of non-Hodgkin’s lymphoma and its prognostic effect in childhood. Nephron Clin Pract 100:86–91CrossRef
3.
go back to reference Truong LD, Soroka S, Sheth AV, Kessler M, Mattioli C, Suki W (1987) Primary renal lymphoma presenting as acute renal failure. Am J Kidney Dis 9:502–506CrossRefPubMed Truong LD, Soroka S, Sheth AV, Kessler M, Mattioli C, Suki W (1987) Primary renal lymphoma presenting as acute renal failure. Am J Kidney Dis 9:502–506CrossRefPubMed
4.
go back to reference Ferry JA, Harris NL, Papanicolaou N, Young RH (1995) Lymphoma of the kidney: a report of 11 cases. Am J Surg Pathol 19:134–144CrossRefPubMed Ferry JA, Harris NL, Papanicolaou N, Young RH (1995) Lymphoma of the kidney: a report of 11 cases. Am J Surg Pathol 19:134–144CrossRefPubMed
5.
go back to reference Brouland JP, Meeus F, Rossert J, Hernigou A, Gentric D, Jacquot C, Diebold J, Nochy D (1994) Primary bilateral B-cell renal lymphoma: a case report and review of the literature. Am J Kidney Dis 24:586–589CrossRefPubMed Brouland JP, Meeus F, Rossert J, Hernigou A, Gentric D, Jacquot C, Diebold J, Nochy D (1994) Primary bilateral B-cell renal lymphoma: a case report and review of the literature. Am J Kidney Dis 24:586–589CrossRefPubMed
6.
go back to reference Malbrain ML, Lambrecht GL, Daelemans R, Lins RL, Hermans P, Zachée P (1994) Acute renal failure due to bilateral lymphomatous infiltrates. Primary extranodal non-Hodgkin’s lymphoma (p-EN-NHL) of the kidneys: does it really exist? Clin Nephrol 42:163–169PubMed Malbrain ML, Lambrecht GL, Daelemans R, Lins RL, Hermans P, Zachée P (1994) Acute renal failure due to bilateral lymphomatous infiltrates. Primary extranodal non-Hodgkin’s lymphoma (p-EN-NHL) of the kidneys: does it really exist? Clin Nephrol 42:163–169PubMed
7.
go back to reference Kiely JM, Wagoner RD, Holley KE (1969) Renal complications of lymphoma. Ann Intern Med 71:1159–1175CrossRefPubMed Kiely JM, Wagoner RD, Holley KE (1969) Renal complications of lymphoma. Ann Intern Med 71:1159–1175CrossRefPubMed
8.
go back to reference Da’as N, Polliack A, Cohen Y, Amir G, Darmon D, Kleinman Y, Goldfarb AW, Ben-Yehuda D (2001) Kidney involvement and renal manifestations in non Hodgkin’s lymphoma and lymphocytic leukemia: a retrospective study in 700 patients. Eur J Haematol 67:158–164CrossRefPubMed Da’as N, Polliack A, Cohen Y, Amir G, Darmon D, Kleinman Y, Goldfarb AW, Ben-Yehuda D (2001) Kidney involvement and renal manifestations in non Hodgkin’s lymphoma and lymphocytic leukemia: a retrospective study in 700 patients. Eur J Haematol 67:158–164CrossRefPubMed
9.
go back to reference Lewi HJE, Stewart ID, Seywright M, Fleming S, Deane RF, Kyle KF (1986) Urinary tract lymphoma. Br J Urol 58:16–18CrossRefPubMed Lewi HJE, Stewart ID, Seywright M, Fleming S, Deane RF, Kyle KF (1986) Urinary tract lymphoma. Br J Urol 58:16–18CrossRefPubMed
10.
go back to reference Richmond J, Sherman RS, Diamond HD, Craver LF (1962) Renal lesions associated with malignant lymphomas. Am J Med 32:184–207CrossRefPubMed Richmond J, Sherman RS, Diamond HD, Craver LF (1962) Renal lesions associated with malignant lymphomas. Am J Med 32:184–207CrossRefPubMed
11.
go back to reference Cohen LJ, Rennke HG, Laubach JP, Humphreys BD (2010) The spectrum of kidney involvement in lymphoma: a case report and review of the literature. Am J Kidney Dis 56:1191–1196CrossRefPubMedPubMedCentral Cohen LJ, Rennke HG, Laubach JP, Humphreys BD (2010) The spectrum of kidney involvement in lymphoma: a case report and review of the literature. Am J Kidney Dis 56:1191–1196CrossRefPubMedPubMedCentral
12.
go back to reference Rault R, Holley JL, Banner BF, el-Shahawy M (1992) Glomerulonephritis and non-Hodgkin’s lymphoma: a report of two cases and review of the literature. Am J Kidney Dis 20:84–89CrossRefPubMed Rault R, Holley JL, Banner BF, el-Shahawy M (1992) Glomerulonephritis and non-Hodgkin’s lymphoma: a report of two cases and review of the literature. Am J Kidney Dis 20:84–89CrossRefPubMed
13.
go back to reference Stokes MB, Wood B, Alpers CE (2002) Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin Nephrol 57:303–309CrossRefPubMed Stokes MB, Wood B, Alpers CE (2002) Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin Nephrol 57:303–309CrossRefPubMed
14.
go back to reference Miyake JS, Fitterer S, Houghton DC (1990) Diagnosis and characterization of non-Hodgkin’s lymphoma in a patient with acute renal failure. Am J Kidney Dis 16:262–263CrossRefPubMed Miyake JS, Fitterer S, Houghton DC (1990) Diagnosis and characterization of non-Hodgkin’s lymphoma in a patient with acute renal failure. Am J Kidney Dis 16:262–263CrossRefPubMed
15.
go back to reference Ellman L, Davis J, Lichtenstein NS (1974) Uremia due to occult lymphomatous infiltration of the kidneys. Cancer 33:203–205CrossRefPubMed Ellman L, Davis J, Lichtenstein NS (1974) Uremia due to occult lymphomatous infiltration of the kidneys. Cancer 33:203–205CrossRefPubMed
16.
go back to reference Kowalewska J, Nicosia RF, Smith KD, Kats A, Alpers CE (2011) Patterns of glomerular injury in kidneys infiltrated by lymphoplasmacytic neoplasms. Hum Pathol 42:896–903CrossRefPubMed Kowalewska J, Nicosia RF, Smith KD, Kats A, Alpers CE (2011) Patterns of glomerular injury in kidneys infiltrated by lymphoplasmacytic neoplasms. Hum Pathol 42:896–903CrossRefPubMed
17.
go back to reference Shi SF, Zhou FD, Zou WZ, Wang HY (2012) Acute kidney injury and bilateral symmetrical enlargement of the kidneys as first presentation of B-cell lymphoblastic lymphoma. Am J Kidney Dis 60:1044–1048CrossRefPubMed Shi SF, Zhou FD, Zou WZ, Wang HY (2012) Acute kidney injury and bilateral symmetrical enlargement of the kidneys as first presentation of B-cell lymphoblastic lymphoma. Am J Kidney Dis 60:1044–1048CrossRefPubMed
18.
go back to reference Yeo SC, Chuah KL, Lee HY, Liew A (2013) An unusual case of glomerulonephritis in a patient with non-Hodgkin mucosal associated lymphoid tissue (MALT) B-cell lymphoma. BMC Nephrol 14:158CrossRefPubMedPubMedCentral Yeo SC, Chuah KL, Lee HY, Liew A (2013) An unusual case of glomerulonephritis in a patient with non-Hodgkin mucosal associated lymphoid tissue (MALT) B-cell lymphoma. BMC Nephrol 14:158CrossRefPubMedPubMedCentral
19.
go back to reference Ng YY, Healy JC, Vincent JM, Kingston JE, Armstrong P, Reznek RH (1994) The radiology of non-Hodgkin’s lymphoma in childhood: a review of 80 cases. Clin Radiol 49:594–600CrossRefPubMed Ng YY, Healy JC, Vincent JM, Kingston JE, Armstrong P, Reznek RH (1994) The radiology of non-Hodgkin’s lymphoma in childhood: a review of 80 cases. Clin Radiol 49:594–600CrossRefPubMed
20.
go back to reference Mora J, Filippa DA, Thaler HT, Polyak T, Cranor ML, Wollner N (2000) Large cell non-Hodgkin lymphoma of childhood: analysis of 78 consecutive patients enrolled in 2 consecutive protocols at the memorial Sloan Kettering Cancer center. Cancer 88:186–197CrossRefPubMed Mora J, Filippa DA, Thaler HT, Polyak T, Cranor ML, Wollner N (2000) Large cell non-Hodgkin lymphoma of childhood: analysis of 78 consecutive patients enrolled in 2 consecutive protocols at the memorial Sloan Kettering Cancer center. Cancer 88:186–197CrossRefPubMed
21.
go back to reference Attard-Montalto SP, Saha V, Norton AJ, Kingston JE, Eden OB (1993) Anaplastic large cell lymphoma in childhood. Med Pediatr Oncol 21:665–669CrossRefPubMed Attard-Montalto SP, Saha V, Norton AJ, Kingston JE, Eden OB (1993) Anaplastic large cell lymphoma in childhood. Med Pediatr Oncol 21:665–669CrossRefPubMed
22.
go back to reference Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 84:1361PubMed Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 84:1361PubMed
23.
go back to reference Falini B, Pileri S, Zinzani PL, Carbone A, Zagonel V, Wolf-Peeters C, Verhoef G, Menestrina F, Todeschini G, Paulli M, Lazzarino M, Giardini R, Aiello A, Foss HD, Araujo I, Fizzotti M, Pelicci PG, Flenghi L, Martelli MF, Santucci A (1999) ALK1 lymphoma: clinico-pathological findings and outcome. Blood 93:2697PubMed Falini B, Pileri S, Zinzani PL, Carbone A, Zagonel V, Wolf-Peeters C, Verhoef G, Menestrina F, Todeschini G, Paulli M, Lazzarino M, Giardini R, Aiello A, Foss HD, Araujo I, Fizzotti M, Pelicci PG, Flenghi L, Martelli MF, Santucci A (1999) ALK1 lymphoma: clinico-pathological findings and outcome. Blood 93:2697PubMed
24.
go back to reference Filippa DA, Ladanyi M, Wollner N, Straus DJ, O’Brien JP, Portlock C, Gangi M, Sun M (1996) CD30 (Ki-1)-positive malignant lymphomas: clinical, immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin’s disease. Blood 87:2905PubMed Filippa DA, Ladanyi M, Wollner N, Straus DJ, O’Brien JP, Portlock C, Gangi M, Sun M (1996) CD30 (Ki-1)-positive malignant lymphomas: clinical, immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin’s disease. Blood 87:2905PubMed
Metadata
Title
Abdominal pain in a 5-year-old girl with bilateral nephromegaly: Answers
Authors
Hulya Nalcacioglu
Sibel Yel
Meriban Karadogan
Fatma Turkan Mutlu
Funda Bastug
Yasemin Altuner Torun
Publication date
01-03-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 3/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3696-2

Other articles of this Issue 3/2018

Pediatric Nephrology 3/2018 Go to the issue