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Pediatric Nephrology
Published in: Pediatric Nephrology 3/2017

01-03-2017 | Review

Prorenin receptor in kidney development

Author: Ihor V. Yosypiv

Published in: Pediatric Nephrology | Issue 3/2017

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Abstract

Prorenin receptor (PRR), a receptor for renin and prorenin and an accessory subunit of the vacuolar proton pump H+-ATPase, is expressed in the developing kidney. Global loss of PRR is lethal in mice, and PRR mutations are associated with a high blood pressure, left ventricular hypertrophy and X-linked mental retardation in humans. With the advent of modern gene targeting techniques, including conditional knockout approaches, several recent studies have demonstrated critical roles for the PRR in several lineages of the developing kidney. PRR signaling has been shown to be essential for branching morphogenesis of the ureteric bud (UB), nephron progenitor survival and nephrogenesis. PRR regulates these developmental events through interactions with other transcription and growth factors. Several targeted PRR knockout animal models have structural defects mimicking congenital anomalies of the kidney and urinary tract observed in humans. The aim of this review, is to highlight new insights into the cellular and molecular mechanisms by which PRR may regulate UB branching, terminal differentiation and function of UB-derived collecting ducts, nephron progenitor maintenance, progression of nephrogenesis and normal structural kidney development and function.
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Metadata
Title
Prorenin receptor in kidney development
Author
Ihor V. Yosypiv
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 3/2017
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-016-3365-x

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