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01-08-2016 | Original Article

Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study

Authors: Aymeric Cantais, Zeineb Hammouda, Olivier Mory, Hugues Patural, Jean-Louis Stephan, Lyudmyla Gulyaeva, Michael Darmon

Published in: Pediatric Nephrology | Issue 8/2016

Abstract

Background

Contrast-induced acute kidney injury (CI-AKI) is a common pathology among adult patients, with an incidence ranging from 3–25 % depending on risk factors. Little information is available regarding CI-AKI incidence, risk factors, and prognostic impact in the pediatric population.

Methods

We performed a retrospective study of pediatric patients who underwent computed tomography (CT) scan with iodinated contrast media injection between 2005 and 2014 in five pediatric units of a university hospital. CI-AKI was defined according to Kidney Disease/Improving Global Outcomes (KDIGO) criteria.

Results

Of 346 identified patients, 233 had renal function follow-up and were included in our analyses. CI-AKI incidence was 10.3 % [95 % confidence interval (CI) 6.4–14.2 %]. CI-AKI was associated with 30-day unfavorable outcome before (45.8 % vs. 19.7 %, P = 0.007) and after [odds ratio (OR) 3.6; 95 % CI 1.4–9.5] adjustment for confounders. No independent risk factors of CI-AKI were identified.

Conclusions

CI-AKI incidence was as high as 10.3 % following intravenous contrast media administration in the pediatric setting. As reported among adults, CI-AKI was associated with unfavorable outcome after adjustment for confounders. Although additional studies are needed in the pediatric setting, our data suggest that physicians should maintain a high degree of suspicion toward this complication among pediatric patients.

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Title: Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study
Authors: Aymeric Cantais
Zeineb Hammouda
Olivier Mory
Hugues Patural
Jean-Louis Stephan
Lyudmyla Gulyaeva
Michael Darmon
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3313-9

At a glance: The STEP trials

Springer Medicine

Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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