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Pediatric Nephrology
Published in: Pediatric Nephrology 8/2016

01-08-2016 | Original Article

Oxidative stress and cardiac dysfunction in children with chronic renal failure on regular hemodialysis

Authors: Mohammed Al-Biltagi, Osama A. Tolba, Maher Ahmed Abd ElHafez, Ahmed Abd ElBasset Abo-Elezz, Eman Kamel EL Kady, Sahar Mohey El-din Hazza

Published in: Pediatric Nephrology | Issue 8/2016

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Abstract

Objective

The objective of this study was to evaluate cardiac function in children with end-stage renal disease (ESRD) on regular hemodialysis using speckle tracking echocardiography (STE) and correlate results with plasma glutathione level as a marker of oxidative stress.

Methods

The study involved 30 children with ESRD and 30 healthy controls. The plasma glutathione and C-reactive protein (CRP) levels were measured, and cardiac function was evaluated using conventional echocardiography and STE.

Results

Plasma glutathione levels were significantly lower and CRP significantly higher in patients than in controls. Children with ESRD had significant systolic and diastolic cardiac dysfunctions detected by STE compared with controls. Conventional echocardiography failed to detect these dysfunctions. There was significant increase in left-ventricular relative wall thickness (LV-RWT) in patients, especially those with hypertension, compared with the control group. There was also significant impairment of LV and right-ventricular (RV) global longitudinal strain (GLS) and torsion; however, LV-GLS was significantly better in hypertensive than in normotensive patients. The degree of impairment in GLS and cardiac torsion negatively correlated with plasma glutathione levels.

Conclusion

Significant oxidative stress was present in children with ESRD and was correlated with the degree of cardiac dysfunction detected early using the new cardiac imaging modality, STE.
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Metadata
Title
Oxidative stress and cardiac dysfunction in children with chronic renal failure on regular hemodialysis
Authors
Mohammed Al-Biltagi
Osama A. Tolba
Maher Ahmed Abd ElHafez
Ahmed Abd ElBasset Abo-Elezz
Eman Kamel EL Kady
Sahar Mohey El-din Hazza
Publication date
01-08-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 8/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-016-3314-8

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