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Published in: Pediatric Nephrology 9/2014

01-09-2014 | Original Article

Kidney size and function in a multi-ethnic population-based cohort of school-age children

Authors: Hanneke Bakker, Marjolein N. Kooijman, Albert J. van der Heijden, Albert Hofman, Oscar H. Franco, H. Rob Taal, Vincent W. V. Jaddoe

Published in: Pediatric Nephrology | Issue 9/2014

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Abstract

Background

Subclinical impaired kidney growth and function in childhood may lead to kidney diseases and high blood pressure in adulthood. We assessed the cross-sectional associations of childhood characteristics with kidney size and function in a multi-ethnic cohort.

Methods

This study was embedded in a population-based cohort study of 6,397 children with a median age of 6.0 years.Kidney volume, creatinine and cystatin C blood levels, microalbuminuria and blood pressure were measured, and glomerular filtration rate (GFR) was estimated.

Results

Childhood anthropometrics were positively associated with kidney volume, creatinine level and blood pressure (all p < 0.05). We observed ethnic differences in all kidney size and function measures (all p < 0.05). Children with smaller kidneys had higher creatinine and cystatin C blood levels, leading to a lower estimated GFR [difference 5.68 ml/min/1.73 m2 (95 % confidence interval 5.14–6.12) per 1 standard deviation increase in kidney volume]. Larger kidney volume was associated with an increased risk of microalbuminuria.

Conclusions

Childhood kidney volume and function are influenced by body mass index and ethnicity. Kidney volume is related with kidney function but not with blood pressure. These results may help to identify individuals at risk for kidney disease in an early stage.
Appendix
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Literature
1.
go back to reference Singh GR, Hoy WE (2004) Kidney volume, blood pressure, and albuminuria: findings in an Australian aboriginal community. Am J Kidney Dis 43:254–259PubMedCrossRef Singh GR, Hoy WE (2004) Kidney volume, blood pressure, and albuminuria: findings in an Australian aboriginal community. Am J Kidney Dis 43:254–259PubMedCrossRef
2.
go back to reference White SL, Perkovic V, Cass A, Chang CL, Poulter NR, Spector T, Haysom L, Craig JC, Salmi IA, Chadban SJ, Huxley RR (2009) Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis 54:248–261PubMedCrossRef White SL, Perkovic V, Cass A, Chang CL, Poulter NR, Spector T, Haysom L, Craig JC, Salmi IA, Chadban SJ, Huxley RR (2009) Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis 54:248–261PubMedCrossRef
3.
go back to reference Luyckx VA, Brenner BM (2010) The clinical importance of nephron mass. J Am Soc Nephrol 21:898–910PubMedCrossRef Luyckx VA, Brenner BM (2010) The clinical importance of nephron mass. J Am Soc Nephrol 21:898–910PubMedCrossRef
4.
go back to reference Brenner BM, Chertow GM (1994) Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury. Am J Kidney Dis 23:171–175PubMedCrossRef Brenner BM, Chertow GM (1994) Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury. Am J Kidney Dis 23:171–175PubMedCrossRef
5.
go back to reference Chen X, Wang Y (2008) Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 117:3171–3180PubMedCentralPubMedCrossRef Chen X, Wang Y (2008) Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 117:3171–3180PubMedCentralPubMedCrossRef
7.
go back to reference Cignarelli M, Lamacchia O (2007) Obesity and kidney disease. Nutr Metab Cardiovasc Dis 17:757–762PubMedCrossRef Cignarelli M, Lamacchia O (2007) Obesity and kidney disease. Nutr Metab Cardiovasc Dis 17:757–762PubMedCrossRef
8.
go back to reference Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A (2012) The Generation R Study: design and cohort update 2012. Eur J Epidemiol 27:739–756PubMedCrossRef Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A (2012) The Generation R Study: design and cohort update 2012. Eur J Epidemiol 27:739–756PubMedCrossRef
9.
go back to reference Statistics Netherlands (2003) Migrants in the Netherlands, 2003. Statistics Netherlands, The Hague Statistics Netherlands (2003) Migrants in the Netherlands, 2003. Statistics Netherlands, The Hague
10.
go back to reference Jaddoe VW, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Verhulst FC, Witteman JC, Hofman A (2006) The Generation R Study: design and cohort profile. Eur J Epidemiol 21:475–484PubMedCrossRef Jaddoe VW, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Verhulst FC, Witteman JC, Hofman A (2006) The Generation R Study: design and cohort profile. Eur J Epidemiol 21:475–484PubMedCrossRef
11.
go back to reference Troe EJ, Raat H, Jaddoe VW, Hofman A, Looman CW, Moll HA, Steegers EA, Verhulst FC, Witteman JC, Mackenbach JP (2007) Explaining differences in birthweight between ethnic populations. The Generation R Study. BJOG 114:1557–1565PubMedCrossRef Troe EJ, Raat H, Jaddoe VW, Hofman A, Looman CW, Moll HA, Steegers EA, Verhulst FC, Witteman JC, Mackenbach JP (2007) Explaining differences in birthweight between ethnic populations. The Generation R Study. BJOG 114:1557–1565PubMedCrossRef
12.
go back to reference Geelhoed JJ, Taal HR, Steegers EA, Arends LR, Lequin M, Moll HA, Hofman A, van der Heijden AJ, Jaddoe VW (2010) Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Pediatr Nephrol 25:289–298PubMedCrossRef Geelhoed JJ, Taal HR, Steegers EA, Arends LR, Lequin M, Moll HA, Hofman A, van der Heijden AJ, Jaddoe VW (2010) Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Pediatr Nephrol 25:289–298PubMedCrossRef
13.
go back to reference Geelhoed JJ, Kleyburg-Linkers VE, Snijders SP, Lequin M, Nauta J, Steegers EA, van der Heijden AJ, Jaddoe VW (2009) Reliability of renal ultrasound measurements in children. Pediatr Nephrol 24:1345–1353PubMedCrossRef Geelhoed JJ, Kleyburg-Linkers VE, Snijders SP, Lequin M, Nauta J, Steegers EA, van der Heijden AJ, Jaddoe VW (2009) Reliability of renal ultrasound measurements in children. Pediatr Nephrol 24:1345–1353PubMedCrossRef
14.
go back to reference Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637PubMedCentralPubMedCrossRef Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637PubMedCentralPubMedCrossRef
15.
go back to reference Donaghue KC, Chiarelli F, Trotta D, Allgrove J, Dahl-Jorgensen K; International Society for P, Adolescent D (2007) ISPAD Clinical Practice Consensus Guidelines 2006–2007. Microvascular and macrovascular complications. Pediatr Diabetes 8:163-170 Donaghue KC, Chiarelli F, Trotta D, Allgrove J, Dahl-Jorgensen K; International Society for P, Adolescent D (2007) ISPAD Clinical Practice Consensus Guidelines 2006–2007. Microvascular and macrovascular complications. Pediatr Diabetes 8:163-170
16.
go back to reference Wong SN, Tz Sung RY, Leung LC (2006) Validation of three oscillometric blood pressure devices against auscultatory mercury sphygmomanometer in children. Blood Press Monit 11:281–291PubMedCrossRef Wong SN, Tz Sung RY, Leung LC (2006) Validation of three oscillometric blood pressure devices against auscultatory mercury sphygmomanometer in children. Blood Press Monit 11:281–291PubMedCrossRef
17.
go back to reference Bacchetta J, Cochat P, Rognant N, Ranchin B, Hadj-Aissa A, Dubourg L (2011) Which creatinine and cystatin C equations can be reliably used in children? Clin J Am Soc Nephrol 6:552–560PubMedCentralPubMedCrossRef Bacchetta J, Cochat P, Rognant N, Ranchin B, Hadj-Aissa A, Dubourg L (2011) Which creatinine and cystatin C equations can be reliably used in children? Clin J Am Soc Nephrol 6:552–560PubMedCentralPubMedCrossRef
18.
19.
go back to reference Lawlor DA, Najman JM, Sterne J, Williams GM, Ebrahim S, Davey Smith G (2004) Associations of parental, birth, and early life characteristics with systolic blood pressure at 5 years of age: findings from the Mater-University study of pregnancy and its outcomes. Circulation 110:2417–2423PubMedCrossRef Lawlor DA, Najman JM, Sterne J, Williams GM, Ebrahim S, Davey Smith G (2004) Associations of parental, birth, and early life characteristics with systolic blood pressure at 5 years of age: findings from the Mater-University study of pregnancy and its outcomes. Circulation 110:2417–2423PubMedCrossRef
20.
go back to reference Bakker J, Olree M, Kaatee R, de Lange EE, Moons KG, Beutler JJ, Beek FJ (1999) Renal volume measurements: accuracy and repeatability of US compared with that of MR imaging. Radiology 211:623–628PubMedCrossRef Bakker J, Olree M, Kaatee R, de Lange EE, Moons KG, Beutler JJ, Beek FJ (1999) Renal volume measurements: accuracy and repeatability of US compared with that of MR imaging. Radiology 211:623–628PubMedCrossRef
21.
go back to reference Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348:101–108PubMedCrossRef Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348:101–108PubMedCrossRef
22.
go back to reference Ingelfinger JR, Nuyt AM (2012) Impact of fetal programming, birth weight, and infant feeding on later hypertension. J Clin Hypertens (Greenwich) 14:365–371CrossRef Ingelfinger JR, Nuyt AM (2012) Impact of fetal programming, birth weight, and infant feeding on later hypertension. J Clin Hypertens (Greenwich) 14:365–371CrossRef
23.
go back to reference Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D (1991) Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest 64:777–784PubMed Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D (1991) Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest 64:777–784PubMed
24.
go back to reference Manalich R, Reyes L, Herrera M, Melendi C, Fundora I (2000) Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 58:770–773PubMedCrossRef Manalich R, Reyes L, Herrera M, Melendi C, Fundora I (2000) Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 58:770–773PubMedCrossRef
25.
go back to reference Zhang Z, Quinlan J, Hoy W, Hughson MD, Lemire M, Hudson T, Hueber PA, Benjamin A, Roy A, Pascuet E, Goodyer M, Raju C, Houghton F, Bertram J, Goodyer P (2008) A common RET variant is associated with reduced newborn kidney size and function. J Am Soc Nephrol 19:2027–2034PubMedCentralPubMedCrossRef Zhang Z, Quinlan J, Hoy W, Hughson MD, Lemire M, Hudson T, Hueber PA, Benjamin A, Roy A, Pascuet E, Goodyer M, Raju C, Houghton F, Bertram J, Goodyer P (2008) A common RET variant is associated with reduced newborn kidney size and function. J Am Soc Nephrol 19:2027–2034PubMedCentralPubMedCrossRef
26.
go back to reference Hoy WE, Bertram JF, Denton RD, Zimanyi M, Samuel T, Hughson MD (2008) Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 17:258–265PubMedCrossRef Hoy WE, Bertram JF, Denton RD, Zimanyi M, Samuel T, Hughson MD (2008) Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 17:258–265PubMedCrossRef
27.
go back to reference Stevens LA, Coresh J, Greene T, Levey AS (2006) Assessing kidney function–measured and estimated glomerular filtration rate. N Engl J Med 354:2473–2483PubMedCrossRef Stevens LA, Coresh J, Greene T, Levey AS (2006) Assessing kidney function–measured and estimated glomerular filtration rate. N Engl J Med 354:2473–2483PubMedCrossRef
28.
go back to reference Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A (2005) Cystatin C as a marker of GFR—history, indications, and future research. Clin Biochem 38:1–8PubMedCrossRef Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A (2005) Cystatin C as a marker of GFR—history, indications, and future research. Clin Biochem 38:1–8PubMedCrossRef
29.
go back to reference Groesbeck D, Kottgen A, Parekh R, Selvin E, Schwartz GJ, Coresh J, Furth S (2008) Age, gender, and race effects on cystatin C levels in US adolescents. Clin J Am Soc Nephrol 3:1777–1785PubMedCentralPubMedCrossRef Groesbeck D, Kottgen A, Parekh R, Selvin E, Schwartz GJ, Coresh J, Furth S (2008) Age, gender, and race effects on cystatin C levels in US adolescents. Clin J Am Soc Nephrol 3:1777–1785PubMedCentralPubMedCrossRef
30.
go back to reference Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS, Investigators C-E (2012) Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367:20–29PubMedCrossRef Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS, Investigators C-E (2012) Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367:20–29PubMedCrossRef
31.
go back to reference Cha RH, Lee CS, Lim YH, Kim H, Lee SH, Yu KS, Kim YS (2010) Clinical usefulness of serum cystatin C and the pertinent estimation of glomerular filtration rate based on cystatin C. Nephrol (Carlton) 15:768–776CrossRef Cha RH, Lee CS, Lim YH, Kim H, Lee SH, Yu KS, Kim YS (2010) Clinical usefulness of serum cystatin C and the pertinent estimation of glomerular filtration rate based on cystatin C. Nephrol (Carlton) 15:768–776CrossRef
32.
go back to reference Fadrowski JJ, Neu AM, Schwartz GJ, Furth SL (2011) Pediatric GFR estimating equations applied to adolescents in the general population. Clin J Am Soc Nephrol 6:1427–1435 Fadrowski JJ, Neu AM, Schwartz GJ, Furth SL (2011) Pediatric GFR estimating equations applied to adolescents in the general population. Clin J Am Soc Nephrol 6:1427–1435
33.
go back to reference de Jong PE, Curhan GC (2006) Screening, monitoring, and treatment of albuminuria: Public health perspectives. J Am Soc Nephrol 17:2120–2126PubMedCrossRef de Jong PE, Curhan GC (2006) Screening, monitoring, and treatment of albuminuria: Public health perspectives. J Am Soc Nephrol 17:2120–2126PubMedCrossRef
34.
go back to reference Miller WG, Bruns DE, Hortin GL, Sandberg S, Aakre KM, McQueen MJ, Itoh Y, Lieske JC, Seccombe DW, Jones G, Bunk DM, Curhan GC, Narva AS, and on behalf of the National Kidney Disease Education Program–IFCC Working Group on Standardization of Albumin in Urine (2009) Current issues in measurement and reporting of urinary albumin excretion. Clin Chem 55:24–38 Miller WG, Bruns DE, Hortin GL, Sandberg S, Aakre KM, McQueen MJ, Itoh Y, Lieske JC, Seccombe DW, Jones G, Bunk DM, Curhan GC, Narva AS, and on behalf of the National Kidney Disease Education Program–IFCC Working Group on Standardization of Albumin in Urine (2009) Current issues in measurement and reporting of urinary albumin excretion. Clin Chem 55:24–38
35.
go back to reference Myers MG, McInnis NH, Fodor GJ, Leenen FH (2008) Comparison between an automated and manual sphygmomanometer in a population survey. Am J Hypertens 21:280–283PubMedCrossRef Myers MG, McInnis NH, Fodor GJ, Leenen FH (2008) Comparison between an automated and manual sphygmomanometer in a population survey. Am J Hypertens 21:280–283PubMedCrossRef
36.
go back to reference Nguyen S, Hsu CY (2007) Excess weight as a risk factor for kidney failure. Curr Opin Nephrol Hypertens 16:71–76PubMedCrossRef Nguyen S, Hsu CY (2007) Excess weight as a risk factor for kidney failure. Curr Opin Nephrol Hypertens 16:71–76PubMedCrossRef
37.
go back to reference Lawlor DA, Benfield L, Logue J, Tilling K, Howe LD, Fraser A, Cherry L, Watt P, Ness AR, Davey Smith G, Sattar N (2010) Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort study. BMJ 341:c6224PubMedCentralPubMedCrossRef Lawlor DA, Benfield L, Logue J, Tilling K, Howe LD, Fraser A, Cherry L, Watt P, Ness AR, Davey Smith G, Sattar N (2010) Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort study. BMJ 341:c6224PubMedCentralPubMedCrossRef
38.
go back to reference Paradis G, Lambert M, O'Loughlin J, Lavallee C, Aubin J, Delvin E, Levy E, Hanley JA (2004) Blood pressure and adiposity in children and adolescents. Circulation 110:1832–1838PubMedCrossRef Paradis G, Lambert M, O'Loughlin J, Lavallee C, Aubin J, Delvin E, Levy E, Hanley JA (2004) Blood pressure and adiposity in children and adolescents. Circulation 110:1832–1838PubMedCrossRef
39.
go back to reference Savino A, Pelliccia P, Giannini C, de Giorgis T, Cataldo I, Chiarelli F, Mohn A (2011) Implications for kidney disease in obese children and adolescents. Pediatr Nephrol 26:749–758PubMedCrossRef Savino A, Pelliccia P, Giannini C, de Giorgis T, Cataldo I, Chiarelli F, Mohn A (2011) Implications for kidney disease in obese children and adolescents. Pediatr Nephrol 26:749–758PubMedCrossRef
40.
go back to reference Kramer H, Palmas W, Kestenbaum B, Cushman M, Allison M, Astor B, Shlipak M (2008) Chronic kidney disease prevalence estimates among racial/ethnic groups: the Multi-Ethnic Study of Atherosclerosis. Clin J Am Soc Nephrol 3:1391–1397PubMedCentralPubMedCrossRef Kramer H, Palmas W, Kestenbaum B, Cushman M, Allison M, Astor B, Shlipak M (2008) Chronic kidney disease prevalence estimates among racial/ethnic groups: the Multi-Ethnic Study of Atherosclerosis. Clin J Am Soc Nephrol 3:1391–1397PubMedCentralPubMedCrossRef
41.
go back to reference van den Born BJ, Koopmans RP, Groeneveld JO, van Montfrans GA (2006) Ethnic disparities in the incidence, presentation and complications of malignant hypertension. J Hypertens 24:2299–2304PubMedCrossRef van den Born BJ, Koopmans RP, Groeneveld JO, van Montfrans GA (2006) Ethnic disparities in the incidence, presentation and complications of malignant hypertension. J Hypertens 24:2299–2304PubMedCrossRef
42.
go back to reference Agyemang C, Ujcic-Voortman J, Uitenbroek D, Foets M, Droomers M (2006) Prevalence and management of hypertension among Turkish, Moroccan and native Dutch ethnic groups in Amsterdam, the Netherlands: The Amsterdam Health Monitor Survey. J Hypertens 24:2169–2176PubMedCrossRef Agyemang C, Ujcic-Voortman J, Uitenbroek D, Foets M, Droomers M (2006) Prevalence and management of hypertension among Turkish, Moroccan and native Dutch ethnic groups in Amsterdam, the Netherlands: The Amsterdam Health Monitor Survey. J Hypertens 24:2169–2176PubMedCrossRef
43.
go back to reference Muntner P, He J, Cutler JA, Wildman RP, Whelton PK (2004) Trends in blood pressure among children and adolescents. JAMA 291:2107–2113PubMedCrossRef Muntner P, He J, Cutler JA, Wildman RP, Whelton PK (2004) Trends in blood pressure among children and adolescents. JAMA 291:2107–2113PubMedCrossRef
44.
go back to reference Harding S, Whitrow M, Lenguerrand E, Maynard M, Teyhan A, Cruickshank JK, Der G (2010) Emergence of ethnic differences in blood pressure in adolescence: the determinants of adolescent social well-being and health study. Hypertension 55:1063–1069PubMedCrossRef Harding S, Whitrow M, Lenguerrand E, Maynard M, Teyhan A, Cruickshank JK, Der G (2010) Emergence of ethnic differences in blood pressure in adolescence: the determinants of adolescent social well-being and health study. Hypertension 55:1063–1069PubMedCrossRef
45.
go back to reference Trachtenberg F, Barregard L (2007) The effect of age, sex, and race on urinary markers of kidney damage in children. Am J Kidney Dis 50:938–945PubMedCrossRef Trachtenberg F, Barregard L (2007) The effect of age, sex, and race on urinary markers of kidney damage in children. Am J Kidney Dis 50:938–945PubMedCrossRef
46.
go back to reference Olden M, Teumer A, Bochud M, Pattaro C, Kottgen A, Turner ST, Rettig R, Chen MH, Dehghan A, Bastardot F, Schmidt R, Vollenweider P, Schunkert H, Reilly MP, Fornage M, Launer LJ, Verwoert GC, Mitchell GF, Bis JC, O'Donnell CJ, Cheng CY, Sim X, Siscovick DS, Coresh J, Kao WH, Fox CS, O'Seaghdha CM, AortaGen CCECIMTIN, Consortia CK (2013) Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen Consortium. Am J Kidney Dis 61:889–898PubMedCentralPubMedCrossRef Olden M, Teumer A, Bochud M, Pattaro C, Kottgen A, Turner ST, Rettig R, Chen MH, Dehghan A, Bastardot F, Schmidt R, Vollenweider P, Schunkert H, Reilly MP, Fornage M, Launer LJ, Verwoert GC, Mitchell GF, Bis JC, O'Donnell CJ, Cheng CY, Sim X, Siscovick DS, Coresh J, Kao WH, Fox CS, O'Seaghdha CM, AortaGen CCECIMTIN, Consortia CK (2013) Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen Consortium. Am J Kidney Dis 61:889–898PubMedCentralPubMedCrossRef
47.
go back to reference Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tonjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Consortium CA, Consortium I, Consortium CA, Wellcome Trust Case Control C, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Doring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Kramer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS (2012) Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet 8:e1002584CrossRef Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tonjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Consortium CA, Consortium I, Consortium CA, Wellcome Trust Case Control C, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Doring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Kramer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS (2012) Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet 8:e1002584CrossRef
48.
go back to reference Di Zazzo G, Stringini G, Matteucci MC, Muraca M, Malena S, Emma F (2011) Serum creatinine levels are significantly influenced by renal size in the normal pediatric population. Clin J Am Soc Nephrol 6:107–113PubMedCentralPubMedCrossRef Di Zazzo G, Stringini G, Matteucci MC, Muraca M, Malena S, Emma F (2011) Serum creatinine levels are significantly influenced by renal size in the normal pediatric population. Clin J Am Soc Nephrol 6:107–113PubMedCentralPubMedCrossRef
49.
go back to reference Adibi A, Adibi I, Khosravi P (2007) Do kidney sizes in ultrasonography correlate to glomerular filtration rate in healthy children? Australas Radiol 51:555–559PubMedCrossRef Adibi A, Adibi I, Khosravi P (2007) Do kidney sizes in ultrasonography correlate to glomerular filtration rate in healthy children? Australas Radiol 51:555–559PubMedCrossRef
Metadata
Title
Kidney size and function in a multi-ethnic population-based cohort of school-age children
Authors
Hanneke Bakker
Marjolein N. Kooijman
Albert J. van der Heijden
Albert Hofman
Oscar H. Franco
H. Rob Taal
Vincent W. V. Jaddoe
Publication date
01-09-2014
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 9/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-014-2793-8

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