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01-12-2013 | Review

Role of mesenchymal stem cell-derived microvesicles in tissue repair

Authors: Stefania Bruno, Giovanni Camussi

Published in: Pediatric Nephrology | Issue 12/2013

Abstract

Results from recent studies suggest that the beneficial effect of stem cell-based therapy is mainly dependent on a paracrine effect. The paracrine hypothesis implicates the ability of stem cells to limit injury or coordinate repair through the release of soluble factors. Among these factors microvesicles (MVs) have emerged as a mechanism through which stem cells may reprogram injured cells. In fact, MVs released from stem cells may deliver proteins, bio-active lipids and nucleic acids to injured cells. In particular, the transfer of transcripts derived from stem cells may induce phenotypic and functional changes in the recipient cells that promote the activation of regenerative programs.

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Title: Role of mesenchymal stem cell-derived microvesicles in tissue repair
Authors: Stefania Bruno
Giovanni Camussi
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 12/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2413-z

At a glance: The STEP trials

Springer Medicine

Role of mesenchymal stem cell-derived microvesicles in tissue repair

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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