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01-12-2013 | Original Article

Birth parameters and parental height predict growth outcome in children with chronic kidney disease

Authors: Doris Franke, Hülya Alakan, Leo Pavičić, Jutta Gellermann, Dominik Müller, Uwe Querfeld, Dieter Haffner, Miroslav Živičnjak

Published in: Pediatric Nephrology | Issue 12/2013

Abstract

Background

We analyzed the impact of birth parameters and parental height on long-term growth outcome in children with chronic kidney disease (CKD) stage 3–5.

Methods

Linear growth was prospectively investigated in 509 children, with a mean follow-up of 4.1 years. Growth outcome was categorized in (i) poor growth (PG): height standard deviation score (SDS) during follow-up < −2.0 and/or actual or previous growth hormone (GH) treatment, and (ii) good growth (GG): height SDS ≥ −2.0 and no need for GH. A multivariate binary logistic regression model was constructed for predictors of PG outcome.

Results

PG was observed in 55 % of patients. The rate of pre-term and small for gestational age birth was significantly higher in children with PG compared to GG (43.2 vs. 25.6 % and 36.8 vs. 18.9 %; p < 0.001). Children with PG had significantly lower average values for gestational age, birth weight, length, and head circumference, umbilical cord pH, Apgar scores, and parental height than children with GG. Birth length, umbilical cord pH, and parental height were significant independent predictors of PG outcome (sensitivity 72.8 %, specificity 69.3 %).

Conclusions

Birth parameters and parental height are independent predictors of growth outcome in children with CKD.

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Title: Birth parameters and parental height predict growth outcome in children with chronic kidney disease
Authors: Doris Franke
Hülya Alakan
Leo Pavičić
Jutta Gellermann
Dominik Müller
Uwe Querfeld
Dieter Haffner
Miroslav Živičnjak
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 12/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2604-7

At a glance: The STEP trials

Springer Medicine

Birth parameters and parental height predict growth outcome in children with chronic kidney disease

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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