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01-07-2008 | Original Article

Long-term follow-up after cyclophosphamide and cyclosporine-A therapy in steroid-dependent and -resistant nephrotic syndrome

Authors: Viktória Sümegi, Ibolya Haszon, Csaba Bereczki, Ferenc Papp, Sándor Túri

Published in: Pediatric Nephrology | Issue 7/2008

Abstract

A retrospective study was made on 37 children with idiopathic nephrotic syndrome (INS). At the beginning, all patients were steroid sensitive but received more than one steroid course (median 4). Following several relapses, they became steroid dependent or steroid resistant. Group 1 consisted of 22 children [3 focal segmental glomerulosclerosis (FSGS), 19 minimal-change NS (MCNS)] who received cyclophosphamide (CP) orally for 2.5 ± 0.5 months. Group 2 consisted of 15 children (7 FSGS, 8 MCNS) who received cyclosporine-A (CSA) for 28 ± 15 months. The level of proteinuria decreased significantly and remained low during the follow-up. The relapse-free period was significantly longer in the CP group (CP 30 ± 21.5; CSA 26.2 ± 18 months, p < 0.001). The relapse rate decreased significantly in both groups and remained in this lower level during the follow-up (from 3.4 ± 2.8 to 0.1 ± 0.2/year in group 1, and from 3.7 ± 3.1 to 0.6 ± 0.8/year in group 2). At the end of the 5-year follow-up, 20/22 patients (90.9%) and 10/15 patients (66.6%) were in remission in groups 1 and 2 respectively, with or without treatment (p < 0.05). In the long term, both CP and CSA is effective second-line therapy following steroid monotherapy in INS patients, but the relapse rate was lower and the relapse free period was significantly longer in the CP-treated group.

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Title: Long-term follow-up after cyclophosphamide and cyclosporine-A therapy in steroid-dependent and -resistant nephrotic syndrome
Authors: Viktória Sümegi
Ibolya Haszon
Csaba Bereczki
Ferenc Papp
Sándor Túri
Publication date: 01-07-2008
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 7/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-008-0771-8

ACC 2024 Congress

Springer Medicine

Long-term follow-up after cyclophosphamide and cyclosporine-A therapy in steroid-dependent and -resistant nephrotic syndrome

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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