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Pediatric Nephrology
Published in: Pediatric Nephrology 12/2007

Open Access 01-12-2007 | Educational Feature

Mechanisms of progression of chronic kidney disease

Author: Agnes B. Fogo

Published in: Pediatric Nephrology | Issue 12/2007

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Abstract

Chronic kidney disease (CKD) occurs in all age groups, including children. Regardless of the underlying cause, CKD is characterized by progressive scarring that ultimately affects all structures of the kidney. The relentless progression of CKD is postulated to result from a self-perpetuating vicious cycle of fibrosis activated after initial injury. We will review possible mechanisms of progressive renal damage, including systemic and glomerular hypertension, various cytokines and growth factors, with special emphasis on the renin–angiotensin–aldosterone system (RAAS), podocyte loss, dyslipidemia and proteinuria. We will also discuss possible specific mechanisms of tubulointerstitial fibrosis that are not dependent on glomerulosclerosis, and possible underlying predispositions for CKD, such as genetic factors and low nephron number.
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Metadata
Title
Mechanisms of progression of chronic kidney disease
Author
Agnes B. Fogo
Publication date
01-12-2007
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 12/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-007-0524-0

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