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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2007

Open Access 01-10-2007 | Educational Feature

The central nervous system in childhood chronic kidney disease

Authors: Debbie S. Gipson, Peter J. Duquette, Phil F. Icard, Stephen R. Hooper

Published in: Pediatric Nephrology | Issue 10/2007

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Abstract

Neurodevelopmental deficits in pediatric and adult survivors of childhood onset chronic kidney disease (CKD) have been documented for many years. This paper reviews the available literature on central nervous system involvement incurred in childhood CKD. The studies reviewed include recent work in neuroimaging, electrophysiology, and neuropsychology, along with commentary on school functioning and long-term outcomes. The paper concludes with suggestions for monitoring the neurodevelopmental status and pursuing appropriate early interventions for children with CKD.
Literature
1.
Ferris ME, Gipson DS, Kimmel PL, Eggers PW (2006) Trends in treatment and outcomes of survival of adolescents initiating end-stage renal disease care in the United States of America. Pediatr Nephrol 21:1020–1026CrossRef
2.
Bock GH, Conners CK, Ruley J, Samango-Sprouse CA, Conry JA, Weiss I, Eng G, Johnson EL, David CT (1989) Disturbances of brain maturation and neurodevelopment during chronic renal failure in infancy. J Pediatr 114:231–238CrossRefPubMed
3.
Schnaper HW, Cole BR, Hodges FJ, Robson AM (1983) Cerebral cortical atrophy in pediatric patients with end-stage renal disease. Am J Kidney Dis 2:645–650CrossRefPubMed
4.
Elzouki A, Carroll J, Butinar D, Moosa A (1994) Improved neurological outcome in children with chronic renal disease from infancy. Pediatr Nephrol 8:205–210CrossRefPubMed
5.
Qvist E, Pihko H, Fagerudd P, Valanne L, Lamminranta S, Karikoski J, Sainio K, Ronnholm K, Jalanko H, Holmberg C (2002) Neurodevelopmental outcome in high-risk patients after renal transplantation in early childhood. Pediatr Transplant 6:53–62CrossRefPubMed
6.
Steinberg A, Efrat R, Pomeranz A, Drukker A (1985) Computerized tomography of the brain in children with chronic renal failure. Int J Pediatr Nephrol 6:121–126PubMed
7.
Valanne L, Qvist E, Jalanko H, Holmberg C, Pihko H (2004) Neuroradiologic findings in children with renal transplantation under 5 years of age. Pediatr Transplant 8:44–51CrossRefPubMed
8.
Nichols SL, Press GA, Schneider JA, Trauner DA (1990) Cortical atrophy and cognitive performance in infantile nephropathic cystinosis. Pediatr Neurol 6:379–381CrossRefPubMed
9.
Pueschel SM, Brem AS, Nittoli P (1992) Central nervous system and renal investigations in patients with Lowe syndrome. Childs Nerv Syst 8:45–48CrossRefPubMed
10.
Hurkx W, Hulstijn D, Pasman J, Rotteveel J, Visco Y, Schroder C (1995) Evoked potentials in children with chronic renal failure, treated conservatively or by continuous ambulatory peritoneal dialysis. Pediatr Nephrol 9:325–328CrossRefPubMed
11.
Teschan PE, Ginn HE, Bourne JR, Ward JW, Hamel B, Nunnally JC, Musso M, Vaughn WK (1979) Quantitative indices of clinical uremia. Kidney Int 15:676–697CrossRefPubMed
12.
Sagales T, Gimeno V, Planella MJ, Raguer N, Bartolome J (1993) Effects of rHuEPO on Q-EEG and event-related potentials in chronic renal failure. Kidney Int 44:1109–1115CrossRefPubMed
13.
Marsh JT, Brown WS, Wolcott D, Carr CR, Harper R, Schweitzer SV, Nissenson AR (1991) rHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int 39:155–163CrossRefPubMed
14.
Evers S, Tepel M, Obladen M, Suhr B, Husstedt IW, Grotemeyer KH, Zidek W (1998) Influence of end-stage renal failure and hemodialysis on event-related potentials. J Clin Neurophysiol 15:58–63CrossRefPubMed
15.
Tilki HE, Akpolat T, Tunali G, Kara A, Onar MK (2004) Effects of haemodialysis and continuous ambulatory peritoneal dialysis on P300 cognitive potentials in uraemic patients. Ups J Med Sci 109:43–48CrossRefPubMed
16.
Suppiej A, Casara G, Boniver C, Pozzan GB, Montini G, Zacchello G, Zacchello F (1991) Somatosensory pathway dysfunction in uremic children. Brain Dev 13:238–241CrossRefPubMed
17.
Warady BA, Fivush BA, Alexander SR (1999) Peritoneal dialysis. In: Barrat TM, Avner ED, Harmon WE eds. Pediatric nephrology, 4th edn. Lippincott Williams & Wilkins, Baltimore, pp 1251–1265
18.
19.
Polinsky MS, Kaiser BA, Stover JB (1987) Neurologic development of children with severe chronic renal failure from infancy. Pediatr Nephrol 1:157–165CrossRefPubMed
20.
Fennell RS, Fennell EB, Carter RL, Mings EL, Klausner AB, Hurst JR (1990) Correlations between performance on neuropsychological tests in children with chronic renal failure. Child Nephrol Urol 10:199–204PubMed
21.
Fennell RS, Fennell EB, Carter RL, Mings EL, Klausner AB, Hurst JR (1990) A longitudinal study of the cognitive function of children with renal failure. Pediatr Nephrol 4:11–15CrossRefPubMed
22.
Mendley SR, Zelko FA (1999) Improvement in specific aspects of neurocognitive performance in children after renal transplantation. Kidney Int 56:318–323CrossRefPubMed
23.
Brouhard BH, Donaldson LA, Lawry KW, McGowan KR, Drotar D, Davis I, Rose S, Cohn RA, Tejani A (2000) Cognitive functioning in children on dialysis and post-transplantation. Pediatr Transplant 4:261–267CrossRefPubMed
24.
Hulstijn-Dirkmaat GM, Damhuis IH, Jetten ML, Koster AM, Schroder CH (1995) The cognitive development of pre-school children treated for chronic renal failure. Pediatr Nephrol 9:464–469CrossRefPubMed
25.
Ledermann SE, Scanes ME, Fernando ON, Duffy PG, Madden SJ, Trompeter RS (2000) Long-term outcome of peritoneal dialysis in infants. J Pediatr 136:24–29CrossRefPubMed
26.
Warady BA, Belden B, Kohaut E (1999) Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy. Pediatr Nephrol 13:759–765CrossRefPubMed
27.
Madden SJ, Ledermann SE, Guerrero-Blanco M, Bruce M, Trompeter RS (2003) Cognitive and psychosocial outcome of infants dialysed in infancy. Child Care Health Dev 29:55–61CrossRefPubMed
28.
Lawry KW, Brouhard BH, Cunningham RJ (1994) Cognitive functioning and school performance in children with renal failure. Pediatr Nephrol 8:326–329CrossRefPubMed
29.
Bawden HN, Acott P, Carter J, Lirenman D, MacDonald GW, McAllister M, McDonnell MC, Shea S, Crocker J (2004) Neuropsychological functioning in end-stage renal disease. Arch Dis Child 89:644–647CrossRefPubMedPubMedCentral
30.
Gipson DS, Hooper SR, Duquette PJ, Wetherington CE, Stellwagen KK, Jenkins TL, Ferris ME (2006) Memory and executive function in pediatric chronic kidney disease. Child Neuropsychol 12:1–15CrossRef
31.
Quick CA (1976) Hearing loss in patients with dialysis and renal transplants. Ann Otol Rhinol Laryngol 85:776–790CrossRefPubMed
32.
Fennell R, Fennell E, Carter R, Mings E, Klausner A (1990) Association between renal function and cognition in childhood chronic renal failure. Pediatr Nephrol 4:16–20CrossRefPubMed
33.
Shoham DA, Vupputuri S, Kshirsagar AV (2005) Chronic kidney disease and life course socioeconomic status: a review. Adv Chronic Kidney Dis 12:56–63CrossRefPubMed
34.
U.S.Department of Education (2004) Digest of education statistics, 2003. National Center for Education Statistics, Washington, D.C.
35.
Groothoff JW, Grootenhuis M, Dommerholt A, Gruppen MP, Offringa M, Heymans HS (2002) Impaired cognition and schooling in adults with end stage renal disease since childhood. Arch Dis Child 87:380–385CrossRefPubMedPubMedCentral
36.
Broyer M, Le BC, Charbit M, Guest G, Tete MJ, Gagnadoux MF, Niaudet P (2004) Long-term social outcome of children after kidney transplantation. Transplantation 77:1033–1037CrossRefPubMed
37.
Bartosh SM, Leverson G, Robillard D, Sollinger HW (2003) Long-term outcomes in pediatric renal transplant recipients who survive into adulthood. Transplantation 76:1195–1200CrossRefPubMed
38.
Groothoff JW, Grootenhuis MA, Offringa M, Stronks K, Hutten GJ, Heymans HS (2005) Social consequences in adult life of end-stage renal disease in childhood. J Pediatr 146:512–517CrossRefPubMed
Metadata
Title
The central nervous system in childhood chronic kidney disease
Authors
Debbie S. Gipson
Peter J. Duquette
Phil F. Icard
Stephen R. Hooper
Publication date
01-10-2007
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-006-0269-1

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