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01-10-2007 | Brief Report

End-stage renal failure in adolescence with Sjögren’s syndrome autoantibodies SSA and SSB

Authors: Sally Johnson, Sally-Anne Hulton, Marie-Anne Brundler, Celia Moss, Aarnoud Huissoon, C. Mark Taylor

Published in: Pediatric Nephrology | Issue 10/2007

Abstract

We describe two adolescents who presented with end-stage renal failure and clinical features suggestive of Sjögren’s syndrome (SS). They both demonstrated severe, chronic, tubulointerstitial inflammation on renal biopsy, high-titre antinuclear antibodies, high immunoglobulin A and G concentrations, positive anti-SSA and anti-SSB antibodies, and negative anti-double-stranded DNA antibodies. One had subjective and objective evidence of the sicca complex (dry eyes and/or dry mouth) and fulfilled the commonly accepted SS consensus criteria. The other showed no evidence of the sicca complex but fulfilled modified criteria for juvenile SS. SS may be underrecognised as a cause of end-stage renal failure in childhood.

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Title: End-stage renal failure in adolescence with Sjögren’s syndrome autoantibodies SSA and SSB
Authors: Sally Johnson
Sally-Anne Hulton
Marie-Anne Brundler
Celia Moss
Aarnoud Huissoon
C. Mark Taylor
Publication date: 01-10-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0526-y

At a glance: The STEP trials

Springer Medicine

End-stage renal failure in adolescence with Sjögren’s syndrome autoantibodies SSA and SSB

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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