Top

Published in:

01-02-2006 | Brief Report

Renal tubular dysgenesis associated with in utero exposure to Nimuselide

Authors: Uma Sankari Ali, Sheila Khubchandani, Parmanand Andankar, Shashank Parekhji, Vishal Dubhalish, Bhavna Padhye

Published in: Pediatric Nephrology | Issue 2/2006

Abstract

Maternal ingestion of the selective cyclo-oxygenase-2 (COX-2) inhibitor Nimuselide has been reported to be associated with the development of oligohydramnios and neonatal renal failure in some cases. We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy. The neonate presented with metabolic acidosis and non-oliguric renal failure on the second day of life. The renal histopathology showed evidence of renal tubular dysgenesis. The child continues to have elevated serum creatinine and hypertension at 10 months of age.

Peruzzi L, Gianoglio B, Porcellini MG, Coppe R (1999) Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase type 1 selective inhibitor nimuselide as tocolytic. Lancet 354:1615CrossRefPubMed

Balasubramanian J (2000) Nimuselide and neonatal renal failure. Lancet 355:575CrossRef

Holmes RP, Stone PR (2000) Severe oligohydramnios induced by cyclooxygenase 2 inhibitor nimuselide. Obstet Gynecol 96:810–811CrossRefPubMed

Dinchuk JE, Car BD, Fochet RJ, Johnston JJ, Jaffe BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM (1995) Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 378:406–409CrossRefPubMed

Zhang MZ, Wang JL, Chang HF, Harris RC, Mc Kamna JA (1997) COX-2 in rat nephron development. Am J Physiology 273:F994–F1002

Allanson JE, Hunter AGW, Mettler GS, Jimenez C (1992) Renal tubular dysgenesis: not an uncommon autosomal recessive syndrome. A review. Am J Med Genet 43:811–814CrossRefPubMed

Pryde PG, Sedman AB, Nugent CE, Barr M Jr (1993) Angiotensin converting enzyme inhibitor fetopathy. J Am Soc Nephrol 3:1575–1582PubMed

Kaplan BS, Restaino I, Raval DS, Gottlieb RB, Bernstein J (1994) Renal failure in the neonate associated with in utero exposure to non-steroidal anti-inflammatory drugs. Pediatr Nephrol 8:700–704CrossRefPubMed

Voyer LE, Drut R, Mendez JH (1994) Fetal renal maldevelopment with oligohydramnios following maternal use of piroxicam. Pediatr Nephrol 8:592–594CrossRefPubMed

10.

Benini D, Fanos V, Cuzzolin L, Tato L (2004) In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. Pediatr Nephrol 19:232–234CrossRefPubMed

11.

Oberg KC, Pestaner JP Bielamosicz L, Hawkins EP (1999) Renal tubular dysgenesis in twin–twin transfusion syndrome. Pediatr Dev Pathol 2:25–32CrossRefPubMed

Title: Renal tubular dysgenesis associated with in utero exposure to Nimuselide
Authors: Uma Sankari Ali
Sheila Khubchandani
Parmanand Andankar
Shashank Parekhji
Vishal Dubhalish
Bhavna Padhye
Publication date: 01-02-2006
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 2/2006
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-005-2089-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Renal tubular dysgenesis associated with in utero exposure to Nimuselide

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2006

Muscular dystonia and athetosis in six patients with congenital nephrotic syndrome of the Finnish type (NPHS1)

Arterial hypertension after surgical closure of omphalocele and gastroschisis

Ontogeny of drug elimination by the human kidney

Experience of renal biopsy in children with nephrotic syndrome

Spurious hyperphosphatemia in a patient with alteplase-locked central venous catheter

Hypokalemia causing rhabdomyolysis resulting in life-threatening hyperkalemia