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Pediatric Nephrology
Published in: Pediatric Nephrology 12/2003

01-12-2003 | Original Article

The effects of corticosteroids on behavior in children with nephrotic syndrome

Authors: A. S. Hall, G. Thorley, P. N. Houtman

Published in: Pediatric Nephrology | Issue 12/2003

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Abstract

The objective of this study was to measure the frequency and severity of the behavioral effects of high-dose oral steroid therapy in children with nephrotic syndrome. We conducted a prospective assessment of the behavior of 12 children using a standardized psychological questionnaire at the time of diagnosis and again after 4 weeks of steroid therapy. A group of control children was also assessed. There was a significant increase in the total behavior score (P=0.03) and specifically in aggressive and poor attention behavior items in the group of nephrotic children compared with the control group. Four of the children with nephrotic syndrome developed abnormal behavior in the clinical range compared with none of the controls. In conclusion, children with nephrotic syndrome treated with high-dose oral steroids are at risk of developing clinically relevant behavioral changes.
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Metadata
Title
The effects of corticosteroids on behavior in children with nephrotic syndrome
Authors
A. S. Hall
G. Thorley
P. N. Houtman
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 12/2003
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1295-x

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