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Pediatric Nephrology
Published in: Pediatric Nephrology 12/2003

01-12-2003 | Brief Report

Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia

Authors: Larry A. Greenbaum, Bryce A. Kerlin, Scott Van Why, Rowena C. Punzalan, Beth A. Trost, Cynthia G. Pan, J. Paul Scott

Published in: Pediatric Nephrology | Issue 12/2003

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Abstract

We describe three cases of poststreptococcal glomerulonephritis (PSGN) associated with autoimmune hemolytic anemia. Along with the classic findings of PSGN, the patients had a positive direct antiglobulin test. Two patients had a cold-reacting anti-I autoantibody. This is the first description of this association. Autoimmune hemolytic anemia should be considered in children with PSGN and significant anemia or signs of hemolysis.
Literature
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Becker A, Gonzalez E, Vial S, Lagomarsino E, Taboada H, Donoso P, Solar E, Salgado C, Jara A, Grebe G (1994) La anemia de la glomerulonefritis aguda post-estreptococica. Rev Med Chil 122:1276–1282PubMed
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Ware RE, Rosse WF (1998) Autoimmune hemolytic anemia In: Nathan GT, Orkin SH (eds) Hematology of infancy and childhood. Saunders, Philadelphia, pp 499–522
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Sokol RJ, Hewitt S, Stamps BK (1981) Autoimmune haemolysis: an 18-year study of 865 cases referred to a regional transfusion centre. BMJ 282:2023–2027PubMed
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Greenberg J, Curtis-Cohen M, Gill FM, Cohen A (1980) Prolonged reticulocytopenia in autoimmune hemolytic anemia of childhood. J Pediatr 97:784–786PubMed
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Liesveld JL, Rowe JM, Lichtman MA (1987) Variability of the erythropoietic response in autoimmune hemolytic anemia: analysis of 109 cases. Blood 69:820–826PubMed
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Bailey RR, el-Maghraby M, Balfour IC, Mitchell TR (1972) Chronic glomerular nephritis in a man with an IgM cold autoantibody of anti-I specificity and a cold lymphocytotoxic antibody. J Clin Pathol 25:247–251PubMed
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Metadata
Title
Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia
Authors
Larry A. Greenbaum
Bryce A. Kerlin
Scott Van Why
Rowena C. Punzalan
Beth A. Trost
Cynthia G. Pan
J. Paul Scott
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 12/2003
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-003-1299-6

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