Skip to main content
Top
Published in: Surgical Endoscopy 5/2020

01-05-2020 | Laparoscopy

Prediction of early discharge after gynaecological oncology surgery within ERAS

Authors: Eric Lambaudie, Jérome Mathis, Christophe Zemmour, Camille Jauffret-Fara, Elie Toni Mikhael, Camille Pouliquen, Renaud Sabatier, Clément Brun, Marion Faucher, Djamel Mokart, Gilles Houvenaeghel

Published in: Surgical Endoscopy | Issue 5/2020

Login to get access

Abstract

Objectives

Enhanced recovery after surgery programs (ERAS) have been proven to decrease the length of hospital stay without increasing readmission rates or complications. However, the patient and operative characteristics that improve the chance of a successful early hospital discharge are not well established. The aim of this study was to design a nomogram which could be used before surgery, using the characteristics of patients, to establish who could benefit from early discharge (POD ≤ 2 days).

Methods

This observational study has been prospectively conducted. All the included patients were referred for surgical treatment of gynecologic cancer. We defined two sub-groups of patients on surgical procedure characteristics: isolated procedures (hysterectomy or lymphadenectomy) and combined procedures (at least the association of two procedures).

Results

230 patients were enrolled during the study protocol. 83.9% of patients were treated with a minimally invasive surgery (MIS). 159 patients (69.1%) were discharged on or before POD 2. On multivariate analysis, the surgical approach (open surgery vs. laparoscopy, OR  0.02 (95% CI [0–0.07]), p < 0.001) and the type of surgery (combined procedure versus isolated procedure, OR  0.41 (95% CI [0.18–0.91]), p = 0.028) were found to be significant predictors of increased hospital stay. A nomogram has been built for the purpose of predicting eligible patients for early post-operative discharge based on the multivariate analysis results (AUC = 0.86, 95% CI [0.81–0.92]).

Conclusion

The use of MIS for isolated procedures in oncologic indications constitutes an independent factor of early discharge in a setting of ERAS. These promising preliminary results still require to be validated on a prospective cohort.
Literature
1.
go back to reference Chapman JS, Roddy E, Ueda S et al (2016) Enhanced recovery pathways for improving outcomes after minimally invasive gynecologic oncology surgery. Obstet Gynecol 128(1):138–144PubMedCrossRef Chapman JS, Roddy E, Ueda S et al (2016) Enhanced recovery pathways for improving outcomes after minimally invasive gynecologic oncology surgery. Obstet Gynecol 128(1):138–144PubMedCrossRef
2.
go back to reference Nicholson A, Lowe MC, Parker J et al (2014) Systematic review and meta-analysis of enhanced recovery programmes in surgical patients. Br J Surg 101(3):172–188PubMedCrossRef Nicholson A, Lowe MC, Parker J et al (2014) Systematic review and meta-analysis of enhanced recovery programmes in surgical patients. Br J Surg 101(3):172–188PubMedCrossRef
3.
go back to reference Yoong W, Sivashanmugarajan V, Relph S et al (2014) Can enhanced recovery pathways improve outcomes of vaginal hysterectomy? Cohort control study. J Minim Invasive Gynecol 21(1):83–89PubMedCrossRef Yoong W, Sivashanmugarajan V, Relph S et al (2014) Can enhanced recovery pathways improve outcomes of vaginal hysterectomy? Cohort control study. J Minim Invasive Gynecol 21(1):83–89PubMedCrossRef
4.
go back to reference Kroon U-B, Rådström M, Hjelthe C et al (2010) Fast-track hysterectomy: a randomised, controlled study. Eur J Obstet Gynecol Reprod Biol 151(2):203–207PubMedCrossRef Kroon U-B, Rådström M, Hjelthe C et al (2010) Fast-track hysterectomy: a randomised, controlled study. Eur J Obstet Gynecol Reprod Biol 151(2):203–207PubMedCrossRef
5.
go back to reference Borendal Wodlin N, Nilsson L, Kjølhede P, GASPI study group (2011) The impact of mode of anaesthesia on postoperative recovery from fast-track abdominal hysterectomy: a randomised clinical trial. BJOG 118(3):299–308PubMedCrossRef Borendal Wodlin N, Nilsson L, Kjølhede P, GASPI study group (2011) The impact of mode of anaesthesia on postoperative recovery from fast-track abdominal hysterectomy: a randomised clinical trial. BJOG 118(3):299–308PubMedCrossRef
6.
go back to reference Minig L, Chuang L, Patrono MG et al (2015) Clinical outcomes after fast-track care in women undergoing laparoscopic hysterectomy. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet 131(3):301–304CrossRef Minig L, Chuang L, Patrono MG et al (2015) Clinical outcomes after fast-track care in women undergoing laparoscopic hysterectomy. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet 131(3):301–304CrossRef
7.
go back to reference Bruneau L, Randet M, Evrard S et al (2015) Total laparoscopic hysterectomy and same-day discharge: satisfaction evaluation and feasibility study. J Gynecol Obstet Biol Reprod 44(9):870–876CrossRef Bruneau L, Randet M, Evrard S et al (2015) Total laparoscopic hysterectomy and same-day discharge: satisfaction evaluation and feasibility study. J Gynecol Obstet Biol Reprod 44(9):870–876CrossRef
8.
go back to reference Chase DM, Lopez S, Nguyen C et al (2008) A clinical pathway for postoperative management and early patient discharge: does it work in gynecologic oncology? Am J Obstet Gynecol 199(5):541.e1–541.e7CrossRef Chase DM, Lopez S, Nguyen C et al (2008) A clinical pathway for postoperative management and early patient discharge: does it work in gynecologic oncology? Am J Obstet Gynecol 199(5):541.e1–541.e7CrossRef
9.
go back to reference Wijk L, Franzén K, Ljungqvist O et al (2016) Enhanced recovery after surgery protocol in abdominal hysterectomies for malignant versus benign disease. Gynecol Obstet Invest 81(5):461–467PubMedCrossRef Wijk L, Franzén K, Ljungqvist O et al (2016) Enhanced recovery after surgery protocol in abdominal hysterectomies for malignant versus benign disease. Gynecol Obstet Invest 81(5):461–467PubMedCrossRef
10.
go back to reference Lindemann K, Kok P-S, Stockler M et al (2017) Enhanced recovery after surgery for advanced ovarian cancer: a systematic review of interventions trialed. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 27(6):1274–1282CrossRef Lindemann K, Kok P-S, Stockler M et al (2017) Enhanced recovery after surgery for advanced ovarian cancer: a systematic review of interventions trialed. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 27(6):1274–1282CrossRef
11.
go back to reference Vlug MS, Wind J, Hollmann MW et al (2011) Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical trial (LAFA-study). Ann Surg 254(6):868–875PubMedCrossRef Vlug MS, Wind J, Hollmann MW et al (2011) Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical trial (LAFA-study). Ann Surg 254(6):868–875PubMedCrossRef
12.
go back to reference Schlaerth AC, Abu-Rustum NR (2006) Role of minimally invasive surgery in gynecologic cancers. Oncologist 11(8):895–901PubMedCrossRef Schlaerth AC, Abu-Rustum NR (2006) Role of minimally invasive surgery in gynecologic cancers. Oncologist 11(8):895–901PubMedCrossRef
13.
go back to reference Nelson G, Altman AD, Nick A et al (2016) Guidelines for pre- and intra-operative care in gynecologic/oncology surgery: enhanced Recovery After Surgery (ERAS®) Society recommendations–Part I. Gynecol Oncol 140(2):313–322PubMedCrossRef Nelson G, Altman AD, Nick A et al (2016) Guidelines for pre- and intra-operative care in gynecologic/oncology surgery: enhanced Recovery After Surgery (ERAS®) Society recommendations–Part I. Gynecol Oncol 140(2):313–322PubMedCrossRef
14.
go back to reference Nelson G, Altman AD, Nick A et al (2016) Guidelines for postoperative care in gynecologic/oncology surgery: enhanced Recovery After Surgery (ERAS®) Society recommendations–Part II. Gynecol Oncol 140(2):323–332PubMedPubMedCentralCrossRef Nelson G, Altman AD, Nick A et al (2016) Guidelines for postoperative care in gynecologic/oncology surgery: enhanced Recovery After Surgery (ERAS®) Society recommendations–Part II. Gynecol Oncol 140(2):323–332PubMedPubMedCentralCrossRef
15.
go back to reference Miralpeix E, Nick AM, Meyer LA et al (2016) A call for new standard of care in perioperative gynecologic oncology practice: impact of enhanced recovery after surgery (ERAS) programs. Gynecol Oncol 141(2):371–378PubMedPubMedCentralCrossRef Miralpeix E, Nick AM, Meyer LA et al (2016) A call for new standard of care in perioperative gynecologic oncology practice: impact of enhanced recovery after surgery (ERAS) programs. Gynecol Oncol 141(2):371–378PubMedPubMedCentralCrossRef
16.
go back to reference Kalogera E, Dowdy SC (2016) Enhanced recovery pathway in gynecologic surgery: improving outcomes through evidence-based medicine. Obstet Gynecol Clin North Am 43(3):551–573PubMedCrossRef Kalogera E, Dowdy SC (2016) Enhanced recovery pathway in gynecologic surgery: improving outcomes through evidence-based medicine. Obstet Gynecol Clin North Am 43(3):551–573PubMedCrossRef
17.
go back to reference Bauchat JR, Habib AS (2015) Evidence-based anesthesia for major gynecologic surgery. Anesthesiol Clin 33(1):173–207PubMedCrossRef Bauchat JR, Habib AS (2015) Evidence-based anesthesia for major gynecologic surgery. Anesthesiol Clin 33(1):173–207PubMedCrossRef
18.
go back to reference Lambaudie E, de Nonneville A, Brun C et al (2017) Enhanced recovery after surgery program in gynaecologic oncological surgery in a minimally invasive techniques expert center. BMC Surg 17(1):136PubMedPubMedCentralCrossRef Lambaudie E, de Nonneville A, Brun C et al (2017) Enhanced recovery after surgery program in gynaecologic oncological surgery in a minimally invasive techniques expert center. BMC Surg 17(1):136PubMedPubMedCentralCrossRef
19.
go back to reference Marx C, Rasmussen T, Jakobsen DH et al (2006) The effect of accelerated rehabilitation on recovery after surgery for ovarian malignancy. Acta Obstet Gynecol Scand 85(4):488–492PubMedCrossRef Marx C, Rasmussen T, Jakobsen DH et al (2006) The effect of accelerated rehabilitation on recovery after surgery for ovarian malignancy. Acta Obstet Gynecol Scand 85(4):488–492PubMedCrossRef
20.
go back to reference Nelson G, Bakkum-Gamez J, Kalogera E et al (2019) Guidelines for perioperative care in gynecologic/oncology: enhanced recovery after surgery (ERAS) society recommendations—2019 update. Int J Gynecol Cancer 29(4):651–668PubMedCrossRef Nelson G, Bakkum-Gamez J, Kalogera E et al (2019) Guidelines for perioperative care in gynecologic/oncology: enhanced recovery after surgery (ERAS) society recommendations—2019 update. Int J Gynecol Cancer 29(4):651–668PubMedCrossRef
21.
go back to reference Nelson G, Kalogera E, Dowdy SC (2014) Enhanced recovery pathways in gynecologic oncology. Gynecol Oncol 135(3):586–594PubMedCrossRef Nelson G, Kalogera E, Dowdy SC (2014) Enhanced recovery pathways in gynecologic oncology. Gynecol Oncol 135(3):586–594PubMedCrossRef
22.
go back to reference Schwartz AR, Lim S, Broadwater G et al (2019) Enhanced recovery after surgery protocol implementation was associated with decreased narcotic use, lower maximum pain scores, and expedited return of baseline functions among medically complex gynecologic oncology patients. Int J Gynecol Cancer. https://doi.org/10.1136/ijgc-2018-000131 PubMedCrossRef Schwartz AR, Lim S, Broadwater G et al (2019) Enhanced recovery after surgery protocol implementation was associated with decreased narcotic use, lower maximum pain scores, and expedited return of baseline functions among medically complex gynecologic oncology patients. Int J Gynecol Cancer. https://​doi.​org/​10.​1136/​ijgc-2018-000131 PubMedCrossRef
23.
go back to reference Wijk L, Franzen K, Ljungqvist O et al (2014) Implementing a structured enhanced recovery after surgery (ERAS) protocol reduces length of stay after abdominal hysterectomy. Acta Obstet Gynecol Scand 93(8):749–756PubMedCrossRef Wijk L, Franzen K, Ljungqvist O et al (2014) Implementing a structured enhanced recovery after surgery (ERAS) protocol reduces length of stay after abdominal hysterectomy. Acta Obstet Gynecol Scand 93(8):749–756PubMedCrossRef
25.
go back to reference Modesitt SC, Sarosiek BM, Trowbridge ER et al (2016) Enhanced recovery implementation in major gynecologic surgeries: effect of care standardization. Obstet Gynecol 128(3):457–466PubMedCrossRef Modesitt SC, Sarosiek BM, Trowbridge ER et al (2016) Enhanced recovery implementation in major gynecologic surgeries: effect of care standardization. Obstet Gynecol 128(3):457–466PubMedCrossRef
26.
go back to reference de Groot JJA, van Es LEJM, Maessen JMC et al (2014) Diffusion of enhanced recovery principles in gynecologic oncology surgery: is active implementation still necessary? Gynecol Oncol 134(3):570–575PubMedCrossRef de Groot JJA, van Es LEJM, Maessen JMC et al (2014) Diffusion of enhanced recovery principles in gynecologic oncology surgery: is active implementation still necessary? Gynecol Oncol 134(3):570–575PubMedCrossRef
27.
go back to reference Xu D, Li J, Song Y et al (2015) Laparoscopic surgery contributes more to nutritional and immunologic recovery than fast-track care in colorectal cancer. World J Surg Oncol 4(13):18CrossRef Xu D, Li J, Song Y et al (2015) Laparoscopic surgery contributes more to nutritional and immunologic recovery than fast-track care in colorectal cancer. World J Surg Oncol 4(13):18CrossRef
28.
go back to reference Wan KM, Carter J, Philp S (2016) Predictors of early discharge after open gynecological surgery in the setting of an enhanced recovery after surgery protocol. J Obstet Gynaecol Res 42(10):1369–1374PubMedCrossRef Wan KM, Carter J, Philp S (2016) Predictors of early discharge after open gynecological surgery in the setting of an enhanced recovery after surgery protocol. J Obstet Gynaecol Res 42(10):1369–1374PubMedCrossRef
29.
go back to reference Jackson KL, Glasgow RE, Hill BR et al (2013) Does travel distance influence length of stay in elective colorectal surgery? Dis Colon Rectum 56(3):367–373PubMedCrossRef Jackson KL, Glasgow RE, Hill BR et al (2013) Does travel distance influence length of stay in elective colorectal surgery? Dis Colon Rectum 56(3):367–373PubMedCrossRef
30.
go back to reference Jackson KL, Glasgow RE, Mone MC et al (2014) Does travel distance influence length of stay in elective pancreatic surgery? HPB 16(6):543–549PubMedCrossRef Jackson KL, Glasgow RE, Mone MC et al (2014) Does travel distance influence length of stay in elective pancreatic surgery? HPB 16(6):543–549PubMedCrossRef
31.
go back to reference Takenaka T, Inamasu E, Yoshida T et al (2016) Influence of the distance between home and the hospital on patients with surgically resected non-small-cell lung cancer. Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg 49(3):842–846CrossRef Takenaka T, Inamasu E, Yoshida T et al (2016) Influence of the distance between home and the hospital on patients with surgically resected non-small-cell lung cancer. Eur J Cardio-Thorac Surg Off J Eur Assoc Cardio-Thorac Surg 49(3):842–846CrossRef
32.
go back to reference Dickson EL, Stockwell E, Geller MA et al (2017) Enhanced recovery program and length of stay after laparotomy on a gynecologic oncology service: a randomized controlled trial. Obstet Gynecol 129(2):355–362PubMedPubMedCentralCrossRef Dickson EL, Stockwell E, Geller MA et al (2017) Enhanced recovery program and length of stay after laparotomy on a gynecologic oncology service: a randomized controlled trial. Obstet Gynecol 129(2):355–362PubMedPubMedCentralCrossRef
33.
go back to reference Singh S, Swarer K, Resnick K (2017) Longer operative time is associated with increased post-operative complications in patients undergoing minimally-invasive surgery for endometrial cancer. Gynecol Oncol 147(3):554–557PubMedCrossRef Singh S, Swarer K, Resnick K (2017) Longer operative time is associated with increased post-operative complications in patients undergoing minimally-invasive surgery for endometrial cancer. Gynecol Oncol 147(3):554–557PubMedCrossRef
34.
go back to reference Touijer K, Scardino PT (2009) Nomograms for staging, prognosis, and predicting treatment outcomes. Cancer 115(13 Suppl):3107–3111PubMedCrossRef Touijer K, Scardino PT (2009) Nomograms for staging, prognosis, and predicting treatment outcomes. Cancer 115(13 Suppl):3107–3111PubMedCrossRef
35.
go back to reference Potters L, Roach M, Davis BJ et al (2010) Postoperative nomogram predicting the 9-year probability of prostate cancer recurrence after permanent prostate brachytherapy using radiation dose as a prognostic variable. Int J Radiat Oncol Biol Phys 76(4):1061–1065PubMedCrossRef Potters L, Roach M, Davis BJ et al (2010) Postoperative nomogram predicting the 9-year probability of prostate cancer recurrence after permanent prostate brachytherapy using radiation dose as a prognostic variable. Int J Radiat Oncol Biol Phys 76(4):1061–1065PubMedCrossRef
36.
go back to reference Nixon IJ, Ganly I, Hann LE et al (2010) Nomogram for predicting malignancy in thyroid nodules using clinical, biochemical, ultrasonographic, and cytologic features. Surgery 148(6):1120–1127PubMedCrossRef Nixon IJ, Ganly I, Hann LE et al (2010) Nomogram for predicting malignancy in thyroid nodules using clinical, biochemical, ultrasonographic, and cytologic features. Surgery 148(6):1120–1127PubMedCrossRef
37.
go back to reference Barsoum WK, Murray TG, Klika AK et al (2010) Predicting patient discharge disposition after total joint arthroplasty in the United States. J Arthroplasty 25(6):885–892PubMedCrossRef Barsoum WK, Murray TG, Klika AK et al (2010) Predicting patient discharge disposition after total joint arthroplasty in the United States. J Arthroplasty 25(6):885–892PubMedCrossRef
38.
go back to reference Kelly DM, Bennett R, Brown N et al (2012) Predicting the discharge status after liver transplantation at a single center: a new approach for a new era. Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc 18(7):796–802 Kelly DM, Bennett R, Brown N et al (2012) Predicting the discharge status after liver transplantation at a single center: a new approach for a new era. Liver Transplant Off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc 18(7):796–802
40.
go back to reference Schiavone MB, Herzog TJ, Ananth CV et al (2012) Feasibility and economic impact of same-day discharge for women who undergo laparoscopic hysterectomy. Am J Obstet Gynecol 207(5):382.e1–382.e9CrossRef Schiavone MB, Herzog TJ, Ananth CV et al (2012) Feasibility and economic impact of same-day discharge for women who undergo laparoscopic hysterectomy. Am J Obstet Gynecol 207(5):382.e1–382.e9CrossRef
41.
go back to reference Philp S, Carter J, Barnett C et al (2015) Patients’ perspectives of fast-track surgery and the role of the fast-track clinical nurse consultant in gynecological oncology. Holist Nurs Pract 29(3):158–166PubMedCrossRef Philp S, Carter J, Barnett C et al (2015) Patients’ perspectives of fast-track surgery and the role of the fast-track clinical nurse consultant in gynecological oncology. Holist Nurs Pract 29(3):158–166PubMedCrossRef
Metadata
Title
Prediction of early discharge after gynaecological oncology surgery within ERAS
Authors
Eric Lambaudie
Jérome Mathis
Christophe Zemmour
Camille Jauffret-Fara
Elie Toni Mikhael
Camille Pouliquen
Renaud Sabatier
Clément Brun
Marion Faucher
Djamel Mokart
Gilles Houvenaeghel
Publication date
01-05-2020
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 5/2020
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-019-06974-w

Other articles of this Issue 5/2020

Surgical Endoscopy 5/2020 Go to the issue