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Surgical Endoscopy

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01-06-2017

Preoperative localization of colorectal cancer: a systematic review and meta-analysis

Authors: Sergio A. Acuna, Maryam Elmi, Prakesh S. Shah, Natalie G. Coburn, Fayez A. Quereshy

Published in: Surgical Endoscopy | Issue 6/2017

Abstract

Background

Preoperative colorectal tumor localization is crucial for appropriate resection and treatment planning. As the localization accuracy of conventional colonoscopy is considered to be low, several localization techniques have been developed. We systematically reviewed the tumor localization error rates of several preoperative endoscopic techniques and synthesized information on risk factors for localization errors and procedure-related adverse events.

Methods

MEDLINE, EMBASE, the Cochrane Library, and the grey literature were searched. Studies were included if they reported tumor localization errors in patients with colorectal cancer undergoing resection with curative intent. Using random-effects models, pooled incidence of tumor localization errors were derived for conventional colonoscopy and colonoscopic tattooing. Due to the lack of comparative studies, a direct comparison of the pooled estimates was performed. Procedure-related adverse events, risk factors for localization errors, and the localization outcomes of other techniques such as colonoscopic clip placement, radioguided occult colonic lesion identification, and the use of magnetic endoscope imaging were also synthesized.

Results

A total of 38 non-randomized controlled and observational studies were included in this review (2578 patients underwent conventional colonoscopy and 643 colonoscopic tattooing). The pooled incidence of localization errors with conventional colonoscopy was 15.4 % (95 % CI 12.0–18.7), whereas that of colonoscopic tattooing was 9.5 % (95 % CI 5.7–13.3), mean difference 5.9 % (95 % CI 0.65–11.14, p = 0.03). Adverse events secondary to tattooing were infrequent, and most were cases of ink spillage. Limited information was available for other localization techniques.

Conclusion

Conventional colonoscopy has a higher incidence of localization error compared to colonoscopic tattooing for localization of colorectal cancer. Colonoscopic tattooing is safe and leads to fewer tumor localization errors. Given the widespread adoption of laparoscopic resections for colorectal cancer, routine colonoscopic tattooing should be adopted. However, studies directly comparing different localization techniques are needed.

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Title: Preoperative localization of colorectal cancer: a systematic review and meta-analysis
Authors: Sergio A. Acuna
Maryam Elmi
Prakesh S. Shah
Natalie G. Coburn
Fayez A. Quereshy
Publication date: 01-06-2017
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 6/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-016-5236-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Preoperative localization of colorectal cancer: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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