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01-02-2017

Comparison of oncological results for early- and advanced-stage thymomas: thoracoscopic thymectomy versus open thymectomy

Authors: Makoto Odaka, Takamasa Shibasaki, Daiki Kato, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Toshiaki Morikawa

Published in: Surgical Endoscopy | Issue 2/2017

Abstract

Background

This study evaluated the feasibility of thoracoscopic thymectomy (TT) for the treatment of early- and advanced-stage thymoma and compared patient outcomes with those following open thymectomy (OT).

Methods

A retrospective review was conducted for 140 patients who underwent TT or OT for Masaoka stage I–IV thymoma between 1996 and 2014.

Results

TT was performed in 88 patients and OT in 52 patients. The postoperative hospital stay was significantly shorter in the TT group than in the OT group (4 and 13 days, respectively; P < 0.0001). WHO types B3–C were identified in Masaoka stage III–IV disease with high frequency. There was a significant relationship between Masaoka stage and WHO type (P < 0.05); the numbers of advanced-stage thymoma progressively increased in WHO type B3–C. Eight patients in each group had recurrent disease, with greater recurrence for WHO types B3–C and stage III–IV tumors. Five-year disease-free survival (DFS) was not different between groups (P = 0.3906); however, survival for patients with stage III–IV thymomas (47 %) was significantly worse than that for patients with stage I and II tumors (97.5 and 94.1 %, respectively; P < 0.0001). Based on multivariate analysis, both Masaoka stage and WHO type were significant predictors of thymoma patient survival.

Conclusions

These results demonstrate the safety and substantially decreased invasiveness of TT for thymoma. The oncological results were comparable between the TT and OT groups. Furthermore, Masaoka stage III–IV and WHO B3–C were revealed as independent prognostic factors for DFS.

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Title: Comparison of oncological results for early- and advanced-stage thymomas: thoracoscopic thymectomy versus open thymectomy
Authors: Makoto Odaka
Takamasa Shibasaki
Daiki Kato
Shohei Mori
Hisatoshi Asano
Makoto Yamashita
Toshiaki Morikawa
Publication date: 01-02-2017
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 2/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-016-5027-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparison of oncological results for early- and advanced-stage thymomas: thoracoscopic thymectomy versus open thymectomy

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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