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Published in: Surgical Endoscopy 2/2017

01-02-2017

Application of novel endoloops to close the defects resulted from endoscopic full-thickness resection with single-channel gastroscope: a multicenter study

Authors: Dongtao Shi, Rui Li, Weichang Chen, Deqing Zhang, Lei Zhang, Rui Guo, Ping Yao, Xudong Wu

Published in: Surgical Endoscopy | Issue 2/2017

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Abstract

Background

The key step of the endoscopic full-thickness resection (EFTR) procedure is the successful closure of any gastric wall defect which ultimately avoids surgical intervention. This report presents a new method of closing large gastric defects left after EFTR, using metallic clips and novel endoloops by means of single-channel endoscope.

Methods

We retrospectively analyzed 68 patients who were treated for gastric fundus gastrointestinal stromal tumors originating from the muscularis propria layer at four institutes between April 2014 and February 2015 and consequently underwent EFTR. The large gastric post-EFTR defects were completely closed with metallic clips and novel endoloops using single-channel endoscope, and all the patients were discharged with subsequent endoscopic and clinical follow-up. Patient characteristics, tumor size, en bloc resection rate, closure operation time, and postoperative adverse events were evaluated.

Results

EFTR was successfully performed on 68 patients [41 male (60 %), 27 female (40 %); median age 61 years, range 38–73], and the en bloc resection rate was 100 %. Complete closure of all the gastric post-EFTR defects was achieved (success rate 100 %). The mean closure operation time was 13 min (range 9–21 min). The mean maximum size of the lesions was 2.6 cm (range 2.0–3.5 cm). One Mallory–Weiss syndrome and one delayed bleeding were resolved with nonsurgical treatment. The wounds were healed in all cases 1 month after the procedure.

Conclusions

The use of metallic clips and novel endoloops with single-channel endoscope is a relatively safe, easy, and feasible method for repairing large gastric post-EFTR defects.
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Literature
1.
go back to reference Akahoshi K, Sumida Y, Matsui N et al (2007) Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration. World J Gastroenterol 13(14):2077–2082CrossRefPubMedPubMedCentral Akahoshi K, Sumida Y, Matsui N et al (2007) Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration. World J Gastroenterol 13(14):2077–2082CrossRefPubMedPubMedCentral
2.
go back to reference Miettinen M, Sobin LH, Lasota J (2005) Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 29(1):52–68CrossRefPubMed Miettinen M, Sobin LH, Lasota J (2005) Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 29(1):52–68CrossRefPubMed
3.
go back to reference Demetri GD, von Mehren M, Antonescu CR et al (2010) NCCN Task Force Report: update on the management of patients with gastrointestinal stromal tumors. J Natl Comp Cancer Netw 8(Suppl 2):S1–S41 Demetri GD, von Mehren M, Antonescu CR et al (2010) NCCN Task Force Report: update on the management of patients with gastrointestinal stromal tumors. J Natl Comp Cancer Netw 8(Suppl 2):S1–S41
4.
go back to reference Zhou PH, Yao LQ, Qin XY et al (2011) Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors originated from the muscularis propria. Surg Endosc 25(9):2926–2931CrossRefPubMed Zhou PH, Yao LQ, Qin XY et al (2011) Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors originated from the muscularis propria. Surg Endosc 25(9):2926–2931CrossRefPubMed
5.
go back to reference von Renteln D, Rösch T, Kratt T et al (2012) Endoscopic full-thickness resection of submucosal gastric tumors. Dig Dis Sci 57(5):1298–1303CrossRef von Renteln D, Rösch T, Kratt T et al (2012) Endoscopic full-thickness resection of submucosal gastric tumors. Dig Dis Sci 57(5):1298–1303CrossRef
6.
go back to reference Schlag C, Wilhelm D, von Delius S et al (2012) EndoResect study: endoscopic full-thickness resection of gastric subepithelial tumors. Endoscopy 45(1):4–11PubMed Schlag C, Wilhelm D, von Delius S et al (2012) EndoResect study: endoscopic full-thickness resection of gastric subepithelial tumors. Endoscopy 45(1):4–11PubMed
7.
go back to reference Schmidt A, Bauder M, Riecken B et al (2015) Endoscopic full-thickness resection of gastric subepithelial tumors: a single-center series. Endoscopy 47(2):154–158PubMed Schmidt A, Bauder M, Riecken B et al (2015) Endoscopic full-thickness resection of gastric subepithelial tumors: a single-center series. Endoscopy 47(2):154–158PubMed
8.
go back to reference Kopelman Y, Siersema PD, Bapaye A et al (2012) Endoscopic full-thickness GI wall resection: current status. Gastrointest Endosc 75(1):165–173CrossRefPubMed Kopelman Y, Siersema PD, Bapaye A et al (2012) Endoscopic full-thickness GI wall resection: current status. Gastrointest Endosc 75(1):165–173CrossRefPubMed
9.
go back to reference Li QL, Yao LQ, Zhou PH et al (2012) Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video). Gastrointest Endosc 75(6):1153–1158CrossRefPubMed Li QL, Yao LQ, Zhou PH et al (2012) Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video). Gastrointest Endosc 75(6):1153–1158CrossRefPubMed
10.
go back to reference Zhang Y, Wang X, Xiong G et al (2014) Complete defect closure of gastric submucosal tumors with purse-string sutures. Surg Endosc 28(6):1844–1851CrossRefPubMed Zhang Y, Wang X, Xiong G et al (2014) Complete defect closure of gastric submucosal tumors with purse-string sutures. Surg Endosc 28(6):1844–1851CrossRefPubMed
11.
go back to reference Shi Q, Chen T, Zhong YS et al (2013) Complete closure of large gastric defects after endoscopic full-thickness resection, using endoloop and metallic clip interrupted suture. Endoscopy 45(5):329–334CrossRefPubMed Shi Q, Chen T, Zhong YS et al (2013) Complete closure of large gastric defects after endoscopic full-thickness resection, using endoloop and metallic clip interrupted suture. Endoscopy 45(5):329–334CrossRefPubMed
12.
go back to reference Ye LP, Yu Z, Mao XL et al (2014) Endoscopic full-thickness resection with defect closure using clips and an endoloop for gastric subepithelial tumors arising from the muscularis propria. Surg Endosc 28(6):1978–1983CrossRefPubMed Ye LP, Yu Z, Mao XL et al (2014) Endoscopic full-thickness resection with defect closure using clips and an endoloop for gastric subepithelial tumors arising from the muscularis propria. Surg Endosc 28(6):1978–1983CrossRefPubMed
13.
go back to reference Miettinen M, Lasota J (2006) Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 23(2):70–83CrossRefPubMed Miettinen M, Lasota J (2006) Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 23(2):70–83CrossRefPubMed
14.
go back to reference Joensuu H (2008) Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol 39:1411–1419CrossRefPubMed Joensuu H (2008) Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol 39:1411–1419CrossRefPubMed
15.
go back to reference Cioffi A, Maki RG (2015) GI stromal tumors: 15 years of lessons from a rare cancer. J Clin Oncol 33(16):1849–1854CrossRefPubMed Cioffi A, Maki RG (2015) GI stromal tumors: 15 years of lessons from a rare cancer. J Clin Oncol 33(16):1849–1854CrossRefPubMed
16.
go back to reference Sepe PS, Brugge WR (2009) A guide for the diagnosis and management of gastrointestinal stromal cell tumors. Nat Rev Gastroenterol Hepatol 6(6):363–371CrossRefPubMed Sepe PS, Brugge WR (2009) A guide for the diagnosis and management of gastrointestinal stromal cell tumors. Nat Rev Gastroenterol Hepatol 6(6):363–371CrossRefPubMed
17.
go back to reference Nishida T, Hirota S, Yanagisawa A et al (2008) Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version. Int J Clin Oncol 13(5):416–430CrossRefPubMed Nishida T, Hirota S, Yanagisawa A et al (2008) Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version. Int J Clin Oncol 13(5):416–430CrossRefPubMed
18.
go back to reference Hwang JH, Rulyak SD, Kimmey MB, Institute Association (2006) American Gastroenterological American Gastroenterological Association Institute technical review on the management of gastric subepithelial masses. Gastroenterology 130(7):2217–2228CrossRefPubMed Hwang JH, Rulyak SD, Kimmey MB, Institute Association (2006) American Gastroenterological American Gastroenterological Association Institute technical review on the management of gastric subepithelial masses. Gastroenterology 130(7):2217–2228CrossRefPubMed
19.
go back to reference Blay JY, Bonvalot S, Casali P GIST Consensus Meeting Panelists et al (2005) Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO. Ann Oncol 16(6):566–578 Blay JY, Bonvalot S, Casali P GIST Consensus Meeting Panelists et al (2005) Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO. Ann Oncol 16(6):566–578
20.
go back to reference ESMO/European Sarcoma Network Working Group (2012) Gastrointestinal stromal tumors: ESMO clinical practice guide-lines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii49–vii55 ESMO/European Sarcoma Network Working Group (2012) Gastrointestinal stromal tumors: ESMO clinical practice guide-lines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii49–vii55
22.
go back to reference Shen C, Chen H, Yin Y et al (2015) Endoscopic versus open resection for small gastric gastrointestinal stromal tumors: safety and outcomes. Med (Baltimore) 94(1):1–7CrossRef Shen C, Chen H, Yin Y et al (2015) Endoscopic versus open resection for small gastric gastrointestinal stromal tumors: safety and outcomes. Med (Baltimore) 94(1):1–7CrossRef
23.
go back to reference Raju GS (2011) Gastrointestinal perforations: role of endoscopic closure. Curr Opin Gastroenterol 27(5):418–422CrossRefPubMed Raju GS (2011) Gastrointestinal perforations: role of endoscopic closure. Curr Opin Gastroenterol 27(5):418–422CrossRefPubMed
24.
go back to reference Raju GS (2014) Endoscopic clip closure of gastrointestinal perforations, fistulae, and leaks. Dig Endosc 26(Suppl 1):95–104CrossRefPubMed Raju GS (2014) Endoscopic clip closure of gastrointestinal perforations, fistulae, and leaks. Dig Endosc 26(Suppl 1):95–104CrossRefPubMed
25.
go back to reference Al Ghossaini N, Lucidarme D, Bulois P (2014) Endoscopic treatment of iatrogenic gastrointestinal perforations: an overview. Dig Liver Dis 46(3):195–203CrossRefPubMed Al Ghossaini N, Lucidarme D, Bulois P (2014) Endoscopic treatment of iatrogenic gastrointestinal perforations: an overview. Dig Liver Dis 46(3):195–203CrossRefPubMed
26.
go back to reference Mangiavillano B, Viaggi P, Masci E (2010) Endoscopic closure of acute iatrogenic perforations during diagnostic and therapeutic endoscopy in the gastrointestinal tract using metallic clips: a literature review. J Dig Dis 11(1):12–18CrossRefPubMed Mangiavillano B, Viaggi P, Masci E (2010) Endoscopic closure of acute iatrogenic perforations during diagnostic and therapeutic endoscopy in the gastrointestinal tract using metallic clips: a literature review. J Dig Dis 11(1):12–18CrossRefPubMed
27.
go back to reference Kantsevoy SV, Bitner M, Mitrakov AA et al (2014) Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc 79(3):503–507CrossRefPubMed Kantsevoy SV, Bitner M, Mitrakov AA et al (2014) Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc 79(3):503–507CrossRefPubMed
28.
go back to reference Paspatis GA, Dumonceau JM, Barthet M et al (2014) Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) position statement. Endoscopy 46(8):693–711CrossRefPubMed Paspatis GA, Dumonceau JM, Barthet M et al (2014) Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) position statement. Endoscopy 46(8):693–711CrossRefPubMed
29.
go back to reference Schmidt A, Damm M, Caca K (2014) Endoscopic full-thickness resection using a novel over-the-scope device. Gastroenterology 147(4):740–742CrossRefPubMed Schmidt A, Damm M, Caca K (2014) Endoscopic full-thickness resection using a novel over-the-scope device. Gastroenterology 147(4):740–742CrossRefPubMed
30.
go back to reference Samarasena JB, Nakai Y, Park DH et al (2012) Endoscopic closure of an iatrogenic duodenal perforation: a novel technique using endoclips, endoloop, and fibrin glue. Endoscopy 44(Suppl 2):E424–E425PubMed Samarasena JB, Nakai Y, Park DH et al (2012) Endoscopic closure of an iatrogenic duodenal perforation: a novel technique using endoclips, endoloop, and fibrin glue. Endoscopy 44(Suppl 2):E424–E425PubMed
Metadata
Title
Application of novel endoloops to close the defects resulted from endoscopic full-thickness resection with single-channel gastroscope: a multicenter study
Authors
Dongtao Shi
Rui Li
Weichang Chen
Deqing Zhang
Lei Zhang
Rui Guo
Ping Yao
Xudong Wu
Publication date
01-02-2017
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 2/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-016-5041-4

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