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Published in:

01-11-2016

Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection

Authors: Pedro Moya, Elena Miranda, Leticia Soriano-Irigaray, Antonio Arroyo, Maria-del-Mar Aguilar, Marta Bellón, Jose-Luis Muñoz, Fernando Candela, Rafael Calpena

Published in: Surgical Endoscopy | Issue 11/2016

Abstract

Objective

To determine whether the joint implementation of immunonutrition and a laparoscopic approach improves morbidity, mortality, and length of stay (LOS) compared with dietary advice.

Background

Despite progress in recent years in the surgical management of patients with colorectal cancer, postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the immunonutrition benefits in patients undergoing colorectal laparoscopic surgery are unknown.

Methods

This study was a prospective, randomized trial with two parallel treatment groups receiving an immune-enhancing dietary supplement for 7 days before colorectal resection and 5 days postoperatively or dietary advice.

Results

A total of 128 patients were randomized. At baseline, both groups were comparable with respect to age, sex, surgical risk, comorbidities, and analytical and nutritional parameters. The median postoperative LOS was 5 days and was not significantly different between the groups. Wound infection differed significantly between the groups (11.50 vs. 0.00 %, p = 0.006). No other differences between the groups were identified.

Conclusions

The joint use of laparoscopy and supplementation with immunonutrients reduces surgical wound infection in patients undergoing colorectal surgery.

Trial registration

This study is registered with ClinicalTrial.gov: NCT0239396.

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Title: Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection
Authors: Pedro Moya
Elena Miranda
Leticia Soriano-Irigaray
Antonio Arroyo
Maria-del-Mar Aguilar
Marta Bellón
Jose-Luis Muñoz
Fernando Candela
Rafael Calpena
Publication date: 01-11-2016
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 11/2016
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-016-4836-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection

Abstract

Objective

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Background

Methods

Results

Conclusions

Trial registration

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