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Published in:

01-10-2016

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Authors: Do Hyun Jung, Sang Yong Son, Aung Myint Oo, Young Suk Park, Dong Joon Shin, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim

Published in: Surgical Endoscopy | Issue 10/2016

Abstract

Background

Peritoneal carcinomatosis is an unmet therapeutic need. Several types of intraperitoneal chemotherapy have been introduced. However, hyperthermic intraperitoneal chemotherapy has limited drug distribution and poor peritoneal penetration. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) does not have the benefits of hyperthermia. We developed a device to apply hyperthermic PIPAC (H-PAC) and evaluated its feasibility in a porcine model.

Methods

The device for H-PAC consisted of a laparoscopic aerosol spray and a heater to create hyperthermic capnoperitoneum. We operated on five pigs for the development of the new device and on another five pigs as a survival model. After a pilot experiment of the survival model (Pig A), a hyperthermic pressurized intraperitoneal aerosol of indocyanine green was administered after insertion of three trocars (Pig B) and laparoscopy-assisted distal gastrectomy (LADG) (Pig C) without chemotherapeutic agents. After that, H-PAC with cisplatin was administered after insertion of three trocars (Pig D) and LADG (Pig E). Autopsies were performed on postoperative day 7.

Results

Median operation time was 85 min (80–110 min). Intraperitoneal temperature was constant for 1 h of H-PAC (38.8–40.2 °C). All five pigs were healthy and survived for 7 days. Median weight loss was 0.2 kg. Autopsy tissues of stomach, peritoneum, and jejunum were intact in all five pigs.

Conclusions

H-PAC was feasible and safe in a porcine model.

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Title: Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model
Authors: Do Hyun Jung
Sang Yong Son
Aung Myint Oo
Young Suk Park
Dong Joon Shin
Sang-Hoon Ahn
Do Joong Park
Hyung-Ho Kim
Publication date: 01-10-2016
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 10/2016
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-015-4738-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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