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Published in: Surgical Endoscopy 7/2016

Open Access 01-07-2016 | Dynamic Manuscript

Risk factors for infection after endoscopic ultrasonography-guided drainage of specific types of pancreatic and peripancreatic fluid collections (with video)

Authors: Jintao Guo, Linlin Feng, Siyu Sun, Nan Ge, Xiang Liu, Sheng Wang, Guoxin Wang, Beibei Sun

Published in: Surgical Endoscopy | Issue 7/2016

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Abstract

Background

Endoscopic ultrasonography (EUS)-guided drainage is widely used for the treatment of specific types of peripancreatic fluid collections (PFCs). Infectious complications have been reported. It is recommended that the infection rate should be assessed by measuring risk factors. The objectives of this study were to measure whether the risk of infection after EUS-guided drainage was associated with patient- and procedure-related factors.

Methods

Eighty-three patients were eligible for inclusion from September 2008 to November 2012. EUS-guided drainage was performed in all patients. Infectious complications were observed, and data on patient- and procedure-related factors were collected. Patient-related factors mainly included age, sex, etiology of PFC, and cyst location and diameter. Procedure-related factors mainly included approach of EUS-guided drainage and stent diameter. Separate multivariate logistic regression models for all EUS-guided drainage were carried out.

Results

Complete EUS-guided drainage was achieved in all patients. A definitive diagnosis of infection after EUS-guided drainage was made in seven patients. All seven patients had a history of acute pancreatitis, and the cyst diameters were all >15 cm. Three patients had diabetes mellitus.

Conclusions

The cyst diameter was an independent risk factor for infection. Larger cysts with a diameter >15 cm should perhaps be drained initially with multiple pigtail or a larger diameter self-expandable metal stents to try to avoid infection.
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Literature
1.
go back to reference Varadarajulu S, Christein JD, Tamhane A, Drelichman ER, Wilcox CM (2008) Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts (with videos). Gastrointest Endosc 68:1102–1111CrossRefPubMed Varadarajulu S, Christein JD, Tamhane A, Drelichman ER, Wilcox CM (2008) Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts (with videos). Gastrointest Endosc 68:1102–1111CrossRefPubMed
2.
go back to reference Baron TH, Harewood GC, Morgan DE, Yates MR (2002) Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 56:7–17CrossRefPubMed Baron TH, Harewood GC, Morgan DE, Yates MR (2002) Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 56:7–17CrossRefPubMed
3.
go back to reference Cahen D, Rauws E, Fockens P, Weverling G, Huibregtse K, Bruno M (2005) Endoscopic drainage of pancreatic pseudocysts: long-term outcome and procedural factors associated with safe and successful treatment. Endoscopy 37(10):977–983CrossRefPubMed Cahen D, Rauws E, Fockens P, Weverling G, Huibregtse K, Bruno M (2005) Endoscopic drainage of pancreatic pseudocysts: long-term outcome and procedural factors associated with safe and successful treatment. Endoscopy 37(10):977–983CrossRefPubMed
4.
go back to reference Binmoeller KF, Weilert F, Shah JN, Bhat YM, Kane S (2013) Endosonography-guided transmural drainage of pancreatic pseudocysts using an exchange-free access device: initial clinical experience. Surg Endosc 27(5):1835–1839CrossRefPubMed Binmoeller KF, Weilert F, Shah JN, Bhat YM, Kane S (2013) Endosonography-guided transmural drainage of pancreatic pseudocysts using an exchange-free access device: initial clinical experience. Surg Endosc 27(5):1835–1839CrossRefPubMed
5.
go back to reference Săftoiu A, Ciobanu L, Seicean A, Tantău M (2013) Arterial bleeding during EUS-guided pseudocyst drainage stopped by placement of a covered self-expandable metal stent. BMC Gastroenterol 13:93CrossRefPubMedPubMedCentral Săftoiu A, Ciobanu L, Seicean A, Tantău M (2013) Arterial bleeding during EUS-guided pseudocyst drainage stopped by placement of a covered self-expandable metal stent. BMC Gastroenterol 13:93CrossRefPubMedPubMedCentral
6.
go back to reference Varadarajulu S, Bang JY, Sutton BS, Trevino JM, Christein JD, Wilcox CM (2013) Equal efficacy of endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage in a randomized trial. Gastroenterology 145(3):583–590CrossRefPubMed Varadarajulu S, Bang JY, Sutton BS, Trevino JM, Christein JD, Wilcox CM (2013) Equal efficacy of endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage in a randomized trial. Gastroenterology 145(3):583–590CrossRefPubMed
7.
go back to reference Zerem E, Pavlović-Čalić N, Haračić B (2014) Comparative evaluation of outcomes of endoscopic versus percutaneous drainage for symptomatic pancreatic pseudocysts. Gastrointest Endosc 79(6):1028CrossRefPubMed Zerem E, Pavlović-Čalić N, Haračić B (2014) Comparative evaluation of outcomes of endoscopic versus percutaneous drainage for symptomatic pancreatic pseudocysts. Gastrointest Endosc 79(6):1028CrossRefPubMed
8.
go back to reference Rodriguez JR, Razo AO, Targarona J, Thayer SP, Rattner DW, Warshaw AL, Fernández-del Castillo C (2008) Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients. Ann Surg 247:294–299CrossRefPubMedPubMedCentral Rodriguez JR, Razo AO, Targarona J, Thayer SP, Rattner DW, Warshaw AL, Fernández-del Castillo C (2008) Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients. Ann Surg 247:294–299CrossRefPubMedPubMedCentral
9.
go back to reference Akshintala VS, Saxena P, Zaheer A, Rana U, Hutfless SM, Lennon AM, Canto MI, Kalloo AN, Khashab MA, Singh VK (2014) A comparative evaluation of outcomes of endoscopic versus percutaneous drainage for symptomatic pancreatic pseudocysts. Gastrointest Endosc 79(6):921–928CrossRefPubMed Akshintala VS, Saxena P, Zaheer A, Rana U, Hutfless SM, Lennon AM, Canto MI, Kalloo AN, Khashab MA, Singh VK (2014) A comparative evaluation of outcomes of endoscopic versus percutaneous drainage for symptomatic pancreatic pseudocysts. Gastrointest Endosc 79(6):921–928CrossRefPubMed
10.
go back to reference Kahaleh M, Shami VM, Conaway MR, Tokar J, Rockoff T, De La Rue SA, de Lange E, Bassignani M, Gay S, Adams RB, Yeaton P (2006) Endoscopic ultrasound drainage of pancreatic pseudocyst: a prospective comparison with conventional endoscopic drainage. Endoscopy 38:355–359CrossRefPubMed Kahaleh M, Shami VM, Conaway MR, Tokar J, Rockoff T, De La Rue SA, de Lange E, Bassignani M, Gay S, Adams RB, Yeaton P (2006) Endoscopic ultrasound drainage of pancreatic pseudocyst: a prospective comparison with conventional endoscopic drainage. Endoscopy 38:355–359CrossRefPubMed
11.
go back to reference Varadarajulu S, Lopes TL, Wilcox CM, Drelichman ER, Kilgore ML, Christein JD (2008) EUS versus surgical cyst-gastrostomy for management of pancreatic pseudocysts. Gastrointest Endosc 68:649–655CrossRefPubMed Varadarajulu S, Lopes TL, Wilcox CM, Drelichman ER, Kilgore ML, Christein JD (2008) EUS versus surgical cyst-gastrostomy for management of pancreatic pseudocysts. Gastrointest Endosc 68:649–655CrossRefPubMed
12.
go back to reference Singhal S, Rotman SR, Gaidhane M, Kahaleh M (2013) Pancreatic fluid collection drainage by endoscopic ultrasound: an update. Clin Endosc 46(5):506–514CrossRefPubMedPubMedCentral Singhal S, Rotman SR, Gaidhane M, Kahaleh M (2013) Pancreatic fluid collection drainage by endoscopic ultrasound: an update. Clin Endosc 46(5):506–514CrossRefPubMedPubMedCentral
13.
go back to reference Baron TH (2007) Treatment of pancreatic pseudocysts, pancreatic necrosis, and pancreatic duct leaks. Gastrointest Endosc Clin N Am 17:559–579CrossRefPubMed Baron TH (2007) Treatment of pancreatic pseudocysts, pancreatic necrosis, and pancreatic duct leaks. Gastrointest Endosc Clin N Am 17:559–579CrossRefPubMed
14.
go back to reference Yin WY (2005) The role of surgery in pancreatic pseudocyst. Hepatogastroenterology 52:1266–1273PubMed Yin WY (2005) The role of surgery in pancreatic pseudocyst. Hepatogastroenterology 52:1266–1273PubMed
15.
go back to reference Puri R, Mishra SR, Thandassery RB, Sud R, Eloubeidi MA (2012) Outcome and complications of endoscopic ultrasound guided pancreatic pseudocyst drainage using combined endoprosthesis and naso-cystic drain. J Gastroenterol Hepatol 27:722–727CrossRefPubMed Puri R, Mishra SR, Thandassery RB, Sud R, Eloubeidi MA (2012) Outcome and complications of endoscopic ultrasound guided pancreatic pseudocyst drainage using combined endoprosthesis and naso-cystic drain. J Gastroenterol Hepatol 27:722–727CrossRefPubMed
16.
go back to reference Baron TH, Harewood GC, Morgan DE, Yates MR (2002) Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 56:7–17CrossRefPubMed Baron TH, Harewood GC, Morgan DE, Yates MR (2002) Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 56:7–17CrossRefPubMed
17.
go back to reference Hookey LC, Debroux S, Delhaye M, Arvanitakis M, Le Moine O, Devière J (2006) Endoscopic drainage of pancreatic fluid collections in 116 patients: a comparison of etiologies, drainage techniques, and outcomes. Gastrointest Endosc 63:635–643CrossRefPubMed Hookey LC, Debroux S, Delhaye M, Arvanitakis M, Le Moine O, Devière J (2006) Endoscopic drainage of pancreatic fluid collections in 116 patients: a comparison of etiologies, drainage techniques, and outcomes. Gastrointest Endosc 63:635–643CrossRefPubMed
18.
go back to reference Varadarajulu S, Bang JY, Phadnis MA, Christein JD, Wilcox CM (2011) Endoscopic transmural drainage of peripancreatic fluid collections: outcomes and predictors of treatment success in 211 consecutive patients. J Gastrointest Surg 15:2080–2088CrossRefPubMed Varadarajulu S, Bang JY, Phadnis MA, Christein JD, Wilcox CM (2011) Endoscopic transmural drainage of peripancreatic fluid collections: outcomes and predictors of treatment success in 211 consecutive patients. J Gastrointest Surg 15:2080–2088CrossRefPubMed
19.
go back to reference Siddiqui A, DeWitt JM, Strongin A, Singh H, Jordan S, Loren DE, Kowalski T, Eloubeidi MA (2013) Outcomes of EUS-guided drainage of debris-containing pancreatic pseudocysts by using combined endoprosthesis and a nasocystic drain. Gastrointest Endosc 78(4):589–595CrossRefPubMed Siddiqui A, DeWitt JM, Strongin A, Singh H, Jordan S, Loren DE, Kowalski T, Eloubeidi MA (2013) Outcomes of EUS-guided drainage of debris-containing pancreatic pseudocysts by using combined endoprosthesis and a nasocystic drain. Gastrointest Endosc 78(4):589–595CrossRefPubMed
20.
go back to reference Itoi T, Binmoeller KF, Shah J, Sofuni A, Itokawa F, Kurihara T, Tsuchiya T, Ishii K, Tsuji Shujiro, Ikeuchi N, Moriyasu F (2012) Clinical evaluation of a novel lumen-apposing metal stent for endosonography-guided pancreatic pseudocyst and gallbladder drainage (with videos). Gastrointest Endosc 75(4):870–876CrossRefPubMed Itoi T, Binmoeller KF, Shah J, Sofuni A, Itokawa F, Kurihara T, Tsuchiya T, Ishii K, Tsuji Shujiro, Ikeuchi N, Moriyasu F (2012) Clinical evaluation of a novel lumen-apposing metal stent for endosonography-guided pancreatic pseudocyst and gallbladder drainage (with videos). Gastrointest Endosc 75(4):870–876CrossRefPubMed
21.
go back to reference Rische S, Riecken B, Degenkolb J, Kayser T, Caca K (2013) Transmural endoscopic necrosectomy of infected pancreatic necroses and drainage of infected pseudocysts: a tailored approach. Scand J Gastroenterol 48(2):231–240CrossRefPubMed Rische S, Riecken B, Degenkolb J, Kayser T, Caca K (2013) Transmural endoscopic necrosectomy of infected pancreatic necroses and drainage of infected pseudocysts: a tailored approach. Scand J Gastroenterol 48(2):231–240CrossRefPubMed
22.
go back to reference Talreja JP, Shami VM, Ku J, Morris TD, Ellen K, Kahaleh M (2008) Transenteric drainage of pancreatic fluid collections with fully covered self-expanding metallic stents (with video). Gastrointest Endosc 68:1199–1203CrossRefPubMed Talreja JP, Shami VM, Ku J, Morris TD, Ellen K, Kahaleh M (2008) Transenteric drainage of pancreatic fluid collections with fully covered self-expanding metallic stents (with video). Gastrointest Endosc 68:1199–1203CrossRefPubMed
23.
go back to reference Belle S, Collet P, Post S, Kaehler G (2010) Temporary cystogastrostomy with self-expanding metallic stents for pancreatic necrosis. Endoscopy 42:493–495CrossRefPubMed Belle S, Collet P, Post S, Kaehler G (2010) Temporary cystogastrostomy with self-expanding metallic stents for pancreatic necrosis. Endoscopy 42:493–495CrossRefPubMed
24.
go back to reference Ang TL, Eu Kwek AB, Fock KM, Teo EK (2014) Endoscopic ultrasound-guided insertion of a large diameter fully covered self-expandable metallic stent as rescue therapy for recurrent infected walled off pancreatic necrosis after surgical necrosectomy. Endosc Ultrasound 3:245–248CrossRefPubMedPubMedCentral Ang TL, Eu Kwek AB, Fock KM, Teo EK (2014) Endoscopic ultrasound-guided insertion of a large diameter fully covered self-expandable metallic stent as rescue therapy for recurrent infected walled off pancreatic necrosis after surgical necrosectomy. Endosc Ultrasound 3:245–248CrossRefPubMedPubMedCentral
25.
go back to reference Wrobel PS, Kaplan J, Siddiqui AA (2014) A new lumen-apposing metal stent for endoscopic transluminal drainage of peripancreatic fluid collections. Endosc Ultrasound 3:203–204CrossRefPubMedPubMedCentral Wrobel PS, Kaplan J, Siddiqui AA (2014) A new lumen-apposing metal stent for endoscopic transluminal drainage of peripancreatic fluid collections. Endosc Ultrasound 3:203–204CrossRefPubMedPubMedCentral
26.
go back to reference Seifert H, Biermer M, Schmitt W, Jürgensen C, Will U, Gerlach R, Kreitmair C, Meining A, Wehrmann T, Rösch T (2009) Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study). Gut 58:1260–1266CrossRefPubMed Seifert H, Biermer M, Schmitt W, Jürgensen C, Will U, Gerlach R, Kreitmair C, Meining A, Wehrmann T, Rösch T (2009) Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study). Gut 58:1260–1266CrossRefPubMed
Metadata
Title
Risk factors for infection after endoscopic ultrasonography-guided drainage of specific types of pancreatic and peripancreatic fluid collections (with video)
Authors
Jintao Guo
Linlin Feng
Siyu Sun
Nan Ge
Xiang Liu
Sheng Wang
Guoxin Wang
Beibei Sun
Publication date
01-07-2016
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 7/2016
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-015-4557-3

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