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Published in: Surgical Endoscopy 7/2012

01-07-2012 | Dynamic Manuscript

Pylorus- and spleen-preserving total pancreatoduodenectomy with resection of both whole splenic vessels: feasibility and laparoscopic application to intraductal papillary mucin-producing tumors of the pancreas

Authors: Sung Hoon Choi, Ho Kyoung Hwang, Chang Moo Kang, Chang Ik Yoon, Woo Jung Lee

Published in: Surgical Endoscopy | Issue 7/2012

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Abstract

Background

Total pancreatectomy is recommended for intraductal papillary mucinous tumors with widespread involvement of the entire pancreas. Organ-preserving and minimally invasive surgery should be applied in benign and borderline pancreatic lesions.

Methods

Pylorus- and spleen-preserving total pancreatoduodenectomy (PpSpTPD) with segmental resection of both splenic vessels was attempted for five patients. The technique was based on the concepts of two surgical procedures: pylorus-preserving pancreatoduodenectomy and distal pancreatectomy with segmental resection of splenic vessels (“extended” Warshaw’s procedure).

Results

Three patients underwent laparoscopic-assisted PpSpTPD and two underwent open surgery. No mortality was noted. Short-term follow-up (median, 28 months) suggested that all patients tolerated the insulin therapy and showed relatively good nutritional status. Only minimal to moderate perigastric fundal varices were noted without gastrointestinal bleeding.

Conclusions

PpSpTPD with segmental resection of both splenic vessels is feasible and safe. Even a minimally invasive approach can be indicated in selected patients.
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Literature
1.
go back to reference Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S (2006) International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 6:17–32PubMedCrossRef Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S (2006) International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 6:17–32PubMedCrossRef
2.
go back to reference Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD (2004) Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 239:788–797 discussion 797–789PubMedCrossRef Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD (2004) Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 239:788–797 discussion 797–789PubMedCrossRef
3.
go back to reference Yang AD, Melstrom LG, Bentrem DJ, Ujiki MB, Wayne JD, Strouch M, Bell RH, Rao SM, Talamonti MS (2007) Outcomes after pancreatectomy for intraductal papillary mucinous neoplasms of the pancreas: an institutional experience. Surgery 142:529–534 discussion 534–527PubMedCrossRef Yang AD, Melstrom LG, Bentrem DJ, Ujiki MB, Wayne JD, Strouch M, Bell RH, Rao SM, Talamonti MS (2007) Outcomes after pancreatectomy for intraductal papillary mucinous neoplasms of the pancreas: an institutional experience. Surgery 142:529–534 discussion 534–527PubMedCrossRef
4.
go back to reference Maire F, Hammel P, Terris B, Paye F, Scoazec JY, Cellier C, Barthet M, O’Toole D, Rufat P, Partensky C, Cuillerier E, Levy P, Belghiti J, Ruszniewski P (2002) Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma. Gut 51:717–722PubMedCrossRef Maire F, Hammel P, Terris B, Paye F, Scoazec JY, Cellier C, Barthet M, O’Toole D, Rufat P, Partensky C, Cuillerier E, Levy P, Belghiti J, Ruszniewski P (2002) Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma. Gut 51:717–722PubMedCrossRef
5.
go back to reference Kim SC, Park KT, Lee YJ, Lee SS, Seo DW, Lee SK, Kim MH, Jang SJ, Byun JH, Han DJ (2008) Intraductal papillary mucinous neoplasm of the pancreas: clinical characteristics and treatment outcomes of 118 consecutive patients from a single center. J Hepatobiliary Pancreat Surg 15:183–188PubMedCrossRef Kim SC, Park KT, Lee YJ, Lee SS, Seo DW, Lee SK, Kim MH, Jang SJ, Byun JH, Han DJ (2008) Intraductal papillary mucinous neoplasm of the pancreas: clinical characteristics and treatment outcomes of 118 consecutive patients from a single center. J Hepatobiliary Pancreat Surg 15:183–188PubMedCrossRef
6.
go back to reference Winter JM, Cameron JL, Campbell KA, Arnold MA, Chang DC, Coleman J, Hodgin MB, Sauter PK, Hruban RH, Riall TS, Schulick RD, Choti MA, Lillemoe KD, Yeo CJ (2006) 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg 10:1199–1210 discussion1210–1191PubMedCrossRef Winter JM, Cameron JL, Campbell KA, Arnold MA, Chang DC, Coleman J, Hodgin MB, Sauter PK, Hruban RH, Riall TS, Schulick RD, Choti MA, Lillemoe KD, Yeo CJ (2006) 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg 10:1199–1210 discussion1210–1191PubMedCrossRef
7.
go back to reference Rodriguez JR, Madanat MG, Healy BC, Thayer SP, Warshaw AL, Fernandez-del Castillo C (2007) Distal pancreatectomy with splenic preservation revisited. Surgery 141:619–625PubMedCrossRef Rodriguez JR, Madanat MG, Healy BC, Thayer SP, Warshaw AL, Fernandez-del Castillo C (2007) Distal pancreatectomy with splenic preservation revisited. Surgery 141:619–625PubMedCrossRef
8.
go back to reference White SA, Sutton CD, Weymss-Holden S, Berry DP, Pollard C, Rees Y, Dennison AR (2000) The feasibility of spleen-preserving pancreatectomy for end-stage chronic pancreatitis. Am J Surg 179:294–297PubMedCrossRef White SA, Sutton CD, Weymss-Holden S, Berry DP, Pollard C, Rees Y, Dennison AR (2000) The feasibility of spleen-preserving pancreatectomy for end-stage chronic pancreatitis. Am J Surg 179:294–297PubMedCrossRef
9.
go back to reference Kang CM, Lee JM, Kim MW, Yoon DS, Park JS, Lee WJ (2011) Experiences in central pancreatectomy. Dig Surg 28:57–62PubMedCrossRef Kang CM, Lee JM, Kim MW, Yoon DS, Park JS, Lee WJ (2011) Experiences in central pancreatectomy. Dig Surg 28:57–62PubMedCrossRef
10.
go back to reference Hirono S, Tani M, Kawai M, Ina S, Nishioka R, Miyazawa M, Fujita Y, Uchiyama K, Yamaue H (2009) Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors. Arch Surg 144:345–349 discussion 349–350PubMedCrossRef Hirono S, Tani M, Kawai M, Ina S, Nishioka R, Miyazawa M, Fujita Y, Uchiyama K, Yamaue H (2009) Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors. Arch Surg 144:345–349 discussion 349–350PubMedCrossRef
11.
go back to reference Billings BJ, Christein JD, Harmsen WS, Harrington JR, Chari ST, Que FG, Farnell MB, Nagorney DM, Sarr MG (2005) Quality-of-life after total pancreatectomy: is it really that bad on long-term follow-up? J Gastrointest Surg 9:1059–1066 discussion 1066–1057PubMedCrossRef Billings BJ, Christein JD, Harmsen WS, Harrington JR, Chari ST, Que FG, Farnell MB, Nagorney DM, Sarr MG (2005) Quality-of-life after total pancreatectomy: is it really that bad on long-term follow-up? J Gastrointest Surg 9:1059–1066 discussion 1066–1057PubMedCrossRef
12.
go back to reference Sugiyama M, Atomi Y (2000) Pylorus-preserving total pancreatectomy for pancreatic cancer. World J Surg 24:66–70 discussion 70–61PubMedCrossRef Sugiyama M, Atomi Y (2000) Pylorus-preserving total pancreatectomy for pancreatic cancer. World J Surg 24:66–70 discussion 70–61PubMedCrossRef
13.
go back to reference Agnifili A, Marino M, Verzaro R, Carducci G, Mancini E, Ibi I, Gianfelice F, Poccia G, De Bernardinis G (1997) Pylorus-preserving pancreatoduodenectomy allows a better maintenance of glucose homeostasis. Minerva Gastroenterol Dietol 43:135–142PubMed Agnifili A, Marino M, Verzaro R, Carducci G, Mancini E, Ibi I, Gianfelice F, Poccia G, De Bernardinis G (1997) Pylorus-preserving pancreatoduodenectomy allows a better maintenance of glucose homeostasis. Minerva Gastroenterol Dietol 43:135–142PubMed
14.
go back to reference Kozuschek W, Reith HB, Waleczek H, Haarmann W, Edelmann M, Sonntag D (1994) A comparison of long term results of the standard Whipple procedure and the pylorus preserving pancreatoduodenectomy. J Am Coll Surg 178:443–453PubMed Kozuschek W, Reith HB, Waleczek H, Haarmann W, Edelmann M, Sonntag D (1994) A comparison of long term results of the standard Whipple procedure and the pylorus preserving pancreatoduodenectomy. J Am Coll Surg 178:443–453PubMed
15.
go back to reference Naito H, Sasaki I, Takahashi M, Rahman MM, Matsuno S (1992) An experimental study on the gastric acid and gut hormone secretion after pylorus preserving duodenectomy in dogs. Gastroenterol Jpn 27:317–326PubMed Naito H, Sasaki I, Takahashi M, Rahman MM, Matsuno S (1992) An experimental study on the gastric acid and gut hormone secretion after pylorus preserving duodenectomy in dogs. Gastroenterol Jpn 27:317–326PubMed
16.
go back to reference Fatouros M, Bourantas K, Bairaktari E, Elisaf M, Tsolas O, Cassioumis D (1995) Role of the spleen in lipid metabolism. Br J Surg 82:1675–1677PubMedCrossRef Fatouros M, Bourantas K, Bairaktari E, Elisaf M, Tsolas O, Cassioumis D (1995) Role of the spleen in lipid metabolism. Br J Surg 82:1675–1677PubMedCrossRef
17.
go back to reference Robinette CD, Fraumeni JF Jr (1977) Splenectomy and subsequent mortality in veterans of the 1939–1945 war. Lancet 2:127–129PubMedCrossRef Robinette CD, Fraumeni JF Jr (1977) Splenectomy and subsequent mortality in veterans of the 19391945 war. Lancet 2:127–129PubMedCrossRef
18.
go back to reference Linet MS, Nyren O, Gridley G, Mellemkjaer L, McLaughlin JK, Olsen JH, Adami HO, Fraumeni JF Jr (1996) Risk of cancer following splenectomy. Int J Cancer 66:611–616PubMedCrossRef Linet MS, Nyren O, Gridley G, Mellemkjaer L, McLaughlin JK, Olsen JH, Adami HO, Fraumeni JF Jr (1996) Risk of cancer following splenectomy. Int J Cancer 66:611–616PubMedCrossRef
19.
go back to reference Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P, Fernandez-del Castillo C (2007) Middle pancreatectomy: indications, short- and long-term operative outcomes. Ann Surg 246:69–76PubMedCrossRef Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P, Fernandez-del Castillo C (2007) Middle pancreatectomy: indications, short- and long-term operative outcomes. Ann Surg 246:69–76PubMedCrossRef
20.
go back to reference Sa Cunha A, Rault A, Beau C, Laurent C, Collet D, Masson B (2008) A single-institution prospective study of laparoscopic pancreatic resection. Arch Surg 143:289–295 discussion 295PubMedCrossRef Sa Cunha A, Rault A, Beau C, Laurent C, Collet D, Masson B (2008) A single-institution prospective study of laparoscopic pancreatic resection. Arch Surg 143:289–295 discussion 295PubMedCrossRef
21.
go back to reference Kimura Y, Hirata K, Mukaiya M, Mizuguchi T, Koito K, Katsuramaki T (2005) Hand-assisted laparoscopic pylorus-preserving pancreaticoduodenectomy for pancreas head disease. Am J Surg 189:734–737PubMedCrossRef Kimura Y, Hirata K, Mukaiya M, Mizuguchi T, Koito K, Katsuramaki T (2005) Hand-assisted laparoscopic pylorus-preserving pancreaticoduodenectomy for pancreas head disease. Am J Surg 189:734–737PubMedCrossRef
22.
go back to reference Casadei R, Marchegiani G, Laterza M, Ricci C, Marrano N, Margiotta A, Minni F (2009) Total pancreatectomy: doing it with a mini-invasive approach. JOP 10:328–331PubMed Casadei R, Marchegiani G, Laterza M, Ricci C, Marrano N, Margiotta A, Minni F (2009) Total pancreatectomy: doing it with a mini-invasive approach. JOP 10:328–331PubMed
23.
go back to reference Jacobs JE, Birnbaum BA, Shapiro MA, Langlotz CP, Slosman F, Rubesin SE, Horii SC (1998) Diagnostic criteria for fatty infiltration of the liver on contrast-enhanced helical CT. AJR Am J Roentgenol 171:659–664PubMed Jacobs JE, Birnbaum BA, Shapiro MA, Langlotz CP, Slosman F, Rubesin SE, Horii SC (1998) Diagnostic criteria for fatty infiltration of the liver on contrast-enhanced helical CT. AJR Am J Roentgenol 171:659–664PubMed
Metadata
Title
Pylorus- and spleen-preserving total pancreatoduodenectomy with resection of both whole splenic vessels: feasibility and laparoscopic application to intraductal papillary mucin-producing tumors of the pancreas
Authors
Sung Hoon Choi
Ho Kyoung Hwang
Chang Moo Kang
Chang Ik Yoon
Woo Jung Lee
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 7/2012
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-011-2113-3

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