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Published in: Surgical Endoscopy 6/2012

01-06-2012

What is the best reconstruction method after distal gastrectomy for gastric cancer?

Authors: Moon-Soo Lee, Sang-Hoon Ahn, Ju-Hee Lee, Do Joong Park, Hyuk-Joon Lee, Hyung-Ho Kim, Han-Kwang Yang, Nayoung Kim, Won Woo Lee

Published in: Surgical Endoscopy | Issue 6/2012

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Abstract

Background

We performed this prospective randomized study to evaluate what is the best reconstruction method after distal gastrectomy for gastric cancer.

Methods

One hundred fifty-nine patients who underwent laparoscopy-assisted or open gastrectomy for gastric cancer were analyzed from March 2006 to August 2007. Billroth I (B-I) anastomosis, Billroth II (B-II) with Braun anastomosis, and Roux-en-Y (R-Y) anastomosis were applied randomly. Additionally, the patients were divided into two groups based on treatment type: laparoscopic and open operation. Endoscopy and hepatobiliary scans were performed to investigate gastric stasis and enterogastric reflux. The Gastrointestinal Quality of Life Index (GIQLI) was used to evaluate postoperative quality of life, and the hematologic test was used to assess nutritional aspect.

Results

Endoscopy revealed that reflux after the R-Y anastomosis procedure was significantly less frequent than after the other anastomosis types at 12 months. Comparison of the GIQLI and the nutritional parameters between the reconstruction types revealed that there were no differences, but a significantly higher GIQLI score was observed in the laparoscopic group immediately following the procedure (P = 0.042).

Conclusions

R-Y anastomosis is superior to B-I and B-II with Braun anastomosis in terms of frequency of bile reflux, despite the fact that there is no difference in the postoperative quality-of-life index and nutritional status between reconstructive procedures. The laparoscopic approach is the better option than open surgery in terms of QOL in the immediate postoperative period.
Literature
2.
go back to reference Lee SI, Choi YS, Park DJ, Kim HH, Yang HK, Kim MC (2006) Comparative study of laparoscopy-assisted distal gastrectomy and open distal gastrectomy. J Am Coll Surg 202(6):874–880PubMedCrossRef Lee SI, Choi YS, Park DJ, Kim HH, Yang HK, Kim MC (2006) Comparative study of laparoscopy-assisted distal gastrectomy and open distal gastrectomy. J Am Coll Surg 202(6):874–880PubMedCrossRef
3.
go back to reference Svensson JO (1983) Duodenogastric reflux after gastric surgery. Scand J Gastroenterol 18(6):729–734PubMedCrossRef Svensson JO (1983) Duodenogastric reflux after gastric surgery. Scand J Gastroenterol 18(6):729–734PubMedCrossRef
4.
go back to reference Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma–2nd English edn. Gastric Cancer 1(1):10–24PubMedCrossRef Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma–2nd English edn. Gastric Cancer 1(1):10–24PubMedCrossRef
5.
go back to reference Kubo M, Sasako M, Gotoda T, Ono H, Fujishiro M, Saito D, Sano T, Katai H (2002) Endoscopic evaluation of the remnant stomach after gastrectomy: proposal for a new classification. Gastric Cancer 5(2):83–89PubMedCrossRef Kubo M, Sasako M, Gotoda T, Ono H, Fujishiro M, Saito D, Sano T, Katai H (2002) Endoscopic evaluation of the remnant stomach after gastrectomy: proposal for a new classification. Gastric Cancer 5(2):83–89PubMedCrossRef
6.
go back to reference Miwa H, Yokoyama T, Hori K, Sakagami T, Oshima T, Tomita T, Fujiwara Y, Saita H, Oqawa H, Nakamura Y, Kishi K, Murayama Y, Hayashi E, Kobayashi K, Tano N, Matsushita K, Kawamoto H, Sawada Y, Ohkawa A, Arai E, Nagao K, Hamamoto N, Sugiyasu Y, Sugimoto K, Hara H, Tanimura M, Honda Y, Isozaki K, Noda S, Kubota S, Himeno S (2008) Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: a validation study in a cohort of Japanese endoscopists. Dis Esophagus 21(4):355–363PubMedCrossRef Miwa H, Yokoyama T, Hori K, Sakagami T, Oshima T, Tomita T, Fujiwara Y, Saita H, Oqawa H, Nakamura Y, Kishi K, Murayama Y, Hayashi E, Kobayashi K, Tano N, Matsushita K, Kawamoto H, Sawada Y, Ohkawa A, Arai E, Nagao K, Hamamoto N, Sugiyasu Y, Sugimoto K, Hara H, Tanimura M, Honda Y, Isozaki K, Noda S, Kubota S, Himeno S (2008) Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: a validation study in a cohort of Japanese endoscopists. Dis Esophagus 21(4):355–363PubMedCrossRef
7.
go back to reference Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM, Schmulling C, Neugebauer E, Troidl H (1995) Gastrointestinal Quality of Life Index: development, validation and application of a new instrument. Br J Surg 82(2):216–222PubMedCrossRef Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM, Schmulling C, Neugebauer E, Troidl H (1995) Gastrointestinal Quality of Life Index: development, validation and application of a new instrument. Br J Surg 82(2):216–222PubMedCrossRef
8.
go back to reference Osugi H, Fukuhara K, Takada N, Takemura M, Kinoshita H (2004) Reconstructive procedure after distal gastrectomy to prevent remnant gastritis. Hepatogastroenterology 51(58):1215–1218PubMed Osugi H, Fukuhara K, Takada N, Takemura M, Kinoshita H (2004) Reconstructive procedure after distal gastrectomy to prevent remnant gastritis. Hepatogastroenterology 51(58):1215–1218PubMed
9.
go back to reference Sato T, Miwa K, Sahara H, Segawa M, Hattori T (2002) The sequential model of Barrett’s esophagus and adenocarcinoma induced by duodeno-esophageal reflux without exogenous carcinogens. Anticancer Res 22(1A):39–44PubMed Sato T, Miwa K, Sahara H, Segawa M, Hattori T (2002) The sequential model of Barrett’s esophagus and adenocarcinoma induced by duodeno-esophageal reflux without exogenous carcinogens. Anticancer Res 22(1A):39–44PubMed
10.
go back to reference Werscher GJ, Hinder RA, Smyrk T, Perdikis G, Adrian TE, Profanter C (1999) Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux. Dig Dis Sci 44(6):1132–1135CrossRef Werscher GJ, Hinder RA, Smyrk T, Perdikis G, Adrian TE, Profanter C (1999) Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux. Dig Dis Sci 44(6):1132–1135CrossRef
11.
go back to reference Goldstein SR, Yang GY, Curtis SK, Reuhl KR, Liu BC, Mirvish SS, Newmark HL, Yang CS (1997) Development of esophageal metaplasia and adenocarcinoma in rat surgical model without the use of a carcinogen. Carcinogenesis 18(11):2265–2270PubMedCrossRef Goldstein SR, Yang GY, Curtis SK, Reuhl KR, Liu BC, Mirvish SS, Newmark HL, Yang CS (1997) Development of esophageal metaplasia and adenocarcinoma in rat surgical model without the use of a carcinogen. Carcinogenesis 18(11):2265–2270PubMedCrossRef
12.
go back to reference Lillimoe KP, Johnson LF, Harmon JW (1982) Role of the components of the gastroduodenal contents in experimental acid esophagitis. Surgery 92(2):276–284 Lillimoe KP, Johnson LF, Harmon JW (1982) Role of the components of the gastroduodenal contents in experimental acid esophagitis. Surgery 92(2):276–284
13.
go back to reference Shinoto K, Ochiai T, Suzuki T, Okazumi S, Ozaki M (2003) Effectiveness of Roux-en-Y reconstruction after distal gastrectomy based on an assessment of biliary kinetics. Surg Today 33(3):169–177PubMedCrossRef Shinoto K, Ochiai T, Suzuki T, Okazumi S, Ozaki M (2003) Effectiveness of Roux-en-Y reconstruction after distal gastrectomy based on an assessment of biliary kinetics. Surg Today 33(3):169–177PubMedCrossRef
14.
go back to reference Vogel SB, Drane WE, Woodwar ER (1994) Clinical and radionuclide evaluation of bile diversion by Braun enteroenterostomy: prevention and treatment of alkine reflux gastritis. an alternative to Roux-en-Y diversion. Ann Surg 219(5):458–465PubMedCrossRef Vogel SB, Drane WE, Woodwar ER (1994) Clinical and radionuclide evaluation of bile diversion by Braun enteroenterostomy: prevention and treatment of alkine reflux gastritis. an alternative to Roux-en-Y diversion. Ann Surg 219(5):458–465PubMedCrossRef
15.
go back to reference Chan DC, Fan YM, Lin CK, Chen CJ, Chao YC (2007) Roux-en-Y reconstruction after distal gastrectomy to reduce enterogastric reflux and Helicobacter pylori infection. J Gastrointest Surg 11(12):1732–1740PubMedCrossRef Chan DC, Fan YM, Lin CK, Chen CJ, Chao YC (2007) Roux-en-Y reconstruction after distal gastrectomy to reduce enterogastric reflux and Helicobacter pylori infection. J Gastrointest Surg 11(12):1732–1740PubMedCrossRef
16.
go back to reference Fukuhara K, Osugi H, Takada N, Takemura M, Higashino M, Kinoshita H (2002) Reconstructive procedure after distal gastrectomy for gastric cancer that best prevents duodenogastroesophagel reflux. World J Surg 26(12):1452–1457PubMedCrossRef Fukuhara K, Osugi H, Takada N, Takemura M, Higashino M, Kinoshita H (2002) Reconstructive procedure after distal gastrectomy for gastric cancer that best prevents duodenogastroesophagel reflux. World J Surg 26(12):1452–1457PubMedCrossRef
17.
go back to reference Kojima K, Yamada H, Inokuchi M, Kawano T, Sugihara K (2008) A comparison of Roux-en-Y and Billroth-I reconstruction after laparoscopy-assisted distal gastrectomy. Ann Surg 247(6):962–967PubMedCrossRef Kojima K, Yamada H, Inokuchi M, Kawano T, Sugihara K (2008) A comparison of Roux-en-Y and Billroth-I reconstruction after laparoscopy-assisted distal gastrectomy. Ann Surg 247(6):962–967PubMedCrossRef
18.
go back to reference Hoya Y, Mitsumori N, Yanaga K (2009) The advantages and disadvantages of a Roux-en-Y reconstruction after a distal gastrectomy for gastric cancer. Surg Today 39(8):647–651PubMedCrossRef Hoya Y, Mitsumori N, Yanaga K (2009) The advantages and disadvantages of a Roux-en-Y reconstruction after a distal gastrectomy for gastric cancer. Surg Today 39(8):647–651PubMedCrossRef
19.
go back to reference Namikawa T, Kitagawa H, Okabayashi T, Sugimoto T, Kobayashi M, Hanazaki K (2010) Roux-en-Y reconstruction is superior to Billroth I reconstruction in reducing reflux esophagitis after distal gastrectomy: special relationship with the angle of His. World J Surg 34(5):1022–1027PubMedCrossRef Namikawa T, Kitagawa H, Okabayashi T, Sugimoto T, Kobayashi M, Hanazaki K (2010) Roux-en-Y reconstruction is superior to Billroth I reconstruction in reducing reflux esophagitis after distal gastrectomy: special relationship with the angle of His. World J Surg 34(5):1022–1027PubMedCrossRef
20.
go back to reference Gustavsson S, Ilstrup DM, Morrison P, Kelly KA (1988) Roux-Y stasis syndrome after gastrectomy. Am J Surg 155(3):490–494PubMedCrossRef Gustavsson S, Ilstrup DM, Morrison P, Kelly KA (1988) Roux-Y stasis syndrome after gastrectomy. Am J Surg 155(3):490–494PubMedCrossRef
21.
go back to reference Hintze RE, Adler A, Veltzke W, Abou-Rebyeh H (1997) Endoscopic access to the papilla of Vater for endoscopic retrograde cholangiopancreatography in patients with Billroth II or Roux-en-Y gastrojejunostomy. Endoscopy 29(2):69–73PubMedCrossRef Hintze RE, Adler A, Veltzke W, Abou-Rebyeh H (1997) Endoscopic access to the papilla of Vater for endoscopic retrograde cholangiopancreatography in patients with Billroth II or Roux-en-Y gastrojejunostomy. Endoscopy 29(2):69–73PubMedCrossRef
22.
go back to reference Iwamoto S, Ryozawa S, Yamamoto H, Taba K, Ishigaki N, Harano M, Iwano H, Sakaida I (2010) Double balloon endoscope facilitates endoscopic retrograde cholangiopancreatography in Roux-en-Y anastomosis patients. Dig Endosc 22(1):64–68PubMedCrossRef Iwamoto S, Ryozawa S, Yamamoto H, Taba K, Ishigaki N, Harano M, Iwano H, Sakaida I (2010) Double balloon endoscope facilitates endoscopic retrograde cholangiopancreatography in Roux-en-Y anastomosis patients. Dig Endosc 22(1):64–68PubMedCrossRef
23.
go back to reference Kim BJ, O’Connell T (1999) Gastroduodenostomy after gastric resection for cancer. Am Surg 65(10):905–907PubMed Kim BJ, O’Connell T (1999) Gastroduodenostomy after gastric resection for cancer. Am Surg 65(10):905–907PubMed
24.
go back to reference Montesani C, D’Amato A, Santella S, Pronio A, Giovannini C, Cristaldi M, Ribotta G (2002) Billroth I versus Billroth II versus Roux-en-Y after subtotal gastrectomy. Prospective randomized study. Hepatogastroenterology 49(47):1469–1473PubMed Montesani C, D’Amato A, Santella S, Pronio A, Giovannini C, Cristaldi M, Ribotta G (2002) Billroth I versus Billroth II versus Roux-en-Y after subtotal gastrectomy. Prospective randomized study. Hepatogastroenterology 49(47):1469–1473PubMed
25.
go back to reference Johnsson F, Joelsson B, Gudmundsson K, Greiff L (1987) Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease. Scand J Gastroenterol 22(6):714–718PubMedCrossRef Johnsson F, Joelsson B, Gudmundsson K, Greiff L (1987) Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease. Scand J Gastroenterol 22(6):714–718PubMedCrossRef
26.
go back to reference Shiraishi N, Yasuda K, Kitano S (2006) Laparoscopic gastrectomy with lymph node dissection for gastric cancer. Gastric Cancer 9(3):167–176PubMedCrossRef Shiraishi N, Yasuda K, Kitano S (2006) Laparoscopic gastrectomy with lymph node dissection for gastric cancer. Gastric Cancer 9(3):167–176PubMedCrossRef
27.
go back to reference Kitagawa Y, Kitano S, Kubota T, Kumai K, Otani Y, Saikawa Y, Yoshida M, Kitajima M (2005) Minimally invasive surgery for gastric cancer–toward a confluence of two major streams: a review. Gastric Cancer 8(2):103–110PubMedCrossRef Kitagawa Y, Kitano S, Kubota T, Kumai K, Otani Y, Saikawa Y, Yoshida M, Kitajima M (2005) Minimally invasive surgery for gastric cancer–toward a confluence of two major streams: a review. Gastric Cancer 8(2):103–110PubMedCrossRef
Metadata
Title
What is the best reconstruction method after distal gastrectomy for gastric cancer?
Authors
Moon-Soo Lee
Sang-Hoon Ahn
Ju-Hee Lee
Do Joong Park
Hyuk-Joon Lee
Hyung-Ho Kim
Han-Kwang Yang
Nayoung Kim
Won Woo Lee
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 6/2012
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-011-2064-8

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