Skip to main content
Top
Published in: Surgical Endoscopy 10/2010

01-10-2010

Clipless laparoscopic cholecystectomy using the Harmonic scalpel for cirrhotic patients: a prospective randomized study

Authors: Ayman El Nakeeb, Waleed Askar, Ramadan El Lithy, Mohamed Farid

Published in: Surgical Endoscopy | Issue 10/2010

Login to get access

Abstract

Background

Improved laparoscopic experiences have made laparoscopic cholecystectomy (LC) feasible options for cirrhotic patients. This study aimed to compare the traditional method for LC with LC using the Harmonic scalpel in terms of safety and efficacy for cirrhotic patients.

Methods

In this study, group A (60 patients) underwent LC by the traditional method (TM) with clipping of both the cystic duct and artery and dissection of the gallbladder by diathermy, and group B (60 patients) had LC performed using Harmonic scalpel (HS) closure and division of both the cystic duct and artery with dissection of the gallbladder by the HS. The perioperative data were recorded.

Results

The operation with the Harmonic scalpel was performed in less time than TM (45.17 ± 10.54 vs. 69.71 ± 13.01 min; p = 0.0001). The intraoperative blood loss was significantly more with TM (133 ± 131.13 l vs. 70.13 ± 80.79 ml; p = 0.002). The conversion rate was 5% with TM and 3.3% with HS (p = 0.65). The incidence of gallbladder peroration was lower in the HS group (10% vs. 18.3%; p = 0.03). Bile leak was encountered in 1.7% with HS and 3.3% with TM (p = 0.45). The visual analog scale (VAS) for pain with HS on postoperative day 1 was (3.07 ± 2.02 vs. 4.4 ± 2.11 (p = 0.001).

Conclusion

For cirrhotic patients, LC still is more complicated and difficult than for patients without cirrhosis. The Harmonic scalpel provides complete hemobiliary stasis and is a safe alternative to the standard clipping of the cystic duct and artery for cirrhotic patients. It offers a shorter operative duration and less blood loss.
Literature
1.
go back to reference Morino M, Cavuoti G, Miglietta C, Giraudo G, Simone P (2000) Laparoscopic cholecystectomy in cirrhosis: contraindication or privileged indication? Surg Laparosc Endosc Percutan Tech 10:360–363PubMed Morino M, Cavuoti G, Miglietta C, Giraudo G, Simone P (2000) Laparoscopic cholecystectomy in cirrhosis: contraindication or privileged indication? Surg Laparosc Endosc Percutan Tech 10:360–363PubMed
2.
go back to reference Poggio JL, Rowland CM, Gores GJ, Nagorney DM, Donohue JH (2000) A comparison of laparoscopic and open cholecystectomy in patients with compensated cirrhosis and symptomatic gallstone disease. Surgery 127:405–411CrossRefPubMed Poggio JL, Rowland CM, Gores GJ, Nagorney DM, Donohue JH (2000) A comparison of laparoscopic and open cholecystectomy in patients with compensated cirrhosis and symptomatic gallstone disease. Surgery 127:405–411CrossRefPubMed
3.
go back to reference Schesinger WH, Kurtin WE, Levine BA (1985) Cirrhosis and alcoholism as pathogenic factors in pigmented gallstones formation. Ann Surg 201:319–322CrossRef Schesinger WH, Kurtin WE, Levine BA (1985) Cirrhosis and alcoholism as pathogenic factors in pigmented gallstones formation. Ann Surg 201:319–322CrossRef
4.
go back to reference Puggioni A, Wong LL (2003) A metaanalysis of laparoscopic cholecystectomy in patients with cirrhosis. J Am Coll Surg 197:921–926CrossRefPubMed Puggioni A, Wong LL (2003) A metaanalysis of laparoscopic cholecystectomy in patients with cirrhosis. J Am Coll Surg 197:921–926CrossRefPubMed
5.
go back to reference Bloch RS, Allaben RD, Walt AJ (1985) Cholecystectomy in patients with cirrhosis: a surgical challenge. Arch Surg 120:669–672PubMed Bloch RS, Allaben RD, Walt AJ (1985) Cholecystectomy in patients with cirrhosis: a surgical challenge. Arch Surg 120:669–672PubMed
6.
go back to reference Angrisani L, Lorenzo M, Corcione F, Vincenti R (1997) Gallstones in cirrhotics revisited by a laparoscopic view. J Laparoendosc Adv Surg Tech A 7:213–220CrossRefPubMed Angrisani L, Lorenzo M, Corcione F, Vincenti R (1997) Gallstones in cirrhotics revisited by a laparoscopic view. J Laparoendosc Adv Surg Tech A 7:213–220CrossRefPubMed
7.
go back to reference El-Awadi S, El Nakeeb A, Youssef T, Fikry A, Abd El-Hamed TM, Ghazy H, Fouda E, Faried M (2009) Laparoscopic versus open cholecystectomy in cirrhotic patients: a prospective randomized study. Int J Surg 7:66–69CrossRefPubMed El-Awadi S, El Nakeeb A, Youssef T, Fikry A, Abd El-Hamed TM, Ghazy H, Fouda E, Faried M (2009) Laparoscopic versus open cholecystectomy in cirrhotic patients: a prospective randomized study. Int J Surg 7:66–69CrossRefPubMed
8.
go back to reference Delis S, Bakoyiannis A, Juan Madariage, Bramis J, Tassopoulos N, Dervenis C (2010) Laparoscopic cholecystectomy in cirrhotic patients: the value of MELD score and Child–Pugh classification in predicting outcome. Surg Endosc 24(2):407–412 Delis S, Bakoyiannis A, Juan Madariage, Bramis J, Tassopoulos N, Dervenis C (2010) Laparoscopic cholecystectomy in cirrhotic patients: the value of MELD score and Child–Pugh classification in predicting outcome. Surg Endosc 24(2):407–412
9.
10.
go back to reference Amaral JF (1994) The experimental development of an ultrasonically activated scalpel for laparoscopic use. Surg Laparosc Endosc 4:92–99PubMed Amaral JF (1994) The experimental development of an ultrasonically activated scalpel for laparoscopic use. Surg Laparosc Endosc 4:92–99PubMed
11.
go back to reference Kandil T, El Nakeeb A, El Hefnawy E (2010) Comparative study between clipless laparoscopic cholecystectomy by Harmonic scalpel versus conventional method: a prospective randomized study. J Gastrointest Surg 14:323–328CrossRefPubMed Kandil T, El Nakeeb A, El Hefnawy E (2010) Comparative study between clipless laparoscopic cholecystectomy by Harmonic scalpel versus conventional method: a prospective randomized study. J Gastrointest Surg 14:323–328CrossRefPubMed
12.
go back to reference Huscher CGS, Lirici MM, Di Paola M, Crafa F, Napolitano C, Mereu A, Recher A, Corradi A, Amini M (2003) Laparoscopic cholecystectomy by ultrasonic dissection without cystic duct and artery ligature. Surg Endosc 17:442–451CrossRefPubMed Huscher CGS, Lirici MM, Di Paola M, Crafa F, Napolitano C, Mereu A, Recher A, Corradi A, Amini M (2003) Laparoscopic cholecystectomy by ultrasonic dissection without cystic duct and artery ligature. Surg Endosc 17:442–451CrossRefPubMed
13.
go back to reference Westervalt J (2004) Clipless cholecystectomy: broadening the role of the Harmonic scalpel. JSLS 8:283–285 Westervalt J (2004) Clipless cholecystectomy: broadening the role of the Harmonic scalpel. JSLS 8:283–285
14.
go back to reference Janssen IMC, Swank DJ, Boonstra O, Knipscheer BC, Klinkenbijil JH, Goor HV (2003) Randomized clinical trial of ultrasonic versus electrocautery dissection of the gallbladder in laparoscopic cholecystectomy. Br J Surg 90:799–803CrossRefPubMed Janssen IMC, Swank DJ, Boonstra O, Knipscheer BC, Klinkenbijil JH, Goor HV (2003) Randomized clinical trial of ultrasonic versus electrocautery dissection of the gallbladder in laparoscopic cholecystectomy. Br J Surg 90:799–803CrossRefPubMed
15.
go back to reference Bessa SS, Al-Fayoumi TA, Katri KM, Awad AT (2008) Clipless laparoscopic cholecystectomy by ultrasonic dissection. J Laparoendosc Adv Surg Tech A 18:593–598CrossRefPubMed Bessa SS, Al-Fayoumi TA, Katri KM, Awad AT (2008) Clipless laparoscopic cholecystectomy by ultrasonic dissection. J Laparoendosc Adv Surg Tech A 18:593–598CrossRefPubMed
16.
go back to reference Huskisson EC (1974) Measurement of pain. Lancet 1127–1131 Huskisson EC (1974) Measurement of pain. Lancet 1127–1131
17.
go back to reference Aranha GV, Sontag SJ, Greenlee HB (1982) Cholecystectomy in cirrhotic patients: a formidable operation. Am J Surg 143:55–60CrossRefPubMed Aranha GV, Sontag SJ, Greenlee HB (1982) Cholecystectomy in cirrhotic patients: a formidable operation. Am J Surg 143:55–60CrossRefPubMed
18.
go back to reference Sirinek KR, Burk RR, Brown M, Levine BA (1987) Improving survival in patients with cirrhosis undergoing major abdominal operations. Arch Surg 122:271–273PubMed Sirinek KR, Burk RR, Brown M, Levine BA (1987) Improving survival in patients with cirrhosis undergoing major abdominal operations. Arch Surg 122:271–273PubMed
19.
go back to reference Schiff J, Misra G, Rendon J, Rothschild S, Schwaitzeberg (2005) Laparoscopic cholecystectomy in cirrhotic patients. Surg Endosc 19:1278–1281CrossRefPubMed Schiff J, Misra G, Rendon J, Rothschild S, Schwaitzeberg (2005) Laparoscopic cholecystectomy in cirrhotic patients. Surg Endosc 19:1278–1281CrossRefPubMed
20.
go back to reference Gossot D, Buess G, Cuschieri A, Leporte E, Lirici M, Marvik R, Meijer D, Melzer A, Schurr MO (1999) Ultrasonic dissection for endoscopic surgery. Surg Endosc 13:412–417CrossRefPubMed Gossot D, Buess G, Cuschieri A, Leporte E, Lirici M, Marvik R, Meijer D, Melzer A, Schurr MO (1999) Ultrasonic dissection for endoscopic surgery. Surg Endosc 13:412–417CrossRefPubMed
21.
go back to reference Cucinotta E, Lazzan S, Melita G (2003) Laparoscopic cholecystectomy in cirrhotic patients. Surg Endosc 17:1958–1960CrossRefPubMed Cucinotta E, Lazzan S, Melita G (2003) Laparoscopic cholecystectomy in cirrhotic patients. Surg Endosc 17:1958–1960CrossRefPubMed
22.
go back to reference Ji W, Li L-T, Wang Z-M, Quan Z-F, Chen X-R, Li J-S (2005) A randomized controlled trial of laparoscopic versus open cholecystectomy in patients with cirrhotic portal hypertensions. World J Gastroenterol 11:2513–2517PubMed Ji W, Li L-T, Wang Z-M, Quan Z-F, Chen X-R, Li J-S (2005) A randomized controlled trial of laparoscopic versus open cholecystectomy in patients with cirrhotic portal hypertensions. World J Gastroenterol 11:2513–2517PubMed
23.
go back to reference Fredman B, Jedeikin R, Olsfanger D, Flor P, Gruzman A (1994) Residual pneumoperitoneum: a cause of postoperative pain after laparoscopic cholecystectomy. Anesth Analg 79:152–154PubMed Fredman B, Jedeikin R, Olsfanger D, Flor P, Gruzman A (1994) Residual pneumoperitoneum: a cause of postoperative pain after laparoscopic cholecystectomy. Anesth Analg 79:152–154PubMed
24.
go back to reference Hanazaki K, Igarashi J, Sodeyama H, Matsuda Y (1999) Bile leakage resulting from clip displacement of the cystic duct stump: a potential pitfall of laparoscopic cholecystectomy. Surg Endosc 13:168–171CrossRefPubMed Hanazaki K, Igarashi J, Sodeyama H, Matsuda Y (1999) Bile leakage resulting from clip displacement of the cystic duct stump: a potential pitfall of laparoscopic cholecystectomy. Surg Endosc 13:168–171CrossRefPubMed
25.
go back to reference Nelson TM, Nakashima M, Mulvihill SJ (1992) How secure are laparoscopically placed clips? Arch Surg 127:718–720PubMed Nelson TM, Nakashima M, Mulvihill SJ (1992) How secure are laparoscopically placed clips? Arch Surg 127:718–720PubMed
26.
go back to reference McMahon AJ, Fullarton G, Baxter JN, O’Dwyer PJ (1995) Bile duct injury and bile leakage in laparoscopic cholecystectomy. Br J Surg 82:307–313CrossRefPubMed McMahon AJ, Fullarton G, Baxter JN, O’Dwyer PJ (1995) Bile duct injury and bile leakage in laparoscopic cholecystectomy. Br J Surg 82:307–313CrossRefPubMed
27.
go back to reference Reis LD (2000) Surgical clips incorporated into a duodenal ulcer: a rare complication after elective laparoscopic cholecystectomy. Endoscopy 32:S3CrossRefPubMed Reis LD (2000) Surgical clips incorporated into a duodenal ulcer: a rare complication after elective laparoscopic cholecystectomy. Endoscopy 32:S3CrossRefPubMed
28.
go back to reference Libermann MA, Howe S, Lane M (2000) Ondansetron versus placebo for prophylaxis of nausea and vomiting in patients undergoing ambulatory laparoscopic cholecystectomy. Am J Surg 179:60–62CrossRef Libermann MA, Howe S, Lane M (2000) Ondansetron versus placebo for prophylaxis of nausea and vomiting in patients undergoing ambulatory laparoscopic cholecystectomy. Am J Surg 179:60–62CrossRef
Metadata
Title
Clipless laparoscopic cholecystectomy using the Harmonic scalpel for cirrhotic patients: a prospective randomized study
Authors
Ayman El Nakeeb
Waleed Askar
Ramadan El Lithy
Mohamed Farid
Publication date
01-10-2010
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 10/2010
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-010-0999-9

Other articles of this Issue 10/2010

Surgical Endoscopy 10/2010 Go to the issue