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Journal of Cancer Research and Clinical Oncology

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01-08-2021 | Colon Cancer | Review – Cancer Research

Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?

Author: Abdul Arif Khan

Published in: Journal of Cancer Research and Clinical Oncology | Issue 8/2021

Abstract

Colorectal cancer is an important public health concern leading to significant cancer associate mortality. A vast majority of colon cancer arises from polyp which later follows adenoma, adenocarcinoma, and carcinoma sequence. This whole process takes several years to complete and recent genomic and proteomic technologies are identifying several targets involved in each step of polyp to carcinoma transformation in a large number of studies. Current text presents interaction network of targets involved in polyp to carcinoma transformation. In addition, important targets involved in each step according to network biological parameters are also presented. The functional overrepresentation analysis of each step targets and common top biological processes and pathways involved in carcinoma indicate several insights about this whole mechanism. Interaction networks indicate TP53, AKT1, GAPDH, INS, EGFR, and ALB as the most important targets commonly involved in polyp to carcinoma sequence. Though several important pathways are known to be involved in CRC, the central common involvement of PI3K-AKT indicates its potential for devising CRC management strategies. The common and central targets and pathways involved in polyp to carcinoma progression can shed light on its mechanism and potential management strategies. The data-driven approach aims to add valuable inputs to the mechanism of the years-long polyp-carcinoma sequence.

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Title: Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?
Author: Abdul Arif Khan
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Colon Cancer
Colon Cancer
Colorectal Cancer
Colorectal Cancer
Published in: Journal of Cancer Research and Clinical Oncology / Issue 8/2021
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-021-03685-5

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