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Journal of Cancer Research and Clinical Oncology

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01-06-2020 | Breast Cancer | Original Article – Cancer Research

Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort

Authors: Glauco Akelinghton Freire Vitiello, Nathalia de Sousa Pereira, Marla Karine Amarante, Bruna Karina Banin-Hirata, Clodoaldo Zago Campos, Karen Brajão de Oliveira, Roberta Losi-Guembarovski, Maria Angelica Ehara Watanabe

Published in: Journal of Cancer Research and Clinical Oncology | Issue 6/2020

Abstract

Purpose

APOBEC3A and APOBEC3B cytidine deaminases have been implicated in the pathogenesis of multiple cancers, including breast cancer (BC). A germline deletion linking APOBEC3A and APOBEC3B loci (A3A/B) has been associated with higher APOBEC-mediated mutational burden, but its association with BC risk have been controversial. Therefore, this study investigated the association between A3A/B and BC susceptibility and clinical presentation in a Brazilian cohort.

Methods

A3A/B deletion was evaluated through allele-specific PCR in 341 BC patients and 397 women without familial or personal history of neoplasia from Brazil and associations with susceptibility to BC subtypes were tested through age-adjusted logistic models while correlations with clinicopathological parameters were tested using Kendall’s tests.

Results

No association was found between A3A/B and BC susceptibility; however, in Luminal-A BCs, it was positively correlated with tumor size (Tau-c = 0.125) and Ki67 (Tau-c = 0.116) and negatively correlated with lymph node metastasis (LNM) (Tau-c = − 0.162). The negative association between A3A/B with LNM in Luminal-A BCs remained significant even after adjusting for tumor size and Ki67 in logistic models (OR = 0.22; p = 0.008).

Conclusion

These results show that although A3A/B may not modify BC susceptibility in Brazilian population, it may affect clinicopathological features in BC subtypes, promoting tumor cell proliferation while being negatively associated with LNM in Luminal-A BCs.

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Title: Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort
Authors: Glauco Akelinghton Freire Vitiello
Nathalia de Sousa Pereira
Marla Karine Amarante
Bruna Karina Banin-Hirata
Clodoaldo Zago Campos
Karen Brajão de Oliveira
Roberta Losi-Guembarovski
Maria Angelica Ehara Watanabe
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Breast Cancer
Breast Cancer
Published in: Journal of Cancer Research and Clinical Oncology / Issue 6/2020
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03208-8

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Conclusion

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