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Journal of Cancer Research and Clinical Oncology

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01-06-2020 | Radionuclide Therapy | Review – Clinical Oncology

The efficacy of ¹⁷⁷Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours: a systematic review and meta-analysis

Authors: Jie Zhang, Qi Song, Liang Cai, Ying Xie, Yue Chen

Published in: Journal of Cancer Research and Clinical Oncology | Issue 6/2020

Abstract

Purpose

To evaluate the efficacy of ¹⁷⁷Lu-DOTA0-Tyr3-octreotate (¹⁷⁷Lu-DOTATATE) radionuclide therapy in patients with inoperable or metastatic neuroendocrine tumours (NETs), (PROSPERO ID CRD42019130755).

Methods

All published clinical studies of NETs treated with ¹⁷⁷Lu-DOTATATE were identified based on systematic searches in the PubMed, EMBASE, Cochrane Library, Web of Science and ClinicalTrials.gov databases up to January 2019. Among these studies, only the reports evaluated with the “Response Evaluation Criteria in Solid Tumours (RECIST)” or “Southwest Oncology Group (SWOG)” criteria or both were included. We analysed the disease response rate (DRR) and disease control rate (DCR) of each group to evaluate the efficacy of ¹⁷⁷Lu-DOTATATE.

Results

Fifteen studies were selected from 715 references. The pooled effect in the RECIST group (13 studies) was 27.58% (95% confidence interval (CI) 21.03–35.27%) for the DRR and 79.14% (95% CI 75.83–82.1%) for the DCR. In the SWOG criteria group (7 studies), the pooled effect was 20.59% (95% CI 10.89–35.51%) for the DRR and 78.28% (95% CI 74.39–81.72%) for the DCR. Therefore, the RECIST and SWOG groups showed similar DRRs and DCRs after¹⁷⁷Lu-DOTATATE treatment, indicating that ¹⁷⁷Lu-DOTATATE treatment has excellent efficacy with a control rate of approximately 78–79%. Moreover, adverse effects of ¹⁷⁷Lu-DOTATATE were minimal, including fatigue, nausea, vomiting and hormonal disorders.

Conclusions

For patients with inoperable or metastatic NETs, ¹⁷⁷Lu-DOTATATE is an effective treatment with minimal side effects.

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Title: The efficacy of 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours: a systematic review and meta-analysis
Authors: Jie Zhang
Qi Song
Liang Cai
Ying Xie
Yue Chen
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keyword: Radionuclide Therapy
Published in: Journal of Cancer Research and Clinical Oncology / Issue 6/2020
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-020-03181-2

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Purpose

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Conclusions

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