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Journal of Cancer Research and Clinical Oncology

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01-11-2018 | Original Article – Cancer Research

Clinical utility of assessing PTEN and ERG protein expression in prostate cancer patients: a proposed method for risk stratification

Authors: Tarek A. Bismar, Samar Hegazy, Zhaoyong Feng, Darryl Yu, Bryan Donnelly, Nallasivam Palanisamy, Bruce J. Trock

Published in: Journal of Cancer Research and Clinical Oncology | Issue 11/2018

Abstract

Objectives

To assess the prognostic value of ERG and PTEN protein expression as two of the most common genetic aberration in men with prostate cancer managed non-surgically by androgen deprivation therapy (ADT).

Materials and methods

463 tumor samples were assessed by double immunohistochemistry stains for ERG and PTEN and data correlated with clinical pathological features including, Gleason score, patients’ outcome and ADT.

Results

ERG expression and PTEN protein loss were present in 28.2% and 38% of total patients respectively. There was a significant interplay between ERG and PTEN expression with 21.8% PTEN negative tumors being ERG positive (p < 0.001). Both ERG and PTEN showed significant association with lethal disease in all patients and those treated with prior ADT representing castrate-resistant disease. However, only PTEN remained significant in multivariable proportional hazards regression analysis, when including Gleason score and patients’ age. Depending on patient’s subgroup, intact positive PTEN intensity showed better cancer-specific survival with HR ranging from 0.25 to 0.4 compared to tumors with loss of PTEN expression. Assessing combined marker status, patients with decreased PTEN intensity without ERG positivity showed the worst clinical outcome compared to those with no PTEN loss and no ERG expression, where they had best clinical outcome. Patients with ERG expression with or without PTEN loss showed intermediate risk in relation to lethal disease.

Conclusion

This study confirms a significant prognostic role for assessing ERG and PTEN in men with prostate cancer. It supports a role for utilizing combined ERG/PTEN status clinically and prospectively for stratifying PCa patients into different prognostic groups.

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Title: Clinical utility of assessing PTEN and ERG protein expression in prostate cancer patients: a proposed method for risk stratification
Authors: Tarek A. Bismar
Samar Hegazy
Zhaoyong Feng
Darryl Yu
Bryan Donnelly
Nallasivam Palanisamy
Bruce J. Trock
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 11/2018
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2730-5

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Clinical utility of assessing PTEN and ERG protein expression in prostate cancer patients: a proposed method for risk stratification

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Objectives

Materials and methods

Results

Conclusion

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