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Journal of Cancer Research and Clinical Oncology

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01-09-2016 | Original Article – Cancer Research

Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma

Authors: Andras Javorhazy, Nelli Farkas, Tamas Beothe, Csaba Pusztai, Arpad Szanto, Gyula Kovacs

Published in: Journal of Cancer Research and Clinical Oncology | Issue 9/2016

Abstract

Purpose

In spite of early detection of conventional renal cell carcinoma (RCC) by widespread use of abdominal imaging, approximately 10–15 % of patients will die due to disease. The aim of this study was to identify new biomarkers predicting the postoperative progression of conventional RCC.

Methods

Tissue multiarrays (TMA) of conventional RCC from a cohort of 486 patients were analysed by immunohistochemistry for expression of the transmembrane protein TMEM27, which was identified as a candidate biomarker by Affymetrix U133 Plus 2.0 array. Univariate and multivariate Cox regression models were addressed to assess cancer-specific survival in association with clinicopathological variables and TMEM27 expression. Cancer-specific survival time was estimated with Kaplan–Meier analysis, and the comparison of survival curves was made with the log-rank test.

Results

The Kaplan–Meier survival analysis indicated a poor disease-specific survival rates for tumours without TMEM27 staining. Univariate analysis revealed an association of patient survival with T stadium, grade, stage and size of tumour and TMEM27 expression in all cases as well as in the cohort of patients with postoperative tumour progression. In multivariate analysis, only T stadium and TMEM27 staining showed a significant association with postoperative cancer-specific death (p < 0.001).

Conclusions

Lack of expression of the TMEM27 in conventional RCC defines a group of patients at high risk for cancer-related death.

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Title: Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma
Authors: Andras Javorhazy
Nelli Farkas
Tamas Beothe
Csaba Pusztai
Arpad Szanto
Gyula Kovacs
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 9/2016
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2207-3

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Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma

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Purpose

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Results

Conclusions

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