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Published in: Journal of Cancer Research and Clinical Oncology 12/2014

01-12-2014 | Rapid Communication

IMP3 expression in gastric cancer: association with clinicopathological features and HER2 status

Authors: Emanuel Adelino M. Damasceno, Fabiana Pirani Carneiro, Albino Verçosa de Magalhães, Marcos de Vasconcelos Carneiro, Gustavo Henrique Soares Takano, Leonora Maciel de Sousa Vianna, Heinrich Bender Kohnert Seidler, Tercia Maria Mendes Lousa de Castro, Maria Imaculada Muniz-Junqueira, Rivadávio Fernandes Batista Amorim, Vânia Maria Moraes Ferreira, Andrea Barreto Motoyama

Published in: Journal of Cancer Research and Clinical Oncology | Issue 12/2014

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Abstract

Background

The aim of this study was to evaluate the expression of IMP3, an independent poor prognostic factor for many cancers, and its association with clinicopathological features and HER2 status.

Methods

Gastrectomy specimens from 106 patients were evaluated by immunohistochemistry and fluorescence in situ hybridization.

Results

HER2 overexpression was found in 4.71 % of the samples. A negative association was observed between HER2 overexpression and grade of differentiation. No association was observed between HER2 overexpression and status of surgical margins, vascular invasion, perineural invasion, nodal metastasis and depth of invasion. Among all specimens of gastric cancer, 67.92 % were positive for IMP3. Expression of IMP3 was significantly higher in specimens with vascular invasion, perineural invasion, nodal metastasis and higher depth of invasion. HER2 overexpression was detected in only 5.55 % of IMP3 positive specimens.

Conclusions

IMP3 expression was frequently observed in gastric cancer and was associated with poor prognostic clinicopathological features. A survival benefit with HER2 therapy should be expected for the minority of patients with IMP3 positive specimens. Studies should be conducted to evaluate the response to HER2 therapy of gastric cancer expressing IMP3.
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Metadata
Title
IMP3 expression in gastric cancer: association with clinicopathological features and HER2 status
Authors
Emanuel Adelino M. Damasceno
Fabiana Pirani Carneiro
Albino Verçosa de Magalhães
Marcos de Vasconcelos Carneiro
Gustavo Henrique Soares Takano
Leonora Maciel de Sousa Vianna
Heinrich Bender Kohnert Seidler
Tercia Maria Mendes Lousa de Castro
Maria Imaculada Muniz-Junqueira
Rivadávio Fernandes Batista Amorim
Vânia Maria Moraes Ferreira
Andrea Barreto Motoyama
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 12/2014
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-014-1850-9

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