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Journal of Cancer Research and Clinical Oncology
Published in: Journal of Cancer Research and Clinical Oncology 3/2014

01-03-2014 | Original Paper

Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro

Authors: Zhou Shan, Guo Yang, Wang Xiang, Wang Pei-jun, Zhang Bin

Published in: Journal of Cancer Research and Clinical Oncology | Issue 3/2014

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Abstract

Purpose

Resveratrol has been reported to exhibit anti-cancer activity. The aim of this study was to examine the effects of resveratrol on the adhesion, migration, and invasion of the oral squamous cell carcinoma (OSCC) cell line KB cell in vitro.

Methods

The effect of resveratrol on KB cell adhesion was evaluated by a MTT colorimetric assay, whereas its effects on cell migration and invasion were assessed by a Transwell assay.

Results

The MTT assay revealed that the adhesion of KB cells treated with 100 μmol resveratrol for 1 or 2 h was decreased by 49.92 and 58.21 %, respectively (P < 0.05). In the Transwell assay, the migratory and invasive abilities of KB cells treated with 100 μmol resveratrol were decreased by 43.98 and 37.69 %, respectively.

Conclusions

Resveratrol inhibited the adhesion, migration, and invasion of OSCC cells in vitro, suggesting that it might serve as a chemopreventive agent for reducing the invasion and metastasis of OSCC.
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Metadata
Title
Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro
Authors
Zhou Shan
Guo Yang
Wang Xiang
Wang Pei-jun
Zhang Bin
Publication date
01-03-2014
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 3/2014
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-013-1575-1

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