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Journal of Cancer Research and Clinical Oncology

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01-02-2013 | Original Paper

Prognostic value of ERCC1 in head and neck carcinoma treated with definitive or adjuvant radiotherapy

Authors: Vesna Bišof, Antonija Jakovčević, Sven Seiwerth, Zoran Rakušić, Slavko Gašparov

Published in: Journal of Cancer Research and Clinical Oncology | Issue 2/2013

Abstract

Purpose

To evaluate the prognostic significance of excision repair cross-complementation group 1 (ERCC1) expression in head and neck carcinoma patients treated with definitive radiotherapy (DR) or adjuvant radiotherapy (AR).

Methods

ERCC1 expression was assessed by immunohistochemical staining. A total of 48 patients were assessed.

Results

High ERCC1 expression was found in 23 patients (48 %). More ERCC1-positive tumours were detected in patients treated with DR than in patients treated with AR (73 vs. 36 %, respectively, p = 0.03). ERCC1 expression had no impact on overall survival neither in the whole cohort of patients (p = 0.16) nor in each particular treatment group (AR p = 0.98; DR p = 0.21).

Conclusions

ERCC1 expression had no predictive value in head and neck carcinoma patients treated with DR or AR. There might be difference in ERCC1 positivity that comes out of whether the assessment is done on biopsy or surgical specimens.

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Title: Prognostic value of ERCC1 in head and neck carcinoma treated with definitive or adjuvant radiotherapy
Authors: Vesna Bišof
Antonija Jakovčević
Sven Seiwerth
Zoran Rakušić
Slavko Gašparov
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 2/2013
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-012-1318-8

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Prognostic value of ERCC1 in head and neck carcinoma treated with definitive or adjuvant radiotherapy

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Purpose

Methods

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Conclusions

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