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Journal of Cancer Research and Clinical Oncology

Published in:

01-04-2012 | Original Paper

Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion

Authors: Jinjin Yu, Yuan Wang, Ruofan Dong, Xiaoyan Huang, Suning Ding, Haifeng Qiu

Published in: Journal of Cancer Research and Clinical Oncology | Issue 4/2012

Abstract

Backgrounds

microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics.

Methods

The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software.

Results

In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.

Conclusions

microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.

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Title: Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion
Authors: Jinjin Yu
Yuan Wang
Ruofan Dong
Xiaoyan Huang
Suning Ding
Haifeng Qiu
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 4/2012
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-012-1147-9

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Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion

Abstract

Backgrounds

Methods

Results

Conclusions

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Abstract

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Methods

Results

Conclusions

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