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Journal of Cancer Research and Clinical Oncology

Published in:

01-12-2009 | Original Paper

Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer

Authors: Ming-Huang Chen, Peter Mu-Hsin Chang, Po-Min Chen, Cheng-Hwai Tzeng, Pen-Yuan Chu, Shyue-Yih Chang, Muh-Hwa Yang

Published in: Journal of Cancer Research and Clinical Oncology | Issue 12/2009

Abstract

Background

The purpose of this retrospective study was to test whether the pretreatment hematologic profile can predict the prognosis of patients with head and neck cancer.

Methods

Medical records from 278 patients with head and neck cancer were reviewed, and 270 cases were evaluable. Clinical data including age, gender, stage, pretreatment hematologic profile (including white blood cell, platelet, and differential counts, and hemoglobin level) were recorded. Statistical analyses were performed to determine the prognostic effect of these hematologic indicators, as well as clinical variables. The association between the hematologic indicators and clinical factors was also analyzed.

Results

Pretreatment monocytes >1,000 cells/μl (P = 0.028), hemoglobin <11.0 g/dl (P = 0.022), and platelet count >400 × 10³ cells/μl (P = 0.017) were identified as independent prognostic factors in addition to the nodal status and metastasis. A significant correlation between T-stage/monocyte or platelet count and metastasis/platelet count were shown. Monocytosis, anemia, and thrombocytosis were demonstrated to have a cumulative effect on the prognosis of head and neck cancer patients (normal vs. abnormality in one lineage, P = 0.001; abnormality in one vs. more than one lineage, P = 0.005).

Conclusions

A pretreatment hematologic profile can be considered as a useful prognostic marker in patients with head and neck cancer.

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Title: Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer
Authors: Ming-Huang Chen
Peter Mu-Hsin Chang
Po-Min Chen
Cheng-Hwai Tzeng
Pen-Yuan Chu
Shyue-Yih Chang
Muh-Hwa Yang
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 12/2009
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-009-0625-1

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