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Published in: Journal of Cancer Research and Clinical Oncology 9/2004

01-09-2004 | Original Paper

Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers

Authors: Masamitsu Onda, Mitsuru Emi, Hisaki Nagai, Takemitsu Nagahata, Kouji Tsumagari, Takashi Fujimoto, Futoshi Akiyama, Goi Sakamoto, Masujirou Makita, Fujio Kasumi, Yoshio Miki, Toshihiro Tanaka, Tatsuhiko Tsunoda, Yusuke Nakamura

Published in: Journal of Cancer Research and Clinical Oncology | Issue 9/2004

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Abstract

Purpose

To establish the novel prognostic markers for breast cancer, gene expression profile was examined genome-wide.

Methods

We used cDNA microarray consisting of 18,432 human genes to compare genome-wide expression profiles of eight primary breast cancers, four from patients who died of breast cancer within 5 years after surgery (5D group) and four who survived disease-free for more than 5 years (5S group).

Results

We identified 21 genes whose expression was greater in tumors from the 5D group than in 5S tumors, and 23 with higher expression in the 5S group than in the 5D group. We established a Prognostic Index (PI) for prediction of postoperative prognosis, based on the aberrant expression profiles of ten of those genes. Among 20 additional cases chosen blindly, ten presented with high prognostic scores (>7, good) according to the PI; the remaining ten cases revealed scores <7 (poor). The PI predicted the actual 5-year clinical outcomes of these 20 cases with 100% accuracy.

Conclusion

Our PI system is reliable in clinical settings for predicting postoperative risk for breast cancer. The extensive list of genes provides valuable information about progression of breast cancer and suggests potential target molecules for treating this disease.
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Metadata
Title
Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers
Authors
Masamitsu Onda
Mitsuru Emi
Hisaki Nagai
Takemitsu Nagahata
Kouji Tsumagari
Takashi Fujimoto
Futoshi Akiyama
Goi Sakamoto
Masujirou Makita
Fujio Kasumi
Yoshio Miki
Toshihiro Tanaka
Tatsuhiko Tsunoda
Yusuke Nakamura
Publication date
01-09-2004
Publisher
Springer-Verlag
Published in
Journal of Cancer Research and Clinical Oncology / Issue 9/2004
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-004-0574-7

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