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European Journal of Pediatrics
Published in: European Journal of Pediatrics 7/2019

Open Access 01-07-2019 | Attention Deficit Hyperactivity Disorder | Original Article

Rethinking ADHD intervention trials: feasibility testing of two treatments and a methodology

Authors: Philippa Fibert, Tessa Peasgood, Clare Relton

Published in: European Journal of Pediatrics | Issue 7/2019

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Abstract

Attention deficit hyperactivity disorder (ADHD) is a lifelong condition associated with considerable costs. The long-term effectiveness and acceptability of treatments to improve outcomes remains in doubt. Long-term trials are needed comparing interventions with standard care and each other. The Sheffield Treatments for ADHD Research (STAR) project used the Trials within Cohorts (TwiCs) approach. A cohort of children with ADHD was recruited and outcomes collected from carers and teachers. A random selection was offered treatment by homoeopaths (hom) or nutritional therapists (NT). Their outcomes (Conners Global ADHD Index) were compared with those not offered interventions. The feasibility of the methods and interventions was assessed. The TwiCs approach was feasible with modifications. 144 participants were recruited to the cohort, 83 offered treatment, 72 accepted, and 50 attended 1+ appointments. Results according to carers assessments at 6 months were as follows: t = 1.08, p = .28 (− 1.48, 4.81) SMD .425 (hom); t = 1.71, p = .09 (− .347, 5.89), SMD = .388 (NT). Teachers’ responses were too few and unstable. No serious treatment adverse events occurred.
Conclusion: the STAR project demonstrated the feasibility of the TwiCs approach for testing interventions for children with ADHD.
What is Known:
• Attention deficit hyperactivity disorder (ADHD) is a lifelong condition associated with considerable costs to ADHD stakeholders. Children are at risk of negative outcomes and in need of pre-emptive strategies
• The long-term effectiveness and acceptability of recommended treatments to improve outcomes remains in doubt
What is New:
• A small-scale test of the design demonstrated that the Trials within Cohorts (TwiCs) approach is feasible and can make a useful contribution regarding testing the effectiveness of interventions for children with ADHD to improve long-term negative outcomes
• Treatment by homoeopaths and nutritional therapists may offer novel opportunities to improve outcomes.
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Metadata
Title
Rethinking ADHD intervention trials: feasibility testing of two treatments and a methodology
Authors
Philippa Fibert
Tessa Peasgood
Clare Relton
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 7/2019
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-019-03374-z

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