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Open Access 01-04-2011 | Review

Aerosol delivery to ventilated newborn infants: historical challenges and new directions

Authors: Jan Mazela, Richard A. Polin

Published in: European Journal of Pediatrics | Issue 4/2011

Abstract

There are several aerosolized drugs which have been used in the treatment of neonatal respiratory illnesses, such as bronchodilators, diuretics, and surfactants. Preclinical in vitro and in vivo studies identified a number of variables that affect aerosol efficiency, including particle size, aerosol flows, nebulizer choice, and placement. Nevertheless, an optimized aerosol drug delivery system for mechanically ventilated infants still does not exist. Increasing interest in this form of drug delivery requires more controlled and focused research of drug/device combinations appropriate for the neonatal population. In the present article, we review the research that has been conducted thus far and discuss the next steps in developing the optimal aerosol delivery system for use in mechanically ventilated neonates.

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Title: Aerosol delivery to ventilated newborn infants: historical challenges and new directions
Authors: Jan Mazela
Richard A. Polin
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 4/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1292-6

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Aerosol delivery to ventilated newborn infants: historical challenges and new directions

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Keynote webinar | Spotlight on sleep in brain health

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