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01-08-2010 | Original Paper

Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis

Authors: Ioannis N. Mammas, George Sourvinos, Elena Vakonaki, Panagiota Giamarelou, Catherine Michael, Demetrios A. Spandidos

Published in: European Journal of Pediatrics | Issue 8/2010

Abstract

Introduction

Recurrent respiratory papillomatosis (RRP) is characterized by the presence of benign virally induced tumors of the larynx and respiratory epithelium that may obstruct the airway and tend to recur frequently. RRP is caused by the human papilloma virus (HPV), most frequently by HPV types 6 and 11. In this study, we present four cases of children with RRP in whom HPVs other than HPV-6 or HPV-11 were found.

Material and methods

In all four cases, HPV typing was performed by polymerase chain reaction (PCR) followed by restriction digestion (RFLP) in biopsy samples collected during surgery.

Results

In the first case, simultaneous HPV infection with types 13 and 39 was detected, while in the second case HPV-40 and HPV-56 were found. In cases 3 and 4, the biopsy samples were positive for unidentified ‘low-risk’ HPVs.

Conclusions

The presence of novel HPV genotypes in children with RRP emphasizes the need for further investigation of the implication of these genotypes in the disease.

Azzimonti B, Hertel L, Aluffi P, Pia F, Monga G, Zocchi M, Landolfo S, Gariglio M (1999) Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry. J Med Virol 59:110–116CrossRefPubMed

Barr E, Tamms G (2007) Quadrivalent human papillomavirus vaccine. Clin Infect Dis 45:609–617CrossRefPubMed

Bielecki I, Mniszek J, Cofała M (2009) Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children. Int J Pediatr Otorhinolaryngol 73:681–684CrossRefPubMed

Chesson HW, Forhan SE, Gottlieb SL, Markowitz LE (2008) The potential health and economic benefits of preventing recurrent respiratory papillomatosis through quadrivalent human papillomavirus vaccination. Vaccine 26:4513–4518CrossRefPubMed

Derkay C, Darrow D (2006) Recurrent respiratory papillomatosis. Ann Otol Rhino Laryngol 115:1–11

Gallagher TQ, Derkay CS (2009) Pharmacotherapy of recurrent respiratory papillomatosis: an expert opinion. Expert Opin Pharmacother 10:645–655CrossRefPubMed

Gerein V, Schmandt S, Babkina N, Barysik N, Coerdt W, Pfister H (2007) Human papilloma virus (HPV)-associated gynecological alteration in mothers of children with recurrent respiratory papillomatosis during long-term observation. Detect Prev Cancer 31:276–281CrossRef

Hartley C, Hamilton J, Birzgalis AR, Farrington WT (1994) Recurrent respiratory papillomatosis—the Manchester experience, 1974–1992. J Laryngol Otol 108:226–229PubMed

Hawkes M, Campisi P, Zafar R, Punthakee X, Dupuis A, Forte V, Ford-Jones EL (2008) Time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus. Pediatr Infect Dis J 27:149–154CrossRefPubMed

10.

Lin KY, Westra WH, Kashima HK, Mounts P, Wu TC (1997) Coinfection of HPV-11 and HPV-16 in a case of laryngeal squamous papillomas with severe dysplasia. Laryngoscope 107:942–947CrossRefPubMed

11.

Nicollas R, Henry M, Triglia JM, Tamalet C (2007) HPV type 6 and 16 co-infection in a 11-year-old girl presenting laryngeal papillomatosis. J Clin Virol 40:252–254CrossRefPubMed

12.

Maloney EM, Unger ER, Tucker RA, Swan D, Karem K, Todd NW, Reeves WC (2006) Longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 132:711–715CrossRefPubMed

13.

Mammas IN, Sourvinos G, Spandidos DA (2009) Human papilloma virus (HPV) infection in children and adolescents. Eur J Pediatr 168:267–273CrossRefPubMed

14.

McKaig RG, Baric RS, Olshan AF (1998) Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head Neck 20:250–265CrossRefPubMed

15.

Moore CE, Wiatrak BJ, McClatchey KD, Koopmann CF, Thomas GR, Bradford CR, Carey TE (1999) High-risk human papillomavirus types and squamous cell carcinoma in patients with respiratory papillomas. Otolaryngol Head Neck Surg 120:698–705CrossRefPubMed

16.

Morshed K, Polz-Dacewicz M, Szymański M, Polz D (2008) Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation. Eur Arch Otorhinolaryngol 265:S89–S96CrossRefPubMed

17.

Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, Snijders PJ, Meijer CJ, International Agency for Research on Cancer Multicenter Cervical Cancer Study Group (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518–527CrossRefPubMed

18.

Raffle AE (2007) Challenges of implementing human papillomavirus (HPV) vaccination policy. Br Med J 335:375–377CrossRef

19.

Rimell FL, Shoemaker DL, Pou AM, Jordan JA, Post JC, Ehrlich GD (1997) Pediatric respiratory papillomatosis: prognostic role of viral typing and cofactors. Laryngoscope 107:915–918CrossRefPubMed

20.

Shah K, Kashima H, Polk F et al (1986) Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis. Obstet Gynecol 68:795–799PubMed

21.

Sharma G, DeHart J, Nuovo GJ (2005) Correlation of histology, human papillomavirus, and viral load in laryngeal papillomas of childhood. Diagn Mol Pathology 14:230–236CrossRef

22.

Shehata B, Otto K, Sobol S, Stockwell C, Foulks C, Lancaster W, Gregoire L, Hill C (2007) E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP). Pediatr Dev Pathol 20:1

23.

Simon M, Kahn T, Schneider A, Pirsig W (1994) Laryngeal carcinoma in a 12-year-old child. Association with human papillomavirus 18 and 33. Arch Otolaryngol Head Neck Surg 120:277–282PubMed

24.

Tasca RA, Clarke RW (2006) Recurrent respiratory papillomatosis. Arch Dis Child 91:689–691CrossRefPubMed

25.

Torrente MC, Ampuero S, Abud M, Ojeda JM (2005) Molecular detection and typing of human papillomavirus in laryngeal carcinoma specimens. Acta Otolaryngol 125:888–893PubMed

26.

Wiatrak B (2003) Overview of recurrent respiratory papillomatosis. Curr Opin Otalaryngol Head Neck Surg 11:433–941CrossRef

27.

Wiatrak BJ, Wiatrak DW, Broker TR, Lewis L (2004) Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope 114:1–23CrossRefPubMed

28.

Zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2:342–350CrossRefPubMed

Title: Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis
Authors: Ioannis N. Mammas
George Sourvinos
Elena Vakonaki
Panagiota Giamarelou
Catherine Michael
Demetrios A. Spandidos
Publication date: 01-08-2010
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 8/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1174-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis

Abstract

Introduction

Material and methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Material and methods

Results

Conclusions

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