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European Journal of Pediatrics
Published in: European Journal of Pediatrics 12/2003

01-12-2003 | Original Paper

Malignant hypertension and cerebral haemorrhage in Seckel syndrome

Authors: Rossella Di Bartolomeo, Giancarlo Polidori, Marco Piastra, Luigi Viola, Guiseppe Zampino, Antonio Chiaretti

Published in: European Journal of Pediatrics | Issue 12/2003

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Abstract

Seckel syndrome is an autosomal recessive condition with severe short stature and facial and neurological anomalies. Intracranial haemorrhage, due to rupture of a cerebral aneurysm, is a very rare complication of this syndrome. Malignant hypertension may play an important role in the aetiology of the aneurysm and early detection is essential in order to prevent organ damage. Conclusion:we report a new case of Seckel syndrome associated with malignant hypertension and cerebral haemorrhage.
Literature
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Borglum AD, Balslev T, Haagerup A, Birkebaek N, Binderup H, Kruse TA, Hertz JM (2001) A new locus for Seckel syndrome on chromosome 18p 11.31-q11.2. Eur J Hum Gen 9: 753–757CrossRef
2.
D’Angelo V, Ceddia AMP, Zelante L, Florio FP (1998) Multiple intracranial aneurysms in a patient with Seckel syndrome. Childs Nerv Syst 14: 82–84CrossRefPubMed
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Faivre L, Le Merrer M, Lyonnet S, Plauchu H, Dagonneau N, Campos-Xavier AB, Attia-Sobol J, Verloes A, Munnich A, Cormier Daire V (2002) Clinical and genetic heterogeneity of Seckel syndrome. Am J Med Genet 112: 379–383CrossRefPubMed
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Goodship J, Gill H, Carter J, Jackson A, Splitt M, Wright M (2000) Autozygosity mapping of a Seckel syndrome locus to chromosome 3q22.1-q24. Am J Hum Genet 67: 498–503CrossRefPubMed
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National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents (1996) Update on the 1987 task force report on high pressure in children and adolescents: a working group from the national high blood pressure education program. Pediatrics 98: 649–658PubMed
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Sorof JM, Dow-Smith C, Moore PJ (1999) Severe hypertensive sequelae in a child with Seckel syndrome (bird-like dwarfism). Pediatr Nephrol 13: 343–346CrossRefPubMed
Metadata
Title
Malignant hypertension and cerebral haemorrhage in Seckel syndrome
Authors
Rossella Di Bartolomeo
Giancarlo Polidori
Marco Piastra
Luigi Viola
Guiseppe Zampino
Antonio Chiaretti
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 12/2003
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-003-1310-z

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